Major histocompatibility complex antigen presentation

York lA, Goldberg AL, Mo XY, Rock KL Proteolysis 73 and class I major histocompatibility complex antigen presentation. Immunol Rev 1999 172 49-66. 

Major-Histocompatibility-Complex Proteins Present Peptide Antigens on Cell Surfaces for Recognition by T-Cell Receptors... 

Major-Histocompatibility-Complex Proteins Present Peptide Antigens on Cell Surfaces for Recognition by T-Cell Receptors Intracellular pathogens such as viruses and mycobacteria cannot be easily detected. Intracellular proteins are constantly being cut into... 

Major-Histocompatibility-Complex Proteins Present Peptide Antigens... 

MAJOR-HISTOCOMPATIBILITY-COMPLEX PROTEINS PRESENT PEPTIDE ANTIGENS ON CELL SURFACES FOR RECOGNITION BY T-CELL RECEPTORS... 

Khanna R, Busson P, Burrows SR, Raffoux C, Moss DJ, Nicholls JM, Cooper L (1998) Molecular characterization of antigen-processing function in nasopharyngeal carcinoma (NPC) evidence for efficient presentation of Epstein-Barr virus cytotoxic T-cell epitopes by NPC cells. Cancer Res 58 31(>-314 King NJ, Maxwell LE, Kesson AM (1989) Induction of class I major histocompatibility complex antigen expression by West Nile virus on y interferon-refractory early murine trophoblast cells. Proc Natl Acad Sci USA 86 911-915... 

Autoimmune Disease. Figure 2 Generation of autoreactivity. APC, antigen presenting cell IFN, interferon LPS, lipopolysaccharide MHC, major histocompatibility complex T, T-lymphocyte TCR, Tcell (antigen) receptor TLR, toll like receptors. For details see text. 

The human leucocyte antigen (HLA) system is the general name of a group of genes in the human major histocompatibility complex (MHC) region on human chromosome 6 (mouse chromosome 17) that encodes the cell-surface antigen-presenting proteins. 

An unknown antigen presented by the major histocompatibility complex (MHC) class II molecules causes T cells to become autoreactive (Fig. 26-1). Once activated, T cells penetrate the... 

Family history of RA. Genetic studies demonstrate a strong correlation between RA and the presence of major histocompatibility complex class II human leukocyte antigens (HLA), specifically HLA-DR1 and HLA-DR4.4,5 HLA is a molecule associated with the presentation of antigens to T lymphocytes. 

Human leukocyte antigens (HLA) Groups of genes found on the major histocompatibility complex, which contain cell-surface antigen-presenting proteins. The body uses HLA to distinguish between self-cells and non-self-cells. 

The T-lymphocyte receptor (TCR) is involved in detection of foreign antigens, presented together with the major histocompatibility complex (MHC). Subsequendy, it regulates the clonal expansion of T cells. 

Immunoglobulins (Igs) can activate the complement system, which amplifies the immune response by enhancing chemotaxis, phagocytosis, and release of lymphokines by mononuclear cells that are then presented to T lymphocytes. The processed antigen is recognized by the major histocompatibility complex proteins on the lymphocyte surface, resulting in activation of T and B cells. 

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