M-Methyl-D-aspartate

Mclnnis J., Wang C., Anastasio N., Hultman M., Ye Y., Salvemini D., and Johnson K. M. (2002). The role of superoxide and nuclear factor-/cB signaling in M-methyl-D-aspartate-induced necrosis and apoptosis. J. Pharmacol. Exp. Ther. 301 478 187. 

Brodin, L., H.G.C. Traven, A. Lansner, P. Wallen, O. Ekeberg, and S. Grillner (1991). Computer simulations of M-methyl-d-aspartate receptor-induced membrane properties in a neuron model. J. Neurophysiol. 

NMD A receptors are selectively activated by A/-methyl-D-aspartate (NMD A) (182). NMD A receptor activation also requires glycine or other co-agonist occupation of an allosteric site. NMDAR-1, -2A, -2B, -2C, and -2D are the five NMD A receptor subunits known. Two forms of NMDAR-1 are generated by alternative splicing. NMDAR-1 proteins form homomeric ionotropic receptors in expression systems and may do so m situ in the CNS. Functional responses, however, are markedly augmented by co-expression of a NMDAR-2 and NMDAR-1 subunits. The kinetic and pharmacological properties of the NMD A receptor are influenced by the particular subunit composition. 

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Deiva K, Geeraerts T, Salim H, Leclerc P, Hery C, Hugel B, Freyssinet JM, Tardieu M (2004) Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur J Neurosci 20(12) ... 

Pittalnga A, Pattarini R, Severi P, Raiteri M (1996) Hnman brain N-methyl-D-aspartate receptors regnlating noradrenaline release are positively modnlated by HIV-1 coat protein gpl20. Aids 10(5) 463 68... 

Antonov S. M. and Johnson J. W., Permeant ion regulation of IV-methyl-D-aspartate receptor channel block by Mg(2+). Proc. Natl. Acad. Sci., 96, 14571-14576, 1999. 

Jacocks, H.M. and Cox, B.K., Serotonin-stimulated [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine, J. Pharmacol. Exp. Ther., 262, 356, 1992. 

Schilstrom, B., Nomikos, G.G., Nisell, M., Hertel, P., Svensson, T.H. A-Methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience. 82 781, 1998. 

Fedele, E., Varnier, G., Ansaldo, M.A., Raiteri, M. Nicotine administration stimulates the in vivo N-methyl-D-aspartate receptor/nitric oxide/cyclic GMP pathway in rat hippocampus through glutamate release. Br. J. Pharmacol. 125 1042, 1998. 

Huang, Y. S., Jung, M. Y., Sarkissian, M., and Richter, J. D. (2002). N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses. EMBOJ. 21, 2139-2148. 

H. Yokoyama, N. Mori, N. Kasai, T. Matsue, I. Uchida, N. Kobayashi, N. Tsuchihashi, T. Yoshimura, M. Hiramatsu, and S.I. Niwa, Direct and continuous monitoring of intrahippocampal nitric oxide (NO) by an NO sensor in freely moving rat after N-methyl-D-aspartic acid injection. Denki Kagaku 63, 1167-1170 (1995). 

Moon, I. S., Apperson, M. L. and Kennedy, M. B. The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B. Proc. Natl Acad. Sci. U.S.A. 91 3954-3958,1994. 

Harrison, N. L. and Simmonds, M. A. (1985) Quantitative studies on some antagonists of N-methyl-D-aspartate in slices of rat cerebral cortex. Br. J. Pharmacol. 84, 381-391. 

Coleman BR, Ratcliffe R, Oguntayo S, Shi X, Doctor B, Gordon R, Nambiar M. (2008) [-i-]-Huperzine A treatment protects against A-methyl-d-aspartate-induced seizure/status epilepticus in rats. Chembiol Interact 175 387-395. 

Bach, A., Chi, C.N., Olsen, T.B., Pedersen, S.W., Roder, M.U., Pang, G.F., Clausen, R.P., Jemth, P. and Stromgaard, K. (2008) Modified Peptides as Potent Inhibitors offhe Postsynaptic Density-95/ N-Methyl-d-Aspartate Receptor Interaction. Journal of Medicinal Chemistry, 51, 6450-6459. 

Morris RGM, Anderson A, Lynch GS, Baudry M (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist APS. Nature 319 774-776... 

Hough, C.J., Irwin, R.P., Gao, X.M., Rogawski, M.A., and Chuang, D.M. (1996) Carbamazepine inhibition of N-methyl-D-aspartate-evoked calcium influx in rat cerebellar granule cells./ Pharmacol Exp Ther 276 143-149. 

Chuang DM, Gao X-M, Paul SM N-methyl-D-aspartate exposure blocks glutamate toxicity in cultured cerebellar granule cells. Mol Pharmacol 42 210-216, 1992 Chugh Y, Saha N, Sankaranarayanan A, et al Enhancement of memory retrieval and attenuation of scopolamine-induced amnesia following administration of S-HTj antagonist ICS 205-930. Pharmacol Toxicol 69 105-106, 1991 Ciraulo DA, Jaffe JH Tricyclic antidepressants in the treatment of depression associated with alcoholism. Clin Psychopharmacol 1 146, 1981 Ciraulo DA, Barnhill JG, Jaffe JH Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers. Pharmacol Ther 43 539-548, 1988... 

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Paul lA, Layer RT, Skolnick P, et al Adaptation of the N-methyl-D-aspartate receptor complex in rat front cortex following chronic treatment with electroconvulsive shock or imipramine. Eur J Pharmacol 247 305-312, 1993 Paul SM, Purdy RH Neuroactive steroids. FASEB J 6 2311-2322, 1992 Paul V, Balasubramaniam E, Kazi M The neurobehavioural toxicity of endosulfan in rats a serotonergic involvement in learning impairment. Eur J Pharmacol 270 1-7, 1994... 

Yun. H.Y., Gonzalez-Zulueta, M., Dawson, V.L. and Dawson, T.M. Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras (1998) Proc Natl Acad Sd U S A 95,... 

Ahmed, M . S., Mather, A., Enna, S. J. Binding of pHJdesglycinyl remacemide to rat brain membranes association with the benzomorphan attachment site of the N-methyl-D-aspartic acid receptor channel, Brain Res. 1999, 8, 46-50. 

Allen, R. M. and Dykstra, L. A. N-Methyl-D-aspartate receptor antagonists potentiate the antinociceptive effects of morphine in squirrel monkeys, J. Pharmacol. Exp. Ther. 2001, 298, 288-297. 

M., White, H. S., Palfreyman, M. G. Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site, Mol. Pharmacol. 1990, 38, 554-561. 

Chizh, B. A., Schlutz, H., Scheed, M., Englberger, W. The N-methyl-D-aspartate antagonistic and opioid components of D-methadone antinociception in the rat spinal cord, Neurosci. Lett. 2000, 296, 117-120. 

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