Receptors lymphocytes

Lymphocyte response and effector function has recently been reviewed with respect to lymphocyte receptors, lymphocyte activation, T cell effector functions and lymphocyte physiology. The role of cell surface... 

The T-lymphocyte receptor (TCR) is involved in detection of foreign antigens, presented together with the major histocompatibility complex (MHC). Subsequendy, it regulates the clonal expansion of T cells. 

The B lymphocyte receptor for antigen is important in the first line of defense against infection by microorganisms. 

Lee, W.T., and Conrad, D.H. (1985) The murine lymphocyte receptor for IgE. III. Use of chemical cross-linking reagents to further characterize the B lymphocyte Fee receptor. J. Immunol. 134, 518-525. 

Pancer, Z., et al., Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey, Nature, 430, 174, 2004. 

Major characteristics Most abundant internal Ig Protects external surfaces Very efficient against bacteremia Mainly lymphocyte receptor Initiates inflammation, raised in parasitic infections, causes allergy symptoms... 

There is also considered to be a population of T suppressor cells which acts to down-regulate both T helper cells and B cells, whether through antigen-specific or idiotype-specific mechanisms. The epitopes on the lymphocyte receptor (id-iotype) recognized by the receptor on another lymphocyte (anti-idotype) can form a network of interactions through which suppression may be mediated. 

Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR (1998) Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell 95 625-636... 

Late antibodies Mucosa-protecting antibodies Early antibodies B-lymphocyte receptors Reagins... 

Following the administration of a 0.25-mg dose of DEX, it was possible to observe that the cortisol response was accompanied by a concurrent decline in the number of cytosolic lymphocyte receptors (Yehuda et al. 1995a). This finding contrasted with the observation of a reduced decline in the number of cytosolic lymphocyte receptors in major depression, implying that the reduced cortisol levels following DEX administration may reflect an enhanced negative feedback inhibition in PTSD (Gormley et al. 1985). 

Figure 31-16 Schematic depiction of lymphocyte receptors forming anti-idiotype and internal image sets as proposed by Jerne.

It is now possible to identify T-cell epitopes, which are recognized by receptor complexes on the T-lymphocyte surface, in addition to the B-cell epitopes recognized by antibodies (which are also the B-lymphocyte receptors). T-cells are stimulated by small peptide fragments of antigens produced by intracellular proteolytic processing, so problems of conformation do not arise, and syn-... 

LCA/leukocyte common antigen tyrosine phosphatase that reinforces T and B lymphocyte receptor signaling... 

Incorporation of cytokine in a naive Th lymphocyte receptor activates the route of Janus kinases (JAK1, JAK2, JAK3), transmission proteins for intracellular signals, and activating transcriptions—Signal Transducer and Activator Transcription (STAT)—consequently phosphorylation of receptor tyrosine results. 

T lymphocyte migration serves to bring the entire range of T lymphocyte receptor specificities in contact with antigen. It also serves to disseminate the products of an immune response, effector cells and memory cells, to... 

Clark CG, Armstrong GD (1990) Lymphocyte receptors for pertussis toxin. In Infect... 

Lymphocytes Receptor-mediated cell activation Melamed et al., 1991... 

Fig. 8.8 The process of MHC presentation of peptide and interaction with T-lymphocyte receptor (TCR). CytotoxicT lymphocytes (CD 8+) interact with MHC I (a), while helper T lymphocytes (CD4+) interact with MHC 11(b).

Smooth Muscle Contraction Platelet Aggregation Endothelial Cell Retraction Exocytosis (Neurotransmitters) Lymphocyte Receptor Capping Cell Migration... 

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