Major histocompatibility complex class I molecules

Katz, J., Benoist, C. and Mathis, D. (1993). Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur. J. Immunol. 23, 3358-3360. 

Heeft, E.v.d. Hove, G.J.t. Herberts, C.A. Meiring, H.D. Els, C.A.C.M.v. Jong, A.P.J.M.d. A Microcapillary Column Switching HPLC-Electrospray Ionization MS System for the Direct Identification of Peptides Presented by Major Histocompatibility Complex Class I Molecules, Anal. Chem. 70, 3742-3751 (1998). 

Moore, S. E. H. Spiro, R. G. (1993). Inhibition of glucose trimming by castanospermine results in rapid degradation of unassembled major histocompatibility complex class I molecules. J. Biol. Chem. 268, 3809-3812. 

J Niedermann G, Butz S, Ihlenfeldt H-G, Grimm R, Lucchiari M, Hoschiilzky H, Jung G. Maier B, Eichmann K (1995) Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by the major histocompatibility complex class I molecules. Immunity 2 289-299. 

Olsen A, Wick MJ, Morgelin M, Bjorck L (1998) Curfi, fibrous surface proteins of Escherichia coli, interact with major histocompatibility complex class I molecules. Infect Immun 66 944-949... 

Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Celia M, Lopez-Botet M (1997) A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 186 1809-1818 Colonna M, Navarro F, Lopez-Botet M (1999) A novel family of inhibitory receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells. Curr Top Microbiol Immunol 244 115-122... 

Ishido S, Wang C, Lee BS, Cohen GB, Jung JU (2000b) Downregulation of major histocompatibility complex class I molecules by Kaposi s sarcoma-as.sociated herpesvirus K3 and K5 proteins [In Process Citation]. J Virol 74 5300--5309... 

Sester M, Burgert H-G (1994) Conserved cysteine residues within the E3/19K protein of adenovirus type 2 are essential for binding to major histocompatibility complex antigens. J Virol 68 5423-5432 Sester M, Feuerbach D, Frank R, Preckel T, Gutermann A, Burgert H-G (2000) The amyloid precursorlike protein 2 associates with the major histocompatibility complex class i molecule K. J Biol Chem... 

Degen, E., Cohen-Doyle, M.F., and Williams, D.B. Efficient Dissociation of the p88 Chaperone from Major Histocompatibility Complex Class I Molecules Requires Both P2-Microglobulin and Peptide J. Exp. Med. 1992 175, 1653 -1661. 

Moore, S.E.H. and Spiro, R.H. Inhibition of Glucose Trimming by Castanospermine Results in Rapid Degradation of Unassembled Major Histocompatibility Complex Class I Molecules. J. Biol Chem. 1993 268, 3809-3812. 

Bradley, J.R., Johnson, D.R. and Fober, J.S. (1993). Endothelial activation by hydre en peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I. Am. J. Pathol. 142, 1598-1609. 

The staphylococcal superantigens initially bind to conserved elements on major histocompatibility complex class II molecules with relatively high affinity (A(i 10 mol 1 ). These receptors are found in abundance, throughout the body, on antigen-presenting cells such as macrophages and monocytes. However, each toxin... 

Therapeutic monoclonal antibodies are widely recognized to be a most promising means to treat an increasing number of human diseases, including cancers and autoimmunity. To a large extent, the efficacy of monoclonal antibody treatment is because IgG antibodies have greatly extended persistence in vivo. However, conventional rodent models do not mirror human antibody pharmacokinetics. The key molecule responsible for the extended persistence antibodies is the major histocompatibility complex class I family Fc receptor, FcRn. We describe human FcRn transgenic mouse models and how they can be exploited productively for the preclinical pharmacokinetic evaluation of therapeutic antibodies. 

Mehindate K, Thibodeau I, Dohlsten M, Kalland T, Sekaly RP, Mourad W Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expression. J Exp Med 1995 182 1573-1577. 

Group of transmembrane proteins engaged in the presentation of small peptide fragments to T-cells. Two classes of Major histocompatibility complex (MHC) molecules exist both of which are encoded by a highly polymorphic gene cluster. MHC class I and class II proteins present peptide fragments to CD8+ and CD4+ T-cells, respectively. The human MHC is also known as HLA, the murine MHC as H-2 complex. 

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