Major histocompatibility molecules

Donnelly JJ, Ulmer JB, Hawe JA, Friedman A, Shi XP, Leander KR, Shiver JW, Oliff Al, Martinez D, Montgomery D (1993) Targeted delivery of peptide epitopes to class I major histocompatibility molecules by a modified Pseudomonas exotoxin. Proc. Natl. Acad. Sci. USA 90 3530-3534. 

Roof RW, Luescher IF, Unanue ER. Phospholipids enhance the binding of peptides to class II major histocompatibility molecules. Proc Natl Acad Sci USA 1990 87 1735-1739. 

Kim J, Urban RG, Strominger JL, Wiley DC Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1. Science 1994 266 1870-1874. 

Group of transmembrane proteins engaged in the presentation of small peptide fragments to T-cells. Two classes of Major histocompatibility complex (MHC) molecules exist both of which are encoded by a highly polymorphic gene cluster. MHC class I and class II proteins present peptide fragments to CD8+ and CD4+ T-cells, respectively. The human MHC is also known as HLA, the murine MHC as H-2 complex. 

Aguas, A., Esaguy, N., Sunkel, C.E., Silva, M.T. (1990). Cross-reactivity and sequence homology between the 65 kilodalton mycobacterial heat shock protein and human lactoferrin, transferrin, and DR beta subsets of major histocompatibility complex class II molecules. Infect. Immun. 58, 1461-1470. 

The number of different proteins in a membrane varies from less than a dozen in the sarcoplasmic reticulum to over 100 in the plasma membrane. Most membrane proteins can be separated from one another using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), a technique that has revolutionized their study. In the absence of SDS, few membrane proteins would remain soluble during electrophoresis. Proteins are the major functional molecules of membranes and consist of enzymes, pumps and channels, structural components, antigens (eg, for histocompatibility), and receptors for various molecules. Because every membrane possesses a different complement of proteins, there is no such thing as a typical membrane structure. The enzymatic properties of several different membranes are shown in Table 41-2. 

Bradley, J.R., Johnson, D.R. and Fober, J.S. (1993). Endothelial activation by hydre en peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I. Am. J. Pathol. 142, 1598-1609. 

An unknown antigen presented by the major histocompatibility complex (MHC) class II molecules causes T cells to become autoreactive (Fig. 26-1). Once activated, T cells penetrate the... 

Family history of RA. Genetic studies demonstrate a strong correlation between RA and the presence of major histocompatibility complex class II human leukocyte antigens (HLA), specifically HLA-DR1 and HLA-DR4.4,5 HLA is a molecule associated with the presentation of antigens to T lymphocytes. 

Yong, V. W. and Antel J. P. Major histocompatibility complex molecules on glial cells. Semin. Neurosci. 4 231-240, 1992. 

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