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Gene interactions

Xu, J., et al., "Genomewide Screen and Identification of Gene-Gene Interactions for Asthma-Susceptibility Loci in Three U.S. Populations Collaborative Study of the Genetics of Asthma," Am.. Hum. Genet., 68, 1437-1446 (2001). [Pg.58]

Microarray is a technology used to study gene interactions and control of biochemical pathways. [Pg.50]

Nayernia K, Drabent B, Meinhardt A, Adham IM, Schwandt I, Muller C, Sancken U, Kleene KC, Engel W (2005) Triple knockouts reveal gene interactions affecting fertihty of male mice. Mol Reprod Dev... [Pg.108]

Xu, J. F., Meyers, D. A., Ober, C., et al. (2001) Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations collaborative study on the genetics of asthma. Am. J. Hum. Genet. 68, 1437-1446. [Pg.178]

Consequently, it is possible to draw on the basis of analysis of osteopetrotic models mentioned so far a scheme of genetic regulation of osteoclast formation, activation, and final function (Figure 3). Still relatively less is known how various intercepted genes interact with each other, in other words, how CSF-1 pathway interacts with RANKL pathway and with regulation of... [Pg.96]

Leonard G (1993) Synthetic enhancement in gene interaction a genetic tool come of age. Trends Genet 9 362-366... [Pg.135]

Hansen, T. F. and Wagner, G. P. 2001. Modeling genetic architecture A multilinear theory of gene interaction. Theorethical and Population Biology, 59 61-86. [Pg.285]

Possible gene-interactive alterations in 5-HT function and BDNF expression was recently evaluated in mice with a combined manipulation of the genes for 5-HTT and BDNF. Male but not female 5-FlTT -BDNF DKO mice showed further decreases in brain 5-HT concentrations as well as further increases in anxiety-like behavior and stress reactivity compared to 5-HTT -BDNF controls (Murphy et al. 2003). These findings support the notion of critical role of gene-gene interaction in brain plasticity related to anxiety and related disorders. [Pg.99]

Mm-phy DL, Uhl GR, Holmes A, Ren-Patterson R, Hall FS, Sora I, Detera-Wadleigh S, Lesch KP (2003) Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders. Genes Brain Behav 2 350-364 N ebigil CG, Hickel P, Messaddeq N, Vonesch JL, Douchet M P, Monassier L, Gyorgy K, Matz R, Andriantsitohaina R, Manivet P, Laimay JM, Maroteaux L (2001) Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structiue and function. Circulation 103 2973-2979... [Pg.109]

Kim, M. ]., and C. D. Berdanier. Nutrient-gene interactions determine mitochondrial function effect of dietary fat. FASEB J 1998 12(2) 243-248. [Pg.146]

Stansfield 1, Jones KM, Kushnirov VV, Dagkesamanskaya AR, Poznyakovski Al, Paushkin SV, Nierras CR, Cox BS, Ter-Avanesyan MD, Tuite ME (1995) The products of the SUP45 (eRFl) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae. EMBO J 14 4365 373 Stansfield 1, Eurwilaichitr L, Akhmaloka, Tuite ME (1996) Depletion in the levels of the release factor eRFl causes a reduction in the efficiency of translation termination in yeast. Mol Microbiol 20 1135-1143 Stansfield 1, Kushnirov VV, Jones KM, Tuite ME (1997) A conditional-lethal translation termination defect in a sup45 mutant of the yeast Saccharomyces cerevisiae. Fur J Biochem 245 557-563 Stark H (2002) Three-dimensional electron cryomicroscopy of ribosomes. Curr Protein Pept Sci 3 79-91... [Pg.28]

To summarize, knockouts have proved useful in determining the function of some genes. However, the complexity of gene interactions often leads to the absence of any phenotype, and multiple knockouts are required to tease apart the actual function of a gene or gene family. Moreover, certain genes are absolutely required during early development. Conditional knockout techniques have been developed in attempts to res-... [Pg.79]

Costea 1, Moghrabi A, Krajinovie M. The influence of cyclin D1 (CCNDl) 870 A>G polymorphism and CCNDl-thymidylate synthase (TS) gene-gene interaction on the outcome of childhood acute lymphoblastic leukaemia. Pharmacogenetics 2003 13 577-580. [Pg.310]

Higher predictive power than candidate gene approach taking consideration of gene-gene interactions in polygenic traits... [Pg.366]

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See also in sourсe #XX -- [ Pg.389 , Pg.390 ]



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