Chronic lymphatic leukemia

In the Pre-Carpathian biogeochemical province with prevalent Eutric Podsolu-visols, enriched in lead and barium and depleted in chromium and vanadium, the predominant diseases are mieloleukemia, chronic lymphatic leukemia, hemorrhagic vasculitis, hypoanemia with a relatively low number of sharp leukemia, lung and stomach cancer. 

Serum Iq s in Other Lymphoid Neoplasia— Hodgkin s Disease, Reticulum Cell Sarcoma, Lymphosarcoma, and Chronic Lymphatic Leukemia... 

Chlorambucil is well adsorbed when administered orally. It is used for chronic lymphatic leukemia and for multiple myelomas. Synonyms of this drug are leukeran, amboclorin, and others. 

For leukemic forms no interrelation was found between metabolite abnormality and behavior of the peripheral blood picture. In 4 cases with chronic myeloid leukemia, a tremendous increase in the leucocyte counts (300,000 in one subject) did not correspond to any abnormal excretion. Kynurenine excretion is, however, frequently increased in patients with chronic lymphatic leukemia, which is related to the malignant lymphogranuloma through the same genesis of the lymphoreticular matrix. 

Pauwels, M., Pauwels, S., Capron, XR, Sevestre, H., Desablens, B. Intra-hepatic portal hypertension during chronic lymphatic leukemia. Gastroenterol. Clin. Biol. 2000 24 221—224... 

Patients with chronic lymphatic leukemia or with concurrent infection with Epstein-Barr virus or HIV have an increased frequency of ampicillin- and amoxicillin-associated rashes (280). 

Myeloschisis occurred in a 6-week-old human embryo whose 39-year-old mother had taken busulfan before and during the early stages of gestation for chronic lymphatic leukemia (36). Histology showed reduced mesenchymal elements together with somite disorganization in the affected area of the embryo. 

The antileukemic effect of ciclosporin has been harnessed in the treatment of cytopenias associated with chronic lymphatic leukemia. In 31 patients the most common adverse effect was a raised serum creatinine concentration of grade 2 or worse in six patients (19%) three patients developed opportunistic infections (4). 

Fludarabine can cause or exacerbate autoimmune thrombocytopenia in chronic lymphocytic leukemia. Two patients with chronic lymphatic leukemia who developed thrombocytopenia while taking fludarabine were treated... 

A second malignancy in a patient taking methotrexate for chronic lymphatic leukemia has been described (123). 

The authors thought that T cell deficiency induced by methotrexate, chronic lymphatic leukemia, and rheumatoid arthritis may have contributed to the development of the B cell lymphoma. 

Trade names Ribomustin (Mundipharma) Treanda (Cephalon) Indications Chronic lymphatic leukemia Category Alkylating agent Half-life 40 minutes... 

Lymphoid neoplasia 10% Reticulosarcoma 12% Mycosis fungoides 9% Hodgkin s disease 34% Lymphosarcoma 40% Giant follicular lymphoma 60% Chronic lymphatic leukemia Spindle cell thymoma... 

Bundles, Coonrad, and Arends (R13) surveyed 35 patients with leukemia and detected paraproteins in at least 4, and possibly in 2 others. Since then there have been numerous reports of paraproteinemia with all kinds of lymphoma or leukemia, although almost no further surveys until 1969 when 19 of 76 patients were found to have excess light-chain excretion (L6). Personal surveys have revealed serum paraproteins in 3 atypical cases out of 124 consecutive patients with Hodgkin s disease, 26 of 207 with lymphosarcoma (see Section 7.7.2), 1 of 45 with reticulo-sarcoma, 0 of 31 with giant follicular lymphoma, 3 of 84 with chronic lymphatic leukemia, 0 of 43 with chronic myeloid leukemia, 0 of 57 with acute leukemia, and 1 of 5 with chronic monocytic leukemia as established by high lysozyme levels. Urine has revealed Bence Jones proteins in many of those with serum paraproteins and in addition only Bence Jones in 1 atypical Hodgkin s, 2 lymphosarcoma, 1 giant follicular lymphoma, yet 8 with chronic lymphatic leukemia. 

The 12% of lymphoma and 10% of chronic lymphatic leukemia with paraproteins may actually represent neoplasia of the B-lymphocyte line (bursa-equivalent), i.e., true plasma cell precursors. The prognosis... 

N3. Neumann, H., Klein, E., Hauck-Granoth, R., Yachnin, S., and Ben-Bassat, H., Comparative study of alkaline phosphatase activity in lymphocytes, mitogen induced blasts, lymphoblastoid cell lines, acute myeloid leukemia and chronic lymphatic leukemia cells. Proc. Natl. Acad. Sci. U.S.A. 73, 1432-1436 (1976). 

LYMPHOHEMATOPOIETIC STUDY OF WORKERS EXPOSED TO BENZENE INCLUDING MULTIPLE MYELOMA, LYMPHOMA AND CHRONIC LYMPHATIC LEUKEMIA... 

Evidence that purine metabolism is important in the immune response has been obtained from the observation that markedly reduced or absent adenosine deaminase (ADA) activity in man has been casually associated with an autosomal recessive form of severe combined immunodeficiency disease (3). Recently, ADA levels in lymphocytes from patients with untreated chronic lymphatic leukemia have been found to be consistently lower than in lymphocytes from normal subjects (4). Children with ADA deficiency and immunodeficiency have been shown to have increased levels in plasma, urine, lymphocytes and erythrocytes of adenosine, adenine, deoxy-adenosine, adenine nucleotides, and deoxyadenine (5, 6). Although the exact biochemical mechanism(s) is unknown, elevated levels of adenosine, and/or deoxyadenosine and their metabolites are thought to be selective inhibitors of both differentiation and effector function of lymphocytes (7, 8). Adenosine was known to inhibit the PHA-induced blastogenesis of human peripheral blood lymphocytes (9) even before the discovery of the first ADA-deficient child. In addition, elevated levels of cyclic AMP (cAMP) were known to be inhibitory for lymphocyte-mediated cytotoxicity (7). Since... 

Chronic lymphatic leukemia lymphocytes (human) Cells in culture 63 Lichtman and Weed, 1970... 

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