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Protection liver

Sava, V.M. et al.. The liver-protecting activity of melanin-like pigment derived from black tea. Food Res. Int., 36, 505, 2003. [Pg.123]

Telleman, P, and R.P. Junghans, The role of the Brambell receptor (FcRB) in liver protection of endocytosed immunoglobulin G (IgG) from catabolism in hepatocytes rather than transport of IgG to bile. Immunology, 2000.100(2) 245-51. [Pg.287]

Many studies have related the antioxidant activity with liver protection against free radicals [245-247], although other mechanisms also contribute to the hepatoprotective action of EOs and their components [248]. [Pg.96]

Zang et al [140] reported the liver protective effects of the saponins isolated from A. membranaceus and A. sieversianus against chemical injury induced by CCU, D-galactosamine and acetaminophen in mice. In all cases there were positive activities and the saponins inhibited the rise in SGPT levels, decreased the malondialdehyde (MDA) content and increased the glutathione reduced (GSH) concentration in mouse liver. The same compounds were also evaluated in cultured rat hepatocytes, and the results indicated that the activity may be due to to the antioxidative activity of the saponins, since the content of liver protein in treated mice was more than the control. Moreover, in all treated mice, the level of hepatic microsomal cytochrome P-450 was increased. The liver metabolism and immunoregulating action produced by saponins may be also involved in their hepato-protective effects. Similar results were obtained by Zhang et al [141] when they studied the activity in vitro and... [Pg.219]

Use dctoxicant, liver protective drug, lipotropic, growth factor... [Pg.2019]

Ray and coworkers (31) studied the liver protective properties of cleomiscosins A (9), B (10) and C (7), isolated from Cleome viscosa seeds, and found significant activity against D-galactosamine-induced cytotoxicity in primary cultured rat hepa-tocytes, with 10 being the most potent of these substances. Chattopadhyay et al. (33) have patented a hepatoprotective pharmaceutical preparation (Cliv-92), composed of a mixture of three coumarinolignans isolated fi om the seeds of C. viscosa, in the optimized ratio of 3 5 2. [Pg.26]

The liver-protective effect of silymarin is multifactorial and this may be due to its antidote, antifibrogenic, membrane stabilizing, protein synthesis inducing, and signal-evoking properties (90). Silymarin and silybin (1) have also shown potential... [Pg.48]

Xenobiotic-induced liver injury has become the most frequent cause of acute liver failure in humans in the USA and around the world, exceeding all other causes combined (Watkins and Seef, 2006). Owing to its detoxification mechanisms, the liver protects the individual against xenobiotic-induced injury. Certainly, the liver toxicity caused by chemical warfare agents is a potential area of concern. [Pg.549]

IDUN Pharmaceuticals (San Diego, CA) also reported development of a potent peptidomimetic irreversible oxamyl dipeptide inhibitor lDN-6556 that uses 2,3,5,6-tetrafluro-phenoxymethylketone warhead (Fig. 2f) (37, 38). This molecule preferentially accumulates in the liver, which results in pronounced liver protection in animal models [for example, after Fas-induced liver injury (39)], and showed significant promise in clinical trials of acute alcoholic hepatitis, human liver preservation injury, and chronic hepatitis C (38, 40, 41). [Pg.171]

Similarly, there is no generally protective therapy of the liver. Liver protection as such may include active vaccination against viral hepatitis A or B, for example, and, in a wider sense, also passive immunization after exposure or general avoidance of typical liver noxae. This can protect the liver from diseases. (12)... [Pg.847]

A liver-protective preparation must therefore be capable of protecting the hepatocytes (as well as the sinus endothelium) from a particular liver toxin, or from 2 or 3 clearly defined (or, in the optimal case, all obligate) liver toxins, by administration before or, at the latest, when the damage occurs. The use of a substance in existing cellular damage would be classified as therapy and no longer protection . The term protective liver therapy clearly implies prophylaxis - which, apart from the above exceptions (e. g. vaccination), is usually not feasible under the provisions of the respective health insurance system. (12)... [Pg.847]

Buzzelll, G., Moscarella, S., Giusti, A., Duchini, A., Marena, C., Lam-pertfco, M. A pilot study on the liver protective effect of silybin-phosphatidylcholine complex (IdB 1016) in chronic active hepatitis. Int. J. Clin. Pharmacol. Ther. Toxicol. 1993 31 456-460... [Pg.888]

Silymarin has the ability to increase the regeneration of liver cells by stimulation of protein synthesis. Besides the liver-protecting action it also has choleretic, cholekinetic and spasmolytic effects. [Pg.53]

ARTICHOKE, Cynarae folium is the leaves from Cynara scolymus L., family Jisteraceae. The extract of artichoke leaves has a liver-protecting effect, increases the regeneration of liver cells and has choleretic and lipid-lowering effects. [Pg.53]

A stilbene polymer (Gn-3) isolated from Gnetum parvifolium inhibited the development of liver injury in mice caused by CCl4j N-acetyl-P-aminophenol (APAP) and Bacillus Calmette-Guerin (BCG) plus bacterial lipopolysaccharide (LPS) at a dose of 50 mg-kg d 1 sc administered for 3 d thus Gn-3 was found to have liver protective effects [74]... [Pg.629]

Aqueous fractions from P. major leaves were found to be biologically active. They activate the complement system and induced the production of tumor necrosis factor alpha (TNF-a) by human moncytes in vitro [196]. Aucubin (19) reported to have liver protective effect and it was shown to be antidote for fatal mushroom poisoning caused by Amanita phalloides. It exhibited low toxicity [197]. In India, the leaves and roots of P. major are used for their astringent properties and to bring down fever. The seeds are taken as a cure for dysentery and are considered to have stimulant effects. [Pg.279]

Glutathione Glutamate, cysteine, glycine All tissues but highest use in the liver Protection against free radical injury by reduction of hydrogen peroxide and lipid peroxides. In liver and kidney forms mercapturic acids. [Pg.850]

The detoxifying effect of different seaweeds in a Wistar rat model indicates that the presence of sulfated polysaccharides is crucial in the liver protecting effect of macroalgae (Costa et ah, 2010). Other studies have evidenced the protective effect of seaweeds against liver toxicity induced by galactosamine in a rat model, concluding that this protecting effect is partly mediated by fucoidan, a sulfated polysaccharide from the brown seaweed Laminaria (Kawano et ah, 2007). [Pg.330]


See other pages where Protection liver is mentioned: [Pg.582]    [Pg.2019]    [Pg.2022]    [Pg.116]    [Pg.68]    [Pg.337]    [Pg.299]    [Pg.134]    [Pg.2022]    [Pg.36]    [Pg.23]    [Pg.32]    [Pg.25]    [Pg.48]    [Pg.849]    [Pg.1397]    [Pg.481]    [Pg.693]    [Pg.103]    [Pg.606]    [Pg.585]    [Pg.610]    [Pg.481]    [Pg.693]    [Pg.301]    [Pg.288]    [Pg.401]    [Pg.7]    [Pg.329]   
See also in sourсe #XX -- [ Pg.24 ]




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