Human Herpes virus

Striebel, H.M., Birch-Hirschfeld, E., Egerer, R., Foldes-Papp, Z., Tilz, G.P., and Stelzner, A. (2004) Enhancing sensitivity of human herpes virus diagnosis with DNA microarrays using dendrimers. Exp. Mol. Pathol. 77, 89-97. 

IARC, Epstein-Barr virus and Kaposi s sarcoma herpesvirus/human herpes virus 8IARC Press, Lyon, France, 1997. 

Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against human herpes viruses. 

It is an acyclic guanosine analog which require triphosphorylation for activation prior to inhibition of viral DNA polymerase. It is active against cytomegalovirus (CMV), varicellazoster virus, Epstein-Barr virus and human herpes virus-8. It is almost 100 times more potent than acyclovir against CMV. 

Allergic reactions manifesting as fever, urticaria or other rashes, and arthralgia occur in 1-5% of patients taking antithyroid drugs. There has been a report of thiamazole-induced hypersensitivity syndrome associated with reactivation of human herpes virus 6 and cytomegalovirus (57). 

Hasegawa, K., Motsuchi, W., Tanaka, S., and Dosako, S. 1994. Inhibition with lactoferrin of in vitro infection with human herpes virus. Jpn. J. Med. Sci. Biol. 47, 73-85. 

Assaying inhibition of HIV infection can also be useful to determine the specificity of chemokines for particular receptors. For example vMIPII, a chemokine encoded by Human Herpes virus 8 (HHV8), was first shown to bind CCR3 by its ability to inhibit HIV infection of CCR3+ cells (38,39). 

Human herpes virus 8 (HHV-8) Activation of oncogenes and expression of a virally encoded VEGF receptor Flaitz and Hicks [63]... 

Fig. 3. The gplSO family of cytokines and receptors. Schematic representation of gpl30 and leukemia inhibitory factor receptor (LIFR) oriented in a cell membrane. Of the four-helix bundle gplSO cytokines, structural information currently exists for human interleukin 6 (IL-6) (green) (Somers et al, 1997), human herpes virus interleukin 6 (HlTV-8 IL-6) (purple) (Chow et al, 2001a), ciliary neurotrophic factor (CNTF) (orange) (McDonald et al., 1995), leukemia inhibitory factor (LIF) (blue) (Robinson et al, 1994), and oncostatin-M (OSM) (red) (Deller et al, 2000). Lower panel is a detailed list of gplSO cytokines and the associated receptors incorporated into the final signaling complex. (See Color Insert.)...

The most compelling evidence against a microbial etiology is the fact that no single infectious agent has been identified as the cause of MS. Many possible agents have been implicated, including mycoplasma, spirochetes, rabies virus, herpes simplex, canine distemper virus, coronavirus, human T-cell leukemia virus type I (HTLV-I), MS-associated retrovirus, measles, and most recently, human herpes virus type 6 (HHV-6) and Chlamydia pneumoniae However, to date, no causal relationship has been established. ... 

Swanborg RH, Whittum-Hudson JA, Hudson AP. Infectious agents and multiple sclerosis Are Chlamydia pneumoniae and human herpes virus six involved J Neuroimmunol 2003 136 1-8. 

Epidemiological evidence points to a connection between long-term inflammation and the development of cancer that is characterized by dysplasia, hyperplasia, and sometimes irreversible cancer transformations. Nearly 15% of worldwide cancer incidence in humans is associated with microbial infection (Kuper et al. 2002). Chronic infections, with human papilloma virus or with hepatitis B or C viruses in immunocompetent human hosts, can lead to cervical and hepatocellular carcinomas, respectively. Infection with the human herpes virus can produce Kaposi s sarcoma in the skin. Karposi s cancers are seen more often in the IDS-compromised AIDS patients. After protracted inflammation, Helicobacter pylori can cause stomach irrita-... 

PRIMARY EFFUSION LYMPHOMA " A neoplasm induced by human herpes virus 8 (Kaposi s sarcoma-associated... 

Patel RM, Goldblum JR, His ED. Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi s sarcoma. Mod Pathol. 2004 17 456-460. 

Pemphigus Herpes simplex virus, human herpes virus-8, Epstein-Barr virus, human immunodeficiency virus, cytomegalovirus... 

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