Lung cancer case study

Perhaps the first modern analytical studies were those reported in the 1950s on the relationship between smoking and lung cancer. Richard Doll (he appears again ) and Bradford Hill, of England, were the authors of cohort studies of smokers, and Ernst Wynder and Evarts Graham, of the United States, undertook and reported case-control studies of lung cancer cases. The Doll-Hill studies are, in their... 

Sanderson WT, Ward EM, Steenland K, et al Lung cancer case-control study of beryllium workers. Am f Ind Med 39 133M4, 2001... 

Wu X, Hudmon KS, Detry MA, et al (2000) D2 dopamine receptor gene polymorphisms among African-Americans and Mexican-Americans a lung cancer case-control study. Cancer Epidemiol Biomarkers Prev 9 1021-1026... 

Nested case-control studies for lung (Barbone et al., 1992) and central nervous system (Barbone et al., 1994) neoplasms w ere conducted using the full cohort of dye and resin manufacturing workers reported on by Delzell et al. (1989). Exposure w as assessed on an ordinal scale based on job titles, w ork areas, and potential for contact. When the work histories of 51 lung cancer cases were compared with those of 102 controls matched for year of birth, an association was observed with potential epichlorohydrin... 

BCME is known to be a human carcinogen based on sufficient evidence of carcinogenicity in humans. Numerous epidemiological studies and case reports from around the world have documented that workers exposed to BCME have an increased of lung cancer. Two studies of workers exposed to BCME showed an increased risk of lung cancer, mainly small cell carcinoma. Two subsequent studies have shown a positive association between atypical cells in... 

A case-referent study of exposure to radon from the ground and bronchial cancer was carried out on 292 female lung cancer cases and 584 controls who had lived in Stockholm for 30 or more years. Lung cancer cases were diagnosed as oat cell and other types of anaplastic pulmonary carcinomas and the study concluded that radon and daughters were a significant etiologic factor in the cancers noted. 

Andjelkovich DA, Shy CM, Brown MH, et al. 1994b. Mortality of iron foundry workers. III. Lung cancer case-control study. J Occup Med 36 1301-1308. 

A mortality study by Barthel of 1658 German men who had been employed in agricultural work involving use of pesticides found 50 lung cancer cases when 27.5 were expected (SMR—2.1 90%... 

Today, radon and its decay products in indoor air are by far the most important contributors to the exposure of the public to ionizing radiation and may be responsible for as much as 10-20% of the lung cancer cases (Steindorf etal. 1995, Lubin 1994). Synergism with smoking was found in several studies, but recent assessments of the data indicate that the two agents may act in part additively. Smoking may also reduce the latent period. 

British smelter workers Cohort and nested case-control studies 4,173 Zn-Pb-Cd smelter workers, >1 year employed from 1943 to 1969, born before 1940 Nested case—control N = 174 lung cancer cases, N = 2,717 controls frequency-matched on age, work start, etc. Mean PbB in Cd operation 28 igf dl furnace PbB 59 xg/dl sinter 56 ng/dl Job-exposure matrix Lung cancers and SMRs versus work years 20—29 44, SMR = 190 (138-256) 30-39 28, SMR = 142 (94-205) >40 8, SMR = 292 (126-575) Ades and Kazantzis (1988) ... 

TABLE 5.8(c) Case-Control Studies of Lung Cancer among Workers in the Printing Industry... 

It is well known that excessive intake of P-carotene may lead to carotenodermia (yellow skin), and it is undoubtedly the case that some carotenoid is directly lost via the skin or through photo-oxidation in the skin. As far as is known the carotenoids are not cytotoxic or genotoxic even at concentrations up to 10 times the normal plasma concentration which may cause carotenodermia. However, they are associated with amenorrhoea in girls who may be consuming bizarre diets and, in long-term supplementation studies, with an increase in lung cancer (The Alpha-tocopherol, Beta-carotene Cancer Prevention Study Group, 1994). 

Petersen GR, Gilbert ES, Buchanan JA, et al. 1990. A case-cohort study of lung cancer, ionizing radiation, and tobacco smoking among males at the Hanford site. Health Phys 58(1) 3-11. 

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