Human Leucocyte Antigens

The human leucocyte antigen (HLA) system is the general name of a group of genes in the human major histocompatibility complex (MHC) region on human chromosome 6 (mouse chromosome 17) that encodes the cell-surface antigen-presenting proteins. 

Genes encoding particular class II Human Leucocyte Antigens (HLA) are among candidates for involvement in predisposition to RA. This discovery came about with the observation that 60- 70% of Caucasian patients with RA are HLA-DR4 positive by... 

Boyton R-J, Altmann DM Natural killer cells, killer immunoglobulin-like receptors and human leucocyte antigen class 1 in disease. Clin Exp Immunol 2007 149 1-8. 

Lee, S.T., Jang, J. H., Cheong, J. W., et al. (2002),Treatment of high-risk acute myelogenous leukaemia by myeloablative chemoradiotherapy followed by co-infusion of T cell-depleted haematopoietic stem cells and culture-expanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leucocyte antigen haplotype, Br. J. Haematol, 118(4), 1128-1131. 

Suzuki, K., Inoue, R., Sakaguchi, H., Aoki, M., Kato, Z., Kaneko, H. et al. 2002. The correlation between ovomucoid-derived peptides, human leucocyte antigen class II molecules and T cell receptor-complementarity determining region 3 compositions in patients with egg-white allergy. Clin Exp Allergy 32(8) 1223-1230. 

Flesch BK, Neppert J. Transfusion-related acute lung injury caused by human leucocyte antigen class II antibody. Br J Haematol 2002 II6(3) 673-6. 

The discussion in this chapter focussed at developments in the field of protein characterization, and provided an overview of the technology developed to enable proteomics studies (Ch. 18). The strategies outline above have been applied to increasingly complex samples. Some examples are the detection and identification of human leucocyte antigen peptides related to the major histocompatibility complex [166], and the unattended identification of 90 proteins from the yeast Saccharomyces cerevisiae by means of an integrated workstation for LC-MS-MS under DDA and with database searching [34]. 

The group of Hunt [1] pioneered the identification of trace-level peptides in complex biological samples by means of microcapillary reversed-phase RPLC-MS-MS in the analysis of endogenous human class I major histocompatibility complex (MHC) encoded human leucocyte antigen (HLA-A2.1) peptides. 

HLA human leucocyte antigens. hnRNA heterogenous nuclear RNA. 

Human leucocyte antigen, see HLA Human liver microsomes 1618 Human lysozyme... 

Note HIV/AIDS Human immunodeficiency virus/acquired immunodeficiency syndrome HLA Human leucocyte antigens CTL CytotoxicT-lymphocytes. 

Cell-surface molecules belonging to the Major Histocompatibility Complex (MHC) are responsible for the identification of self/non-self-antigens by the T cell receptors. In humans the MHC is referred to as HLA (Human Leucocyte Antigen) and its allelic expression... 

Several risk factors for the development of OB/BOS have been identified, that can be subdivided into immunological and nonimmunological risk factors. Late or recurrent/refractory acute rejection and lymphocytic bronchitis/bronchiolitis were the most convincing (16), which together with repeated Ai acute rejection, noncompliance, human leucocyte antigen (HLA) mismatches at the A locus and total HLA mismatches, constitute the immunological risk factors (17). 

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