Isopropyl amine

The amines are a group of compounds with the general formula R-NHj, and all the common amines are hazardous. As a class the amines pose more than one hazard, being flammable, toxic, and, in some cases, corrosive. The amines are an analogous series of compounds and follow the naming pattern of the alkyl halides and the alcohols that is, the simplest amine is methyl amine, with the molecular formula of CH NHj. Methyl amine is a colorless gas with an ammonia-like odor and an ignition temperature of 806°F. It is a tissue irritant and toxic, and it is used as an intermediate in the manufacture of many chemicals. Ethyl amine is next in the series, followed by propyl amine, isopropyl amine, butyl amine and its isomers, and so on. 

Modification of the synthesis of the side chain by reaction of 73 with isopropyl amine rather than diethylamine gives eventually the haloamine, 94. Alkylation of the aminoquinoline (92)... 

Thionyl chloride Bromine Sodium hydride Isopropyl amine Hydrogen chloride... 

Peggion E, Cosani A, Mattucci AM, Scoffone E (1964) Polymerization of gamma-ethyl-L-glutamate-N-carboxyanhydride initiated by Di-N-butyl and Di-isopropyl amine. Biopolymers 2 69-78... 

A number of other types of chiral auxiliaries have been employed in enolate alkylation. Excellent results are obtained using amides of pseudoephedrine. Alkylation occurs anti to the a-oxybenzyl group.93 The reactions involve the Z-enolate and there is likely bridging between the two lithium cations, perhaps by di-(isopropyl)amine.94... 

The components of GB2 are methylphosphonic difluoride (DF) and a mixture of isopropyl alcohol and isopropyl amine (OPA). 

METHYL ETHYL SULPHIDE N-PROPYL AMINE ISOPROPYL AMINE TRIMETHYL AMINE MALEIC ANHYDRIDE VINYL ACETYLENE... 

White recently illustrated the use of fast supercritical fluid and EFLC for drug discovery and purification [46]. The optimized isocratic separations used to scale up to preparative-scale separations were often EFL mixtures. For example, Figure 9.13 shows the optimized conditions for the separation of a drug candidate included 30% methanol (with 0.2% isopropyl amine)/C02 on a Chiralcel OJ-H column at 5 mL/min [46]. His work also illustrates by using gradients that start in supercritical conditions and then move into EFL mixture conditions provides efficient and fast separations. 

FIGURE 9.13 Optimized ioscratic separation of the enantiomer pair for a drug candidate. Mobile phases 30% methanol containing 0.2% isopropyl amine/70% CO2 on a Chiralcel OJ-H column, flow rate 5 mL/min, outlet pressure 12.0 MPa and temperature 313 K. (Reprinted from C. White, J. Chromatogr. A, 1079 163 (2005). With permission.)... 

Now, IPA is used primarily as a coating and processing solvent in paints, electronics applications, synthetic resins, personal care products, and cosmetics. It is also used as a chemical intermediate for isopropyl esters, isopropyl amines, methyl isobutyl ketone, diisobutyl ketone, and hydrogen peroxide production.-... 

S. Furyt phoaphopodiohtoridate. A 1-L flask, protected from moisture by a calcium chloride tube. Is charged with 42 g (0.5 mol) of 2(5H)-furanone, 85 g (0.55 mol) of phosphoryl chloride and 100 iri. of methylene chloride. A solution of 65 g (0.5 mol) of ethyl d1 isopropyl amine In 60 mL of methylene chloride Is added dropwlse during 4 hr at ambient temperature (Note 9). The resulting mixture Is stirred overnight (12 hr), after which 6.5 g of the amine... 

Ethyl amine is next in the series, followed by propyl amine, isopropyl amine, butyl amine and its... 

The different behaviour of, e. g., di-isopropyl amine and n-hexyl amine now becomes explicable. The sterically unhindered n-hexyl amine mainly functions as a Lewis base which adds to the Lewis acid (the NCA) and initiates the simple amine-propagated polymerisation. On the other hand, the sterically hindered di-iso-propyl amine is inefficient as a Lewis base but, being a more powerful Bronsted base than n-hexyl amine, it initiates a rapid polymerisation resulting from the proton abstraction and the "activation of the monomer. This is seen in Fig. 7 (see also p. 19). 

It can be converted to a water-soluble, insensitive material, not susceptible to initiation, by treatment for 15 minutes at 87°, with 30 wts of a 15% soln of Na sulfide nonahydrate (Ref 1). Amm sulfide behaves similarly, but reacts much more slowly. These procedures involve reduction of the nitro groups to amino and other groups less energetic than nitro. TNT can be rapidly rendered non-expl by treatment with isopropyl-amine in a good solvent for TNT (eg, acetone or acetonitrile) (Ref 18). This system has been studied for destroying land mines (Refs 11 18). Destruction of the nitro groups in this system apparently occurs by the base-promoted redox reactions discussed under the reaction of TNT with bases. These chemical methods produce products of unknown toxicity, and are therefore suitable only for the treatment of small amounts of material on an occasional basis Other (limited-access) reports on the disposal of TNT are listed in the following Refs (Refs 4, 6,9,19,20 33)... 

The coexistence of NH3 is indispensable for selective benzene oxidation. Neither benzene oxidation nor combustion proceeded in the absence of NH3 (Table 2.5). Fe/ZSM-5 has been reported to be active and selective for phenol synthesis from benzene using N20 as an oxidant [97], but selective benzene oxidation did not proceed with N20 instead of 02. The addition of H20 to the system gave no positive effects on the catalytic performance, either. In addition, other amine compounds such as pyridine and isopropyl amine did not produce phenol. The phenol formation rate and selectivity increased with increasing NH3 pressure because the coexisting NH3 produces active Re clusters, as described below, and reached maximum conversion and selectivity at a partial pressure of NH3 of around 35—42kPa. 

SFE/derivatization of several chlorinated acid pesticides (those listed in EPA method 515.1) have been performed using conditions similar to those used for the bacterial phospholipids. The derivatized products from the SFE procedure for several representative organics are shown in Figure 6. As would be expected using the TMPA/methanol reagent, the carboxylic acids form the methyl esters (2,4-D and dicamba) while the phenols form the methyl ethers (pentachlorophenol). Esters of the carboxylic acids (e.g., the di-isopropyl amine ester of 2,4-D) also form the methyl esters. For ethers, two derivatized products resulted since the ether linkage could be cleaved on either side of the oxygen and methylated as shown by acifluorfen. 

A similar reaction was applied to an approach to norastemizole (148) and its analogues, which are of significant medicinal interest due to their wide range of biological activity. However, no reaction took place either with bulky amines such as isopropyl amine or with aromatic amines such as anisyl amine (Scheme 41) [94], An alternative method is a palladium-catalyzed amination of 149 based on the Buchwald method [95]. 

Propanolol hydrochloride is prepared from a-naphthol (1-naphthol) and epichlorohydrin. Subsequent treatment with isopropyl amine opens the epoxy ring to yield propanolol. Treatment with hydrochloric acid yields the hydrochloride. 

The reaction of perfluoro-2-methylpent-2-ene 641 with 2-amino-6-bromobenzothiazole 642 and with more nucleophilic isopropyl amine 643 afforded 2-azetines 644 (Equation 244) and 645 (Equation 245), respectively <2000RJ099>. 

---