Brown-Norway rats

Friedmann, A.S., H. Chen, L.D. Rabuck, and B.R. Zirkin. 1998. Accumulation of dietary methylmercury in the testes of the adult brown Norway rat impaired testicular and epididymal function. Environ. Toxicol. Chem. 17 867-871. 

Knippels, L.M. and Penninks, A.H., Assessment of the allergic potential of food protein extracts and proteins on oral application using the brown Norway rat model, Environ. Health Perspect., 11, 233, 2003. 

Ezendam, J. et al., Toxicogenomics of subchronic hexachlorobenzene exposure in Brown Norway rats, Environ. Health. Perspect., 112, 782, 2004. 

Brown Norway rat HgCl2 AU-salts D-Penicillamine Nevirapine HCB IC-glomerulonephritis Skin pathology, dermatitis Polyclonal IgE AutoAb (Type IV-collagen, ANA, 1 anti-ACh, thyroglobulin) Systemic inflamatory response with autoimmune symptoms... 

Donker, A. J. et al., Effects of prolonged administration of D-penicillamine or captopril in various strains of rats. Brown Norway rats treated with D-penicillamine develop autoantibodies, circulating immune complexes, and disseminated intravascular coagulation. Clin. Immunol. Immunopathol., 30, 142, 1984... 

Tournade, H., et al., (1990) D-penicillamine-induced autoimmunity in Brown-Norway rats. Similarities with HgC12-induced autoimmunity. J. Immunol.,144, 2985, 1990... 

Qasim, F.J., Thiru, S., and Gillespie, K.,Gold and D-penicillamine induce vasculitis and up-regulate mRNA for IL-4 in the Brown Norway rat Support for a role for Th2 cell activity. Clin. Exp. Immunol., 108,438, 1997... 

Hirsch, F. et al., Autoimmunity induced by HgC12 in Brown-Norway rats. I. Production of monoclonal antibodies. J. Immunol., 136, 3272, 1986. 

Aten, J. et al., (1988) Mercuric chloride-induced autoimmunity in the brown Norway rat. Cellular kinetics and major histocompatibility complex antigen expression. Am. J. Pathol., 133, 127, 1988... 

Szeto, C., Gillespie, K.M., and Mathieson, P.W., Low-dose mercuric chloride induces resistance in brown norway rats to further mercuric chloride by up-regulation of interferon-gamma. Scand. J. Immunol., 50, 195, 1999. 

Mathieson, P. W. et al., Immunoregulation of mercuric chloride-induced autoimmunity in Brown Norway rats A role for CD8+ T cells revealed by in vivo depletion studies. Eur. J. Immunol., 21, 2105, 1991. 

Masson, M.J., and Uetrecht, J.P., Tolerance induced by low dose D-penicillamine in the brown Norway rat model of drug-induced autoimmunity is immune-mediated. Chem. Res. Toxicol., 17, 82, 2004. 

Sayeh, E., and Uetrecht, J.P., Factors that modify penicillamine-induced autoimmunity in Brown Norway rats Failure of the Thl/Th2 paradigm. Toxicology, 163, 195, 2001. 

Ezendam, J., Vos, J., and Pieters, R., Mechanisms of Hexachlorobenzene-induced adverse immune effects in Brown Norway rats. J. Immunotoxicol., 1, 167, 2004. 

Warbrick, E.V., Dearman, R.J. and Kimber, I., Induced changes in the total serum IgE concentration in the Brown Norway rat Potential for identification of chemical respiratory allergens. J. Appl. Toxicol., 22, 1, 2002. 

Atkinson, H.A.C. and Miller, K., Assessment of the Brown Norway rat as a suitable model for investigation of food allergy. Toxicology, 91, 281, 1994. 

Miller, K., Meredith, C, Selo, I. amd Wal, J-M., Allergy to P-lactoglobulin specificity of immunoglobulin E generated in the Brown Norway rat to tryptic and synthetic peptides. Clin. Exp. Allergy., 29, 1696, 1999. 

Pilegaard, K. and Madsen, C., An oral Brown Norway rat model for food allergy comparison of age, sex, dosing volume, and allergen preparation. Toxicology, 196, 247, 2004. 

Akiyama, H., Teshima, R., Sakushima, J., Okunuki, H., Goda, Y., Sawada, J., Toyoda, M., Examination of oral sensitisation with ovalbumin in Brown Norway rats and three strains of mice. Immunol. Lett., 78, 1, 2001. 

Bellon, B., Capron, M., Druet, E., Verroust, P., Wial, M.C., Sapin, C., Girard, J.F., Foidart, J.M., Mahieu, P. and Druet, R (1982). Mercuric chloride induced autoimmune disease in Brown-Norway rats Sequential search for anti-hasement membrane antibodies and circulating immune complexes. Eur. J. Clin. Invest. 12 127-133. 

Rat Genome Sequencing Project Gonsortium. 2004. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428 493. 

Spanhaak, S. and Penninks, A.H. (1999) An oral sensitization model in Brown Norway rats to screen for potential allergenicity of food proteins. Methods (San Diego, Calif), 19, 78-82. 

CN205 Ju, H. R., H. Y. Wu, S. Nishizono, M. Sakono, I. Ikeda, M. Sugano, and K. Imaizumi. Effects of dietary fats and curcumin on IgE-mediated degranulation of intestinal mast cells in brown Norway rats. Biosci Biotechnol Biochem 1996 60(11) 1856-1860. 

In rat liver, 1,2-dimethylhydrazine had no consistent effect on the relative focal volume of y-glutamyltranspeptidase-positive preneoplastic foci (Denda et al., 1988). Locniskar et al. (1985) treated Brown-Norway and Fischer rats with 150 mg/kg bw 1,2-dimethylhydrazine by gavage five times over a three-week period. Five months after the final treatment, isolated splenic, colonic intraperithelial lymphocytes and lamina propria lymphocytes from the Brown-Norway strain exhibited low natural killer cell activity and reduced splenic T-lymphocyte proliferation in response to autologous non-T lymphocytes. Furthermore, colonic lamina propria lymphocyte proliferation was low, and Brown-Norway rats had a low incidence of 1,2-dimethylhydrazine-induced colonic neoplasms (7%) in comparison with Fischer rats, which had more effective splenic and colonic intraperithelial lymphocyte natural killer cell activity, enhanced splenic autologous mixed lymphocyte response, enhanced colonic lamina propria lymphocyte proliferation and a higher incidence of colon tumours (20%). 

Fig. 1.4 The bronchoconstrictor effects of adenosine, NECA, CPA, CGS 21680 and 2-C1-IB-MECA in actively sensitised, Brown Norway rats 3 h post intratracheal instillation of vehicle (saline, 0.2 ml) or ovalbumin (OA, 0.3 mg kg-1). The agonists were given i.v. and to avoid tachyphylaxis, only one response was generated per animal. Results are expressed as means s.e. means (n = 4—5). P < 0.01, P < 0.001 that the value is significantly different from the equivalent value in the vehicle-challenged group (from Hannon et al. 2002b, with permission)...

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