Human neurons

Deiva K, Geeraerts T, Salim H, Leclerc P, Hery C, Hugel B, Freyssinet JM, Tardieu M (2004) Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur J Neurosci 20(12) ... 

Coughlan CM, McManus CM, Sharron M et al (2000) Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons. Neuroscience 97 591-600 Cunha FQ, Lorenzetti BB, Poole S, Ferreira SH (1991) lnterleukin-8 as a mediator of sympathetic pain. Br J Pharmacol 104 765-767... 

Hatori K, Nagai A, Heisel R, Ryu JK, Kim SU (2002) Fractalkine and fractalkine receptors in human neurons and gfial cells. J Neurosci Res 69 418 26 Herzberg U, Sagen J (2001) Peripheral nerve exposure to HIV viral envelope protein gpl20 induces neuropathic pain and spinal gliosis. J Neuroimmunol 116 29-39... 

Hatoii K, Nagai A, Heisel R et al (2002) Eractalkine and fractalkine receptors in human neurons and glial cells. J Neurosci Res 69 418-426... 

Rock RB, Hu S, Sheng WS, Peterson PK (2006) Morphine stimulates CCL2 production by human neurons. J Neuroinflammation 3 32... 

Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, Volk C et al. Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol 1998 54(2) 342—352. 

Nelson, P. T., Hatzigeorgiou, A. G., and Mourelatos, Z. (2004). miRNP mRNA association in polyribosomes in a human neuronal cell line. RNA 10, 387—394. 

Heacock, A.M., Uhler, M. D. and Agranoff, B. W. Cloning of CDP-diacylglycerol synthase from a human neuronal line. /. Neurochem. 67 2200-2203,1996. 

Trotti, D., Nussberger, S., Volterra, A., and Hediger, M. A. (1997) Differential modulation of the uptake currents by redox interconversion of cysteine residues in the human neuronal glutamate transporter EAAC1. Eur. J. Neurosci. 9,2207-2212. 

Savic, I., Berglund, H., Gulyas, B. and Roland, P. (2001) Smelling of odourous sex hormone-like compounds causes sex-differentiated hypothalamic activation in humans. Neuron 31, 661-668. 

A more complete analysis of human neuronal NOS gene was made by Hall s group71. It is a gene of 29 exons a flanking region of over 1500 bp was determined 5- and several... 

Mehl M, Bidmon HJ, Hilbig H, ZiUes K, Dringen R, et al. 1999. Prostacyclin synthase is localized in rat, bovine and human neuronal brain cells. Neurosci Fett 271 187-190. 

Gentry CL, Lukas RJ (2002) Regulation of nicotinic acetylcholine receptor numbers and function by chronic nicotine exposure. Curr Drug Targets CNS Neurol Disord 1 359-385 Gerzanich V, Wang F, Kuryatov A, Lindstrom J (1998) Alpha 5 subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors. J Pharmacol Exp Ther 286 311-320... 

Kyong Pyo, H., Lovati, E., Pasinetti, G.M., Ksiezak-Reding, H. (2004) Phosphorylation of tau at THR212 and SER214 in human neuronal and gUal cultures the role of AKT. Neuroscience, 127, 649-658. 

Overall sequences, similarity between the constitutive endothelium and neuronal NOS isoforms is approximately 50%, and both are roughly 50% identical to the inducible macrophage NOS (Xie et al., 1992 Lamas et al., 1992). Studies have located the genes for human neuronal, endothelial, and inducible NOS on... 

Lee, Y. T. and Wang, Q. Inhibition ofhKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid, Eur. J. Pharmacol. 1999, 378, 349-356. 

Very primitive multicellular organisms, such as the hydra (e.g., Chlorohydra viriiissima, the ultimate simple feeding tube), have nervous systems that may only use simple proteins as neurotransmitters, suggesting that these proteins were the first signaling molecules used by primordial nervous systems. If we extract a few of these proteins from the brain of a typical Hydra and inject them in human neurons, they will actually produce similar signaling responses from those neurons. 

GSH protects human neuronal cells from dopamine-induced apoptosis. The role of GSH and other antioxidants in dopamine-induced apoptosis in cultures of the human neuronal cell line has been studied. Apoptosis, induced by 0.1 to 0.3 mM dopamine, was blocked by GSH in a dose- and time-dependent manner. This was observed by monitoring cell morphology, cell viability, and the... 

Chavez-Noriega, L. E., Crona, J. H., Washburn, M. S., Urrutia, A., Elliot, K. J., Johnson, E. C. Pharmacological Characterization of Recombinant Human Neuronal Nicotinic Acetylcholine Receptors hoi2(32, hoi2(34, ha3(34, hoi4(32, hoi4(34 and ha7 Expressed in Xenopus Oocytes. 

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