Le antigen expression

The immunoconjugate of doxorubicin with a chimeric anti-Le -related, tumour-associated antigen expressed on most human carcinomas, was evaluated in phase I [132] and phase II [133] clinical trials. The phase II trial performed in patients with metastatic breast carcinoma showed low clinical response rates. These data together with tumour biopsy analysis suggest that the dose that could be safely administered was insufficient to maintain the intra-tu-... 

H. pylori P466 was also shown to have the ability to elaborate the cancer-associated sialyl Le antigen in its LPS. The sialyl Le was expressed simultaneously with Le and, in lesser amounts, the Le antigen. These Lewis blood-group termini were connected to the a core OS similar to that of the type strain. 

The pattern of expression of Le antigen is a striking example of the species differences that occur in the expression of carbohydrate differentiation antigens. SSEA-1... 

Many reports indicate that malignant cancer cells express carbohydrate antigens other than sLe and sLe antigens. These reports show a correlation between expression of particular cell surface carbohydrate antigens and poor prognosis in cancer patients (104,105). Examples of these are seen in Lewis B (Le ) and Lewis Y (Le ) antigens overexpressed by breast, lung, ovarian, and endometrial cancers (104,106-110). 

Khanna R, Busson P, Burrows SR, Raffoux C, Moss DJ, Nicholls JM, Cooper L (1998) Molecular characterization of antigen-processing function in nasopharyngeal carcinoma (NPC) evidence for efficient presentation of Epstein-Barr virus cytotoxic T-cell epitopes by NPC cells. Cancer Res 58 31(>-314 King NJ, Maxwell LE, Kesson AM (1989) Induction of class I major histocompatibility complex antigen expression by West Nile virus on y interferon-refractory early murine trophoblast cells. Proc Natl Acad Sci USA 86 911-915... 

S.D. Hoff, Y. Matsushita, D.M. Ota, K.R. Cleary, T. Yamori, S.-I. Hakomori and T. Irimura, Increased expression of sialyl-dimeric Le antigen in liver metastases of human colorectal carcinoma. Cancer Res, 49 (1989) 6883-6888. 

Adachi, M., Hayami, M., Kashiwagi, N., et al. (1988) Expression of Le antigen in human immunodeficiency virus-infected human T cell lines and in peripheral lymphocytes of patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC). J. Exp. Med. 167(2), 323-331. 

Kuhn JA, Wong JYC, Beatty BG, Esteban JM, Williams LE, Beatty JD. Interferon enhancement of carcinoembryonic antigen expression in human colon carcinoma xenografts. J Immunother 1992 11 257-266. 

Astic L., Le Pendu J., Mollicone R., Saucier D. and Oriol R. (1989). Cellular expression of H B antigens in the rat olfactory system during development. J Comp Neurol 289, 386-394. 

The presence of one antigenic determinant may reduce the extent of expression of another. Thus, in an A glycoprotein of a secretor, the expression of the H determinant is largely inhibited, and by using enzymes (30) which destroy A or B activity, H activity is greatly increased (3, 7). Also, gene interactions may occur as, for example, when the H and Le genes are both present, a new specificity termed Leb arises... 

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