In-depth search

Perestrelo, R., Barros, A. S., Camara, J. S., and Rocha, S. M. (2011). In-depth search focused on furans, lactones, volatile phenols, and acetals as potential age markers of Madeira wines by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry combined with solid phase microextraction. ]. Agric. Food Chem. 59, 3186-3204. 

Delphion (formerly IBM Intellectual Property database Ref. 8) allows for more in-depth search of patents and access to many consolidated databases. It is a low-cost solution. 

Figure 8.3 Strategies for in-depth search (a) and in-breadth search (b).

For systematic search in a knowledge base, two strategies are feasible first, in-depth searching and second, in-breadth searching (Figure 8.3). In the case of in-depth search, new states (facts, rules) are positioned on the top of the logical chain, that is, the latest retrieved states are eliminated first (last-in/first-out) if they do not satisfy. In contrast, in the in-breadth search, the additional states are linked to the end of the chain. The initially tested rules are eliminated first (first-in/first-out). 

This section reviews the evidence for IST s relationship with depression and suicidal droughts. The evidence examined included an in-depth search in databases. 

Figure 6-4. Backtracking approach realized as depth-first search aigorithm. Dotted arrows trace the route used for traversing all mappings in the search tree. Each node in the tree corresponds to a mapping between Cq and C-p (Figure 6-2).

Bioluminescence functions in mating (fireflies, the Bahama fireworm), in the search for prey (angler fish, Photmus fireflies), camouflage (hatchet fish, squid), schooling (euphausiid shrimp), and to aid deep water fish (flashlight fish, Photoblepharon to see in the dark ocean depths. 

To give a thorough, rational review of the field of chemical micro-process technology itself, one ideally would like to follow a deductive analysis route, pursuing a bottom-up approach. First, one may provide a definition of micro reactors, then search for the impacts on the engineering of chemical processes, and try to propose routes for exploitation, i.e. applications. Alternatively, for a less comprehensive, but more in-depth description, one could use a top-dovm approach starting with a selected application and try to design an ideal micro reactor for this. 

There are several examples in the literature of recent years of convincing numerical demonstrations that a compound not yet observed has a stable structure. It must be remarked that these studies usually regard compounds of marginal chemical interest, and that for innovative problems the quantum approach has always been late with respect to the experiments. This delay decreases, but it is unlikely to expect that the leadership in the search of new compounds will be assumed by in-depth calculations. 

Mineral exploration, the search for economic ore deposits, requires somewhat different reference samples than those used in ore valuation. Soil or sediment and water samples are frequently used in the search when mineralized areas of abundant outcrop or those covered only by thin locally derived overburden are being evaluated. In such cases, it is virtually impossible not to detect the mineralization from an analysis of ore elements in these types of samples. Later, as the mineral deposits closest to the surface were exploited and then played out, new deposits occurred at progressively greater depths, and these sample types were less and less effective as markers in the search (Hoffman 1989). 

This book is written in a straightforward easy-to-use style that is not exclusively technical. It has an in-depth examination of the Internet research process, and helps readers by offering different search techniques. Most importantly, it discusses how to evaluate and compare diverse web sources. It also offers online companion websites that complement its chapters. 

Integration of select Internet resources, such as the public chemical databases mentioned above, provides a very practical approach to structure searching the Internet and internal resources (Dong et al. 2007). Chapter 8 elaborates on this concept. As summarized in Chapter 2, another facet of chemical structure mining involves finding information within full text documents that do not traditionally contain identifiers like InChl or SMILE strings. Chapter 5 contains an in-depth discussion of these identifiers. 

Against all odds, the pharmaceutical industry began an intensive search for these magic bullets . Fortunately, production and crystallization of kinases is relatively easy in comparison to other protein families, and an impressive number of crystal structures of many kinases and their small-molecule inhibitors has become available (see Figure 7.16, Section 7.4.1). This wealth of structural information has aided the design and synthesis of high-affinity ligands for kinases. An in-depth discussion of these structures is included in Section 7.4. 

---