Mannan yeast, biosynthesis

Scheme 3.—Biosynthesis of the Core Oligosaccharide AT-Glycosylically Linked to L-Asparagine in Yeast Mannans.10 11 86 11 111-117-1 8-160-161...

Figure 6.5 The tentative coupling of PolyP and mannan biosynthesis in yeast Dol-PP, dolichyl diphosphate Dol-P, dolichyl phosphate GDPMan, GDPmannose Dol-PP-Man, dolichyl diphosphate mannose (Man) , mannan, where n is the number of mannose residues.

Figure 7.4 The putative pathway of coordination of mannan and PolyP biosynthesis in yeast.

Yu. A. Shabalin, V. M. Vagabov and I. S. Kulaev (1979). On the coupling mechanism of biosynthesis of high-molecular polyphosphates and mannan in Saccharomyces carlsbergensis yeast. Dokl. Akad. Nauk SSSR, 249, 243-246. 

Japanese Journal of Experimental Mediciney 37, 79-81 Tanner, W. (1969) A Lipid Intermediate in Mannan Biosynthesis in Yeast , Biochemical and Biophysical Research Communications, 35,144-150 Tanner, W., Babczinski, P., Marriott, M., Hasilik, A. Lehle, L. (1979) Glycosylation of Intra- and Extra-cellular Yeast Glycoproteins , Biochemical Society Transactions, 7, 329-31... 

The biosynthesis of the mannan inner core involves dolichol pyrophosphate derivatives containing JV-acetyl glucosamine and several mannose residues [38]. The participation of the polyprenol (dolichol) in the biosynthesis of the mannan inner core in yeast is analagous to its role in animal tissues as a mechanism for the glycosylation of proteins. 

Mannans.—The chemistry, structures, and biosynthesis of D-mannans in the cell-wall envelopes of yeasts have been reviewed. 

The initial studies carried out on the biosynthesis of yeast wall were directed towards learning the mechanisms of sugar polymerization in vivo, Bretthauer et fed Han-senula holstii cells with radioactive glucose or mannose and found that the extracellular mannan was produced from either sugar. 

Antalis, C., Fogel, S. and Ballou, C. E, (1973) Genetic control of yeast mannan structure. Mapping the first gene concerned with mannan biosynthesis. J. Biol. Chem. 248, 4655-4659. 

Sentandreu, R. and Lampen, J. O. (1970) Biosynthesis of yeast mannan Inhibition of synthesis of mannose acceptor by cycloheximide. FEBS Lett. 11, 95-99. 

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