Major histocompatibility complex proteins

Tsomides, T.J., Walker, B.D., and Eisen, H.N. (1991) An optimal viral peptide recognized by CD8+T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein. Proc. Natl. Acad. Sci. USA 88, 11276-11280. 

Immunoglobulins (Igs) can activate the complement system, which amplifies the immune response by enhancing chemotaxis, phagocytosis, and release of lymphokines by mononuclear cells that are then presented to T lymphocytes. The processed antigen is recognized by the major histocompatibility complex proteins on the lymphocyte surface, resulting in activation of T and B cells. 

T. H. Watts, H. E. Gaub, and H. M. McConnell, T-cell-mediated association of peptide antigen and major histocompatibility complex protein detected by energy transfer in an evanescent wave-field, Nature 320, 176-179 (1986). 

They recognise small peptide antigens that mnst be bound to a specific protein, the major histocompatibility complex protein (MHC) (see below). 

Eisen, H.N., Sykulev, Y., Tsomides, T.J. (1996). Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex proteins. Adv. Prot. Chem. 49,1-56. 

Major-Histocompatibility-Complex Proteins Present Peptide Antigens on Cell Surfaces for Recognition by T-Cell Receptors... 

Major-Histocompatibility-Complex Proteins Present Peptide Antigens on Cell Surfaces for Recognition by T-Cell Receptors Intracellular pathogens such as viruses and mycobacteria cannot be easily detected. Intracellular proteins are constantly being cut into... 

Major-Histocompatibility-Complex Proteins Present Peptide Antigens... 

MAJOR-HISTOCOMPATIBILITY-COMPLEX PROTEINS PRESENT PEPTIDE ANTIGENS ON CELL SURFACES FOR RECOGNITION BY T-CELL RECEPTORS... 

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