Lymphomas lymphocytic lymphoma

Hodgkin s disease, lymphocytic lymphoma, histiocytic lymphoma, mycosis fungoides, testicular cancer, Kaposi s sarcoma, breast cancer Acute leukemia, combination therapy for various cancers... 

Precursor B-cell neoplasm Precursor B-lymphoblastic leukemia/lymphoma Mature (peripheral) B-cell neoplasms B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma... 

Nodular sclerosis Hodgkin s lymphoma (grades 1 and 2) Lymphocyte-rich classical Hodgkin s lymphoma Mixed cellularity Hodgkin s lymphoma Lymphocyte depletion Hodgkin s lymphoma... 

Hainsworth, J.D., Litchy, S., Barton, J.H., Houston, G.A., Hermann, R.C., Bradof, J.E., and Greco, RA., Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma a phase II trial of the Minnie Pearl Gancer Research Network, /. Clin. Oncol., 21,1746-2751, 2003. 

Vandewoestyne ML, Pede VC, Lambein KY et al (2011) Laser microdissection for the assessment of the clonal relationship between chronic lymphocytic leukemia/smaU lymphocytic lymphoma and proliferating B cells within lymph node pseudofolKcles. Leukemia 25 883-888... 

Corticosteroids suppress proliferation of lymphocytic cells, thus they are useful at combating acute lymphoblastic or undifferentiated leukemia of childhood, chronic lymphocytic leukemia, Hodgkin s lymphoma, other lymphomas. Therapy is often initiated with a steroid in combination with other agents. There is no evidence of cross resistance to unrelated agents. Mostly prednison is used however at appropriate dosages similar effects can be obtained with other glucocorticosteroids. 

B cell neoplasms based on morphology, immunophenotype, and genotype often, but not always, correspond to stages of B cell development. However, some B cell lymphomas either do not clearly correspond to a specific developmental stage (i.e., appear to be of variable origin such as chronic lymphocytic leukemia/small lymphocytic lymphoma) or do not appear to be related to any known stage of normal development (i.e., hairy cell leukemia) (H10). 

CLL/SLL, Chronic lymphocytic leukemia/small lymphocytic lymphoma MCL, mantle cell lymphoma FL, follicular lymphoma MZL/MALT, marginal zone lymphoma/mucosa-associated lymphoid tisuse lymphoma SMZL, splenic marginal zone lymphoma HCL, hairy cell leukemia DLCL, diffuse large-cell lymphoma PCM, plasma cell myeloma BCL-1, cyclin D1 FDC MW, Follicular dendritic cell meshworks CK, cytokeratin LELs, lymphoepitheilal lesions. 

D26. Dunphy, C. H., Wheaton, S. E., and Perkins, S. L., CD23 expression in transformed small lymphocytic lymphomas/chronic lymphocytic leukemias and blastic tranformations of mantle cell lymphoma. Mod. Pathol. 10, 818-822 (1997). 

K8. Kilo, M. N., and Dorfman, D. M., The utility of flow cytometric immunophenotypic analysis in the distinction of small lymphocytic lymphoma/chronic lymphocytic leukemia from mantle cell lymphoma. Am. J. Clin. Pathol. 105, 451—457 (1996). 

K30. Kroft, S. H., Dawson, D. B., and McKenna, R. W., Large cell lymphoma transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma. A flow cytometric analysis of seven cases. Am. J. Clin. Pathol. 115, 385-395 (2001). 

Human non-Hodgkin s lymphoma lymphocytes 3.7 Monti et al., 1981b... 

Non-Hodgkin s lymphomas are further classified as lymphocytic or histiocytic. Lymphocytic lymphomas may be poorly differentiated (according to the extent to which they have evolved from the pluri potential stem cell) they may also be nodular (concentrated) or diffuse. 

Rare, but occasionally very serious, adverse effects include hepatotoxicity, respiratory depression, seizures, pleuropericardial reaction, and lymphocytic lymphoma (SEDA-5, 137). 

Perkins JG, Flynn JM, Howard RS, Byrd JC. Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma implications for clinical trials in this patient population. Cancer 2002 94(7) 2033-9. 

Leroux D, Le Marc Hadour F, Gressin R, Jacob MC, Keddari E, MonteE M, et al. Non-Hodgkin s lymphomas with t(ll 14)Cql3 q32) a subset of mantle zone/intermediate lymphocytic lymphoma Br J Haematol 1991 77 346-53. 

Rimokh R, Berger F, Delsol G, Charrin C, Bertheas MF, French M, et al. Rearrangement and overexpression of the BCL-l/PRAD-1 gene in intermediate lymphocytic lymphomas and in tfllql 3)-bearing leukemias. Blood 1993 81 3063-7. 

Weisenburger DD, Sanger WG, Armitage JO, Purtilo DT. Intermediate lymphocytic lymphoma immunophenotypic and cytogenetic findings. Blood 1987 69 1617-21. 

Corticosteroid hormones are also useful anticancer agents because of their lymphotoxic effects. Their primary use is in management of hematologic mahgnancies, especially lymphomas, lymphocytic leukemias, and multiple myeloma. In addition to their cytotoxic effects, corticosteroids have many other applications in... 

European phase II study of rituximab (chimeric anti-CD20 monoclonal antibody) for patients with newly diagnosed mantle-cell lymphoma and previously treated mantle-cell lymphoma, immunocytoma, and small B-cell lymphocytic lymphoma. 

PURPOSE Mantle-cell lymphoma (MCL), immunocytoma (IMC), and small B-cell lymphocytic lymphoma (SLL) are B-cell malignancies that express CD20 and are incurable with standard therapy. 

FIGURE 1.19 (A, B) B5-fixed section of bone marrow aspirate depicting a small solitary nodule consisting of lymphocytes and occasional plas-macytoid lymphocytes, with scattered plasma cells around it. Many of the lymphoid and plasmacytoid cells reacted strongly with anti-lambda antibody (A). Anti-kappa reacted only with scattered plasma cells outside the nodule (B, small black dots). This patient eventually was shown to have a solitary plasmacytoid lymphocytic lymphoma in the small intestine (also lambda type). Paraffin sections, DAB with hematoxylin counterstain (xl 25). There was no serum paraprotein detectable at this time presumably the number of tumor cells was insufficient for production of a detectable paraprotein however, a "monoclonal" IgM appeared later in the course. From Taylor CR, Cote Rj. Immunomicroscopy A Diagnostic Tool for the Surgical Pathologist 2nd ed. Philadelphia WB Saunders 1994 59. 

Ramnani D, Lindberg G, Gokaslan ST, et al. Signet-ring cell variant of small lymphocytic lymphoma with a prominent sinusoidal pattern. Ann Diagn Pathol. 1999 3 220-226. 

CD25 functions as a low-affinity interleukin-2 receptor and may be found on a number of cell types including activated T cells. This antigen is characteristically expressed on hairy cell leukemia, mast cell lesions, and certain T-cell malignancies but may be seen at low levels in certain B-cell lymphomas, particularly small cell lymphocytic lymphoma/chronic lymphocytic leukemia. Targeted therapy is available for this antigen (Ontak). 

B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA... 

INTERPHASE FISH Several recurrent genetic abnormalities identified in small cell lymphocytic lymphoma/chronic lymphocytic leukemia have had a direct relationship to disease progression. These abnormalities are ... 

Of particular interest is the 17p deletion, which is thought to be associated with p53 deletion. This abnormality confers the worse prognosis of any of the above-listed abnormalities but also seems to indicate therapy selection. This abnormality confers fludarabine resistance and there is evidence to suggest that first-line therapy treatment with Campath would be indicated. These abnormalities may be detected in up to 80% of cases of small cell lymphocytic lymphoma. 

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