Tumor regression

Integrin otvfi3 Antagonists Promote Tumor Regression by Inducing Apoptosis of Angiogenic Blood Vessels... 

Antagonists of integrin av 33 inhibit the growth of new blood vessels into tumors cultured on the chick chorioallantoic membrane without affecting adjacent blood vessels, and also induce tumor regression [7]. Antagonists of av 33 also inhibit angiogenesis in various ocular models of retinal neovascularization [7]. 

Fig. 4 Polypeptide hybrid vesicle that was used to load DOX. (a) Representation of the hyaluronan-h-poly(y-benzyl glutamate) vesicle. Adapted from [50] with permission. Copyright 2009 American Chemical Society, (b) Tumor regression data after administration of free DOX and DOX-loaded hyaluronan-h-poly(y-benzyl glutamate) vesicles (PolyDOX). Reprinted from [80] with permission. Copyright 2010 Elsevier...

Generally, changes in the tumor marker concentration reflect changes in tumor burden. It has been reported that an increase in the tumor marker concentration is associated with tumor recurrences. An increase of 25 percent or more can be due to tumor progression. Similarly, a decrease could be due to tumor regression or response to therapy (18, 28, 32). 

Koppu S, Oh YJ, Edrada-Ebel R, Blatchford DR, Tetley L, Tate RJ, Dufes C (2010) Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA. J Control Release 143 215-221... 

Attia, P. et al., Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4, J. Clin. Oncol., 23 6043, 2005. 

Humphrey and Seal9 (U.S.A.) reported in 1959 detailed experiments on the ECT of sarcoma-180 tumors in nearly 500 mice. In a typical experiment, 18 test animals and 18 control animals were used the ECT was done with 3 ma current, at 6 V for 3 hours a day, for 24 days. They observed that after such a lengthy treatment, the mean volume of test tumors was about 15% of the mean tumor volume of the control group seven mice showed complete tumor regression as a result of ECT. Total regression means that the tumor has decreased progressively in volume, hardened, dropped off, leaving a new skin surface at the former tumor site. 

Griffin and coworkers (U.K.) reported work on ECT of mammary carcinoma in mice.67 Tumor destruction was found to be significantly greater, for a given charge, when anode was implanted in the tumor with cathode outside it. The results demonstrated a linear relationship between the volume of tumor regression induced and the quantity of electric charge passed. 

Folkman J, Langer R, Linhardt RJ, Haudenschild C, Taylor S (1983) Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Science 221 719-725. 

About a 100 years ago, Coley observed tumor regression after application of a mixture of bacterial toxins. This experiment made the foundation of immune therapy for cancer, which only recently became a promising treatment and an efficient alternative to chemotherapy. In contrast to chemotherapy (1), this new treatment does not kill tumor cells directly rather it enhances the sensitivity of the patient s own immune system against tumor cells with all the potential positive aspects like high selectivity of treatment and much less side effects (2). 

To review, in an experimental mouse model, LPDI/E7 vaccination both prevents the establishment of metastatic E7-expressing tumors in naive mice through an induced E7-specific T-cell immune response and, in mice with previously established E7-expressing tumors, causes tumor regression with one subcutaneous injection of LPDI/E7 [Han SJ, et al. Subcutaneous antigen loading of dendritic cells by liposome-protamine-DNA (LPD) nanoparticles results in their activation and induction of specific antitumor immune response (impublished)]. A robust immune response follows administration of LPDI/ peptide particles, which can be used as either a preventative or therapeutic cancer vaccination strategy due to the ability of the particles to prevent and eliminate tumors, respectively, in mouse models. 

Krasnici S, et al. Effect of the surface charge of liposomes on their uptake by angiogenic tumor vessels. Int J Cancer 105, 561, 2003 Hood J, et al. Tumor regression by targeted gene delivery to the neovasculature. Science 2002 296 2404. 

Mouse xenograft—100 mg/kg Partial tumor regression Tumor stasis... 

In precHnical models, ARRY-142886 treatment results in either tumor regression or stasis in xenograft models of colorectal, non-small cell lung, pancreatic, breast, and melanoma cancers. Most of these cell lines contain either the B-Raf or K-Ras mutations. Complete inhibition of pERKl/2 formation in excised tumors from both HT-29 and BxPC3 studies was achieved 4 h after an oral dose of 20 mg/kg/day ARRY-142886 [114]. In a separate HT-29 study, a PK/PD relationship was established [115]. Twelve hours after a single 30 mg/kg oral dose of ARRY-142886, approximately 80% inhibition of ERKl/2 phosphorylation was observed with a corresponding plasma concentration of about 0.60 xg/ml. In the same study at 24 h, ERKl/2 phosphorylation was... 

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