Obesity and diabetes

Lipidomics smdy has been broadly applied to explore the metabolic origin of diabetes and obesity eomplieations. For example, lipidomic analysis of lipid extracts from white adipose tissue in young healthy monozygous twins with different body weights was performed [20]. The study led to a finding that obese co-twins compared to 

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Marchal-Victorion, S., Vionnet, N., Escrieut, C., et al. (2002) Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients. Pharmacogenetics. 12, 23-30. 

Effect of Bile-Acid Sequestrants on Type-2 Diabetes and Obesity... 

In addition to the protective effects of BAS on atherosclerotic plaques and coronary artery disease, a recent study has suggested that BAS could have utility in the management of type-2 diabetes and obesity. 

Wolfson W. (2007) Leapin lizards Amylin targets diabetes and obesity via incretins. Chem Biol 14 235-236. 

Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, IQin.JAMA 2003 289 76-9. 

Coronary heart disease is one of the leading causes of death in the industrialized world (Packer, 1992 Remme and Swedberg, 2001). Hypertension is a risk factor for cardiovascular disease and is associated with an increased incidence of stroke and coronary heart disease. Other risk factors for cardiovascular disease include also high cholesterol, diabetes, and obesity. Although there have been many advances in treatment over the past several decades, less than a quarter of all hypertensive patients have their blood pressure adequately controlled with available therapies. 

It is indicated in arteriosclerosis, as adjunct in treatment of hypertension, diabetes and obesity. 

Type II diabetes is slow to develop (typically in older, obese individuals), and the symptoms are milder and often go unrecognized at first. This is really a group of diseases in which the regulatory activity of insulin is defective insulin is produced, but some feature of the insulin-response system is defective. These individuals are insulin-resistant. The connection between type II diabetes and obesity (discussed below) is an active area of research. 

Evidence from epidemiological studies demonstrates that exposures during early life stages can impact susceptibility to diabetes and obesity later in life (Lau Rogers, 2005). In particular, numerous studies have linked poor maternal nutrition with later risk for these adverse health outcomes. The Dutch Hunger Winter was a... 

HPI has compounds in clinical trials for a couple of therapy areas namely, phase II trials for cancer adjunct therapy, type II diabetes and obesity and phase I trials for acute pain. These are all significant therapeutic areas and clinical success in any of them would be a highly significant contribution to human health. 

Today, a moderate quantity of Jerusalem artichoke is recommended in diets aimed at countering diabetes and obesity. Eating Jerusalem artichoke daily, however, could become monotonous. Fortunately, foods incorporating tuber extracts also provide the health benefits of Jerusalem artichoke. Flour from Jerusalem artichoke, for instance, replaces wheat flour in a range of food products aimed at the weight-loss, health food, and diabetic food markets (Roberfroid and Delzenne, 1998). Jerusalem artichoke is also being added to butter, puree, drinks, and other products aimed at diabetics. 

By controlling the formation of phosphate esters on key proteins, the body is able to regulate many cellular processes. Any disruption of these phosphorylation processes can result in numerous health problems, including cancer, diabetes, and obesity. 

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