Anti-oncogenes

Green, M.R. (1989). When the products of oncogenes and anti-oncogenes meet. Cell 56, 1-3. 

Nuclear tumor suppressors inhibit return to the cell cycle in fully differentiated cells. The genes that code for these proteins are referred to as anti-oncogenes due to this function. On the role of p53 and pRb, see p.394. 

Taken together, the various observations suggest that FBXLIO has context-dependent pro- and anti-oncogenic activities. In line with this, FBXLIO expression was reported to be significantly decreased in human glioblastomas relative to normal brain tissue [54], while FBXLIO was found to be overexpressed in lymphomas and mammary adenocarcinomas [56]. 

Linzer, D. I. H., The marriage of oncogenes and anti-oncogenes. Trends Genet. 4 245-247, 1988. 

Wei, H. 1992. Activation of oncogenes and/or inactivation of anti-oncogene by reactive oxygen species. Med. Hypotheses 39, 267-270. 

Mutations in the ras family of proto-oncogenes (comprising H-ray, N-roj and K-ras) are very common. The ras inhibitor, trans-farnesylthiosalicylic acid (FTS, sahrasib), exhibits profound anti-oncogenic effects in many cancer cell lines. 

Knudson AG Jr. Hereditary cancer, oncogenes, and anti-oncogenes. Cancer Res 1985 45 1437-81,... 

Horowitz, J.M., S.H. Par, E. Bogenmann, J.C. Cheng, D.W. Yandell, F.J. Kaye, T.P. Dryja and R.A. Weinberg. Frequent inactivation of retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc. Natl. Acad. Sci. USA 87 2775-2790, 1990. 

Terada T, Ohta T, Nakanuma Y. Expression of oncogene products, anti-oncogene products and oncofetal antigens in intraductal papillary-mucinous neoplasm of the pancreas. His-topathology. 1996 29 355-361. 

Consequence of RER phenotype Activation of anti-oncogenes Inactivation of antioncogenes... 

Whyte, P., Buchkovich, K.J., Horowitz, J.M., Friend, S.H., Raybuck, M., Weinberg, R.A. and Harlow, E. (1988) Association between an oncogene and an anti-oncogene the adenovirus El A proteins bind to the retinoblastoma gene product. Nature 334 124-129. 

Kerbel RS, Viloria-Petit A, Klement G, Rak J. Accidental anti-angiogenic drugs. Anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples. Eur J Cancer 2000 36 1248-1257. 

Menendez, J. A. Lupu, R. (2006). Mediterranean dietary traditions for the molecular treatment of human cancer anti-oncogenic actions of the main olive oil s monounsaturated fatty acid oleic acid (18 ln-9). Current Pharmaceutical Biotechnology, 7(6), 495-502. 

Kripke ML (1994) Ultraviolet radiation and immunology something new under the sun. Cancer Res 54 6102-6105 Lane DP, Benchimol S (1990) p53 oncogene or anti-oncogene. Genes Dev 4 1-8... 

Chemoprevention The act of NO release induces chemopreventive, cytoprotec-tive, and anti-oncogenic mechanisms in normal cells or inhibits cancer promotion and malignant transformation, or is anti-proliferative toward pre-cancerous cells. 

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