Pharmaceutical Research and

The number of known cytokines, as well as the diversity of biological functions, have led to a very complex and often confusing picture of the immunologic and nonimmunologic processes involved. The role of cytokiaes in local or systemic homeostatic mechanisms related to physiological functions may be utilized therapeutically for treatment of cancer and a variety of other diseases (2). Pharmaceutical research and development efforts surrounding lL-1 are typical examples of the cytokine inhibition approach to chronic inflammation research (2). 

Several national organizations serve the professional needs of U.S. pharmacists. These reflect the practice milieu of members, eg, independent community pharmacies, chain dmg stores, and hospitals. The American Pharmaceutical Association (APhA), founded in 1852, is composed of the Academy of Pharmaceutical Research and Science, Academy of Pharmaceutical Practice and Management, and the Academy of Students of Pharmacy. Other organizations include the American Society of Health-Systems Pharmacists (ASHP), National Association of Chain Dmg Stores (NACDS), and National Association of Retail Dmggists (NARD). 

Neiv DrugApprovals in 1994, Pharmaceutical Research and Manufacturers of America, Washington, D.C., 1995. 

Char-Chang Shieh, Murali Gopalakrishnan Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott, Park, IL, USA... 

Johnson and Johnson Pharmaceutical Research and Development, LLC, Welsh and McKean Roads, P.O. Box 776, spring House, PA 19477-0776. 

In the frame of a medicinal project at J J Pharmaceutical Research and Development aimed at designing new potent and selective glycogen synthase kinase-3/i (GSK-3/3) inhibitors, the C-3 derivatization of the 1-methyl-4-[l-alkyl-lff-indol-3-yl]-lff-pyrrole-2,5-dione scaffold was explored [31]. Microwave-assisted Stille reaction of 3-chloro-l-methyl-4-[l-alkyl-lff-indol-3-yl]-lH-pyrrole-2,5-diones with (2,4-dimethoxy-5-pyrimidinyl)(tributyl) stannane at 200 °C yielded in 6 min the desired 3,4-diaryl-lff-pyrrole-2,5-diones in moderate yields (Scheme 12). 

Today, computers are so ubiquitous in pharmaceutical research and development that it may be hard to imagine a time when there were no computers to assist the medicinal chemist or biologist. A quarter-century ago, the notion of a computer on the desk of every scientist and company manager was not even contemplated. Now, computers are absolutely essential for generating, managing, and transmitting information. The aim of this chapter is to give a... 

Computer Applications in Pharmaceutical Research and Development, Edited by Sean Ekins. ISBN 0-471-73779-8 Copyright 2006 John Wiley Sons, Inc. 

PHARMACEUTICAL RESEARCH AND DEVELOPMENT PRODUCTIVITY CAN SOFTWARE HELP ... 

In conclusion, it is likely that computational approaches for metabolism prediction will continue to be developed and integrated with other algorithms for pharmaceutical research and development, which may in turn ultimately aid in their more widespread use in both industry and academia. Such models may already be having some impact when integrated with bioanalytical approaches to narrow the search for possible metabolites that are experimentally observed. Software that can be updated by the user as new metabolism information becomes available would also be of further potential value. The held of metabolism prediction has therefore advanced rapidly over the past decade, and it will be important to maintain this momentum in the future as the hndings from crystal structures for many discrete metabolic enzymes are integrated with the diverse types of computational models already derived. 

---