Toxicity glutamate

Rordorf, B., Koroshetz, W.J., and Boventre, J.V, (1991). Heat shock protects cultured neurons from glutamate toxicity. Neuron 7, 1043-1051. 

Murphy, T.H., Miyamoto, M., Sastre, A., Schnaar, R.L. and Coyle, J.T. (1989). Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2, 1547-1558. 

Interest in the therapeutic potential of drugs acting on the NMDA receptor has risen with the discovery that epilepsy and related convulsive states may occur as a consequence of a sudden release of glutamate. Sustained seizures of the limbic system in animals result in brain damage that resembles the changes seen in glutamate toxicity. Similar changes are... 

Chuang DM, Gao X-M, Paul SM N-methyl-D-aspartate exposure blocks glutamate toxicity in cultured cerebellar granule cells. Mol Pharmacol 42 210-216, 1992 Chugh Y, Saha N, Sankaranarayanan A, et al Enhancement of memory retrieval and attenuation of scopolamine-induced amnesia following administration of S-HTj antagonist ICS 205-930. Pharmacol Toxicol 69 105-106, 1991 Ciraulo DA, Jaffe JH Tricyclic antidepressants in the treatment of depression associated with alcoholism. Clin Psychopharmacol 1 146, 1981 Ciraulo DA, Barnhill JG, Jaffe JH Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers. Pharmacol Ther 43 539-548, 1988... 

Cazevieille C., Muller A., Meynier F., Dutrait N., and Bonne C. (1994). Protection by prostaglandins from glutamate toxicity in cortical neurons. Neurochem. Int. 24 395-398. 

Glutamate Toxicity and Production of Free Radicals and Lipid Peroxides... 

Endogenous BDNF-TrkB signaling in glutamate-mediated neurotransmission may be involved in consolidation of information at the synapse. Recent studies also indicate that sustained synthesis of the immediate early gene Arc, activity-regulated cytoskeleton-associated protein, during glutamate toxicity protracts the... 

A speculative description indicates that glutamate toxicity may have three stages induction, amplification, and expression (Choi, 1990). Neurochemical events in... 

Pereira C. F. M. and Resende de Oliveira C. (2000). Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis. Neurosci. Res. 37 227-236. 

Pereira C. M. F. and Resende de Oliveira C. (1997). Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress. Free Radic. Biol. Med. 23 637-647. 

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