Major histocompatibility complex presentation

Brack AR, Klupp BG, Granzow H, Tirabassi R, Enquist LW, Mettenleiter TC (2000) Role of the cytoplasmic tail of pseudorabies virus glycoprotein E in virion formation. J Virol 74 4004-4016 Chen MM, Shirai M, Liu Z, Arichi T, Takahashi H, Hishioka M (1998) Efficient class II major histocompatibility complex presentation of endogenously synthesized hepatitis C virus core protein by Epstein-Barr virus-transformed B-lymphoblastoid cell lines to CD4( + ) T cells. J Virol 72 8301-8308... 

Furman MH, Ploegh HL, Schust DJ (2000) Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface Hum Immunol 61 1169-1176 Gilbert MJ, Riddell SR, Li CR, Greenberg PD (1993) Selective interference with class I major histocompatibility complex presentation of the major immediate-early protein following infection with human cytomegalovirus. J Virol 67 3461-3469... 

Autoimmune Disease. Figure 2 Generation of autoreactivity. APC, antigen presenting cell IFN, interferon LPS, lipopolysaccharide MHC, major histocompatibility complex T, T-lymphocyte TCR, Tcell (antigen) receptor TLR, toll like receptors. For details see text. 

The human leucocyte antigen (HLA) system is the general name of a group of genes in the human major histocompatibility complex (MHC) region on human chromosome 6 (mouse chromosome 17) that encodes the cell-surface antigen-presenting proteins. 

Group of transmembrane proteins engaged in the presentation of small peptide fragments to T-cells. Two classes of Major histocompatibility complex (MHC) molecules exist both of which are encoded by a highly polymorphic gene cluster. MHC class I and class II proteins present peptide fragments to CD8+ and CD4+ T-cells, respectively. The human MHC is also known as HLA, the murine MHC as H-2 complex. 

York lA, Goldberg AL, Mo XY, Rock KL Proteolysis 73 and class I major histocompatibility complex antigen presentation. Immunol Rev 1999 172 49-66. 

An unknown antigen presented by the major histocompatibility complex (MHC) class II molecules causes T cells to become autoreactive (Fig. 26-1). Once activated, T cells penetrate the... 

Family history of RA. Genetic studies demonstrate a strong correlation between RA and the presence of major histocompatibility complex class II human leukocyte antigens (HLA), specifically HLA-DR1 and HLA-DR4.4,5 HLA is a molecule associated with the presentation of antigens to T lymphocytes. 

Human leukocyte antigens (HLA) Groups of genes found on the major histocompatibility complex, which contain cell-surface antigen-presenting proteins. The body uses HLA to distinguish between self-cells and non-self-cells. 

The T-lymphocyte receptor (TCR) is involved in detection of foreign antigens, presented together with the major histocompatibility complex (MHC). Subsequendy, it regulates the clonal expansion of T cells. 

Immunoglobulins (Igs) can activate the complement system, which amplifies the immune response by enhancing chemotaxis, phagocytosis, and release of lymphokines by mononuclear cells that are then presented to T lymphocytes. The processed antigen is recognized by the major histocompatibility complex proteins on the lymphocyte surface, resulting in activation of T and B cells. 

The Major Histocompatibility Complex. The molecules making up the major histocompatibility complex (MHC) were first discovered through their ability to provoke rejection response when tissues from one individual were transplanted to another individual of the same species. Quite apart from the MHC s contribution to the difficulties of transplant surgery, in recent years it has become abundantly clear that the MHC plays a major role in the operation of T cell immunity, particularly in its function of presenting antigen to the T cell receptor. 

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