Nodular lymphocyte predominant Hodgkin lymphoma

Nodular lymphocyte-predominant Hodgkin s lymphoma Classical Hodgkin s lymphoma... 

Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)... 

Hodgkin lymphoma (HL) is widely accepted to be a malignant clonal proliferation of B lymphocytes or, less often, T lymphocytes surrounded by variable numbers of inflammatory cells and fibrosis. The two major histologic types are classical Hodgkin lymphoma (CHL) and nodular lymphocyte predominance Hodgkin lymphoma (NLPHL). Classical Hodgkin lymphoma is further subdivided into four subtypes ... 

FIGURE 5.2 Nodular lymphocyte predominance Hodgkin lymphoma. (A) Low magnification showing nodular pattern. (B) Popcorn variants of Hodgkin/Reed-Sternberg cells. 

FIGURE 5.8 Leu7+ (CD57+) T lymphocytes surrounding Hodgkin/ Reed-Sternberg cells in nodular lymphocyte predominance Hodgkin lymphoma. 

Prakash S, Fountaine T, Raffeld M, et al. IgD positive L H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma. Am J Surg Pathol. 2006 30 585-592. 

Kamel OW, Gelb AB, Shibuya RB, et al. Leu 7 (GD57) reactivity distinguishes nodular lymphocyte predominance Hodgkin s disease from nodular sclerosing Hodgkin s disease, T-cell-rich B-cell lymphoma and follicular lymphoma. Am J Pathol. 1993 142(2) 541-546. 

Menestrina F, Chilosi M, Scarpa A. Nodular lymphocyte predominant Hodgkin s disease and anaplastic large cell (CD30+) lymphoma Distinct entities or nonspecific patterns Semin Diagn Pathol. 1995 12 256-269. 

Recently few interesting observations show that clonality analyses may be also useful to analyze some types of classical Hodgkin s lymphoma, namely nodular sclerosis and lymphocyte predominance type, as the vast majority of the neoplastic L H cells (about 95%) proved to be of B-cell origin, i.e. from germinal center B-lymphocytes. The rest ( 5%) of L H cells seems to be of T- or null-cell origin. The IgH rearrangement is found in up to 20% of Hodgkin s lymphoma types. 

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