Class I histocompatibility

Mr 11,800) globular protein located on the surface of virtually all nucleated cells. It is closely related to the class I histocompatibility antigens which consist of a heavy, variable chain and a hght chain that hinds to the heavy chain domain nearest to the cell membrane. The light chain consists of the molecule. Due to its... 

Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC Structure of the human class I histocompatibility antigen, HLA-A2. Nature 1987 329 506-512. 

Degen, E., and Williams, D. B. (1991). Participation of a novel 88-kDa protein in the biogenesis of murine class I histocompatibility molecules. J. Cell Biol. 112, 1099-1115. 

B14. Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., and Wiley, D. C. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature (London) 329, 512-518 (1987). 

There are several examples of parts of membrane proteins determined crystallographically. Here, a protein anchored in the membrane is clipped to provide just the hydrophilic domain for crystallisation. These studies were of cytochrome b5 (Mathews, Argos and Levine 1972), haemagglutinin (Wilson etal 1981) and neuraminidase (Varghese, Laver and Colman 1983) from influenza virus and the human class I histocompatibility antigen, HLA-A2 (Bjorkman et al 1987). 

Vassilakos, A., Cohen-Doyle, M.F., Peterson, P.A., Jackson, M.R., and Williams, D.B. The Molecular Chaperone Calnexin Facilitates Folding and Assembly of Class I Histocompatibility molecules EMBO J. 1996 15, 1495 1506. 

Group of transmembrane proteins engaged in the presentation of small peptide fragments to T-cells. Two classes of Major histocompatibility complex (MHC) molecules exist both of which are encoded by a highly polymorphic gene cluster. MHC class I and class II proteins present peptide fragments to CD8+ and CD4+ T-cells, respectively. The human MHC is also known as HLA, the murine MHC as H-2 complex. 

York lA, Goldberg AL, Mo XY, Rock KL Proteolysis 73 and class I major histocompatibility complex antigen presentation. Immunol Rev 1999 172 49-66. 

Bradley, J.R., Johnson, D.R. and Fober, J.S. (1993). Endothelial activation by hydre en peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I. Am. J. Pathol. 142, 1598-1609. 

Santos, S.G., Campbell, E.C., Lynch, S., Wong, V., Antoniou, A.N., and Powis, S.J. (2007) Major histocompatibility complex class I-ERp57-tapasin interactions within the peptide-loading complex. /. Biol. Cbem. 282(24), 17587-17593. 

Tsomides, T.J., Walker, B.D., and Eisen, H.N. (1991) An optimal viral peptide recognized by CD8+T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein. Proc. Natl. Acad. Sci. USA 88, 11276-11280. 

Paulsson, K. (2004) Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery. Cell. Mol. Life Sci. 61, 2446-2460. 

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