Brambell receptor

Telleman, P, and R.P. Junghans, The role of the Brambell receptor (FcRB) in liver protection of endocytosed immunoglobulin G (IgG) from catabolism in hepatocytes rather than transport of IgG to bile. Immunology, 2000.100(2) 245-51. 

Junghans, R.P, Finally The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG. Immunol Res, 1997.16(1) 29-51. 

FcRn was originally known as the Brambell receptor, based on multiple studies conducted by F. W. Brambell involving maternal transmission of antibodies across placenta and neonatal intestine in rabbits [3,5,122,123], Transport was saturatable with increases in plasma IgG leading to reductions in plasma half-life (tm) according to the formula... 

FIGURE 41.2 Clearance of antibodies is dependent on concentration. At low concentrations, therapeutic proteins may exhibit concentration-dependent clearance, with the clearance decreasing as concentrations increase. For most biological agents that display this behavior, the clearance will decrease to a particular level (the nadir in the curve) and then remain constant. However, for antibodies, a second form of saturation can occur, where the Brambell receptors become saturated, resulting in an apparent increase in clearance as concentrations increase. 

For large proteins, transfer across cell membranes is limited due to size and hydro-philicity of the molecule. There is some evidence that Brambell receptors may play a... 

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