Mannane

Mannan Talukder Curtis R. Kates Advanced Aromatics, Inc. 

P-D-mannan with single 6-Unked a-D-galactose branches g 4)-p -D-glucomannan ... 

They encapsulated poly(MA-CDA) into mannan-coated liposomes and evaluated superoxide production from mouse macrophages. The activity was three- to five-fold high compared with uncapsulated poly(MA-CDA) itself [5,11], suggesting that an increased incorporation of the polymer by the receptor-mediated endocytosis mediated the higher biological activity.. 

Many different types of carbohydrate-containing molecules are located on the surface of microbial cells. Some of these are components of die microbial cell wall and are limited to certain types of micro-organisms such as bacterial peptidoglycan, lipopolysaccharides, techoic adds and yeast mannans. Other polysaccharides are not... 

Mannans (Tagut Nut, Corajo, Vegetable Ivory, Carobean), (CgHioOg, mw 162.14. Poly-, meric polysaccharides which yield mannose on hydrolysis. They can be acetylated and nitrated... 

Note. Examples of established usage of the -an ending are xylan for polymers of xylose, mannan for polymers of mannose, and galactan for polymers of galactose. Cellulose and starch are both glucans, as they are composed of glucose residues. 

Note. A less branched D-galacto-D-mannan could be shown in the short form as ... 

Fig. 6.—X-Ray diffraction pattern from mannan I (5), showing 2-fold helix symmetry and a orepeat of 10.27 A.

Fig, 7.—Antiparallel packing arrangement of the 2-fold helices of mannan I (5). (a) Stereo view of two unit cells approximately normal to the fee-plane. The two comer chains (open bonds) in the back are not hydrogen bonded to each other. The antiparallel center chain (filled bonds) is linked to the left comer chain by 2-OH 0-5 bonds, (b) Projection of the unit cell along the c-axis the a-axis is down the page. This highlights the hydrogen bonds between the comer and center chains. 

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