Antigen overexpression

Cancer antigen overexpressed in adenocarcinoma Intracellular adhesion molecule Primarily pancreatic... 

Many reports indicate that malignant cancer cells express carbohydrate antigens other than sLe and sLe antigens. These reports show a correlation between expression of particular cell surface carbohydrate antigens and poor prognosis in cancer patients (104,105). Examples of these are seen in Lewis B (Le ) and Lewis Y (Le ) antigens overexpressed by breast, lung, ovarian, and endometrial cancers (104,106-110). 

Pharmexa s Telovax is a telomerase peptide vaccine for the treatment of locally advanced or metastatic pancreatic cancer. Telomerase is a common tumour antigen overexpressed in most tumour types and, importantly, recent studies suggest that tumour stem cells are also telomerase positive [109]. As telomerase is important in the maintenance of telomeres and replicative immortality, it is expected that tumours cannot develop resistance to telomerase-based therapies. 

Ad460CEA Lung caacer/CEA CEA-EIA TATA box deleted in ElA Carcinoembryogenic antigen overexpression 90... 

Addison CL, Belperio JA, Burdick MD, Stricter RM. Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis. BMC Cancer 2004 4(1) 28. 

Yung, R. et al., Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice, J. Clin. Invest., 97, 2866, 1996. 

Only 20% to 33% of metastatic breast carcinomas robustly express HER2, and tumors that do not overexpress the protein are unlikely to benefit from treatment. Hence demonstration of clinical benefit in unselected breast cancer patients was a challenging task [24]. The need to keep patients on other chemotherapies added to the complexity of clinical trials. Nevertheless, the decision to first demonstrate overexpression of HER2 antigen levels as one of the key clinical trial inclusion criteria, reached in consultation with the FDA, allowed the investigators to demonstrate efficacy (Table 14.2). 

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