Enzymes do Function Without Water as a Bulk Solvent- Lessons from Extreme Halophiles

Enzymes do Function Without Water as a Bulk Solvent-Lessons from Extreme Halophiles 

In fact, halophilic enzymes have been shown to function in low salt environments, where the salt is replaced by a suitable organic solvent typically those that are kosmotropic. For example, an extracellular protease from H. halobium, which requires 4M NaCl for optimal function, is highly active in as little as 0.2 M NaCl in the presence of 40% (v/v) dimethylsulfoxide (DMSO) [10]. The behavior of salts 

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