Human major histocompatability complex

The human leucocyte antigen (HLA) system is the general name of a group of genes in the human major histocompatibility complex (MHC) region on human chromosome 6 (mouse chromosome 17) that encodes the cell-surface antigen-presenting proteins. 

Sargent, C.A., Dunhan, 1., Trowsdale, J., Campbell, R.D. (1989). Human major histocompatibility complex contains genes for the major heat shock protein hsp70. Proc. Natl. Acad. Sci. USA 86, 1968-1972. 

Song, Z., et al., A novel cysteine-ridi sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex dass II genes via a repeated Cys-His domain and functions as a transcriptional repressor. / Exp Med, 1994, 180(5), 1763-74. 

MHC Sequencing Consortium. 1999. complete sequence and gene map of a human major histocompatibility complex. Nature. 401 921-923. 

Groh, V., Bahram, S., Bauer, S., Herman, A., Beauchamp, M., and Spies, T. (1996). Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. USA 93, 12445-12450. 

The role of the immune system in the pathophysiology of Graves disease is well established. A considerable amount of information links the human major histocompatibility complex (human leukocyte antigen [HLA]) with Graves disease. For instance, several HLA types, such as HLA-B8 and HLA-DR3, are associated with this disorder. Graves disease in the Japanese has been found to be associated with HLA-B35, whereas in patients of Chinese... 

Bavari S, Ulrich RG Staphylococcal enterotoxin A and toxic shock syndrome toxin compete with CD4 for human major histocompatibility complex class II binding. Infect Immun 1995 63 423 429. 

U2, Uchiyama, T., Saito, S., Inoko, H., Yan, X, J., Imanishi, K., Araake, M., and Igarashi, H. Relative activities of distinct isotypes of murine and human major histocompatibility complex class 11 molecules in binding toxic shock syndrome toxin 1 and determination of CD antigens expressed on T cells generated upon stimulation by the toxin. Infect. Immun. 58, 3877-3882 (1990). 

II region of the human major histocompatibility complex by pulsed-field gel electrophoresis. Nature (London) 323, 453 55 (1986). 

Spies, T., Blanck, G., Bresnahan, M., Sands, J., and Strominger, J. L. A new cluster of genes within the human major histocompatibility complex. Science 243, 214-217 (1989). 

Tenzen T., Yamagata T., Fukagawa T., Sugaya K., Ando A., Inoko H., Gojobori T., Fujiyama A., Okumura K., Ikemura T. (1997). Precise switching of DNA replication timing in the GC content transition area in the human major histocompatibility complex. Mol. Cell Biol. 17 4043-4050. 

Braud V, Jones EY, McMichael A (1997) The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9. Eur J Immunol 27 1164-1169... 

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