Propanolol hydrochloride

Propranolol hydrochloride and promethazine hydrochloride increased the gel points and no straight line relationship existed, indicating that at higher concentrations these drugs enable the polymer to hydrate to a much larger extent than at lower concentrations. Promethazine forms micelles at concentrations. 5% w/v [9], which may be responsible for this behaviour. No critical micellar concentration is known for propanolol hydrochloride but from studies performed it is weakly surface active. The response of HPMC to these drugs may be associated with this surface activity. 

Fig. 2—Dissolution profiles of propanolol hydrochloride from K15M matrices into media, buffered to pH 6.0 containing various solutes.

The in vitro release data were treated with various kinetic models to assess the diffusion coefficient, the partition coefficient and the permeability coefficient. Using this information, the formulations evaluation were screened from their suitability to deliver propanolol hydrochloride as a topical dosage form. 

Propanolol hydrochloride is prepared from a-naphthol (1-naphthol) and epichlorohydrin. Subsequent treatment with isopropyl amine opens the epoxy ring to yield propanolol. Treatment with hydrochloric acid yields the hydrochloride. 

Sinchaipanid, N., Junyaprasert, V., and Mitrevej, A. (2004). Application of hot-melt coating for controlled release of propanolol hydrochloride pellets. Powder Technol. 141,203-209. 

Dabbagh MA, Ford JL, Rubinstein MH, et al. Release of propanolol hydrochloride from matrix tablets containing sodium... 

A NMR study on the formation of diastereoisomeric inclusion complexes between fluorinated amino acid derivatives and a-CD in 10% D2O solution shows that the chemical shifts of the D-amino acid derivatives included by a-CD are upheld from those of their L analogues [77]. The shift difference between the diastereoisomers formed with D and L enantiomers can be used for chiral analysis and optical purity determinations. For example, the interaction of -CD with propanolol hydrochloride produces diastereomeric pairs. The protons of the antipode give NMR signals which differ in chemical shifts in D2O solution at 400 MHz. The intensity of the resonance signals for each diastereoisomer has been used for optical purity determination. By adding racemate to pure (—) isomer, this technique is able to measure optical purity of propanolol hydrochloride in water down to the level of 1%. 

C16H22CINO2, Propanolol hydrochloride, 39B, 24 40B, 38 43B, 45 C16H36INO4, Tetrabutylammonium periodate, 43B, 49 Ci6H3 6Ni,S3, n-Tetrabutylammonium trisulfurtrinitride, 45B, 28 ClgHft2Br2N202f Decamethylenebis(trimethylanunonium) dibromide dihydrate, 30B, 34... 

Neah, S.H. Shinwari, M.K. Hellmuth, E.W. Melting point phase diagrams of free base and hydrochloride salts of bevantolol, pindolol and propanolol. Int. J. Pharm. 1993, 99, 303-310. 

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