Dimethyl isopropyl amine

Aminoxid Dimethyl-isopropyl-E16a, 409 (Amin-Oxidat.)... 

Massachusetts. 2,6-Dimethyl phenol and propanoyl chloride were obtained from Aldrich Chemical Company and used without further purification. Di isopropyl amine was distilled from calcium hydride prior to use. 2-Methylpropanal was distilled prior to use. 

AthyI-[ .phenyI-propylJ.amin 12, 1145. Dimethyl-[/J-phenyl isopropyl]-amin 12 1493. 

A reagent more reactive than tris(dimethylamino)arsine employed by Weingarten and White 39) was tetrakis(dimethylamino)titanium (145). With this compound it was possible to prepare N,N-dimethyl(l-isopropyl-2-methylpropcnyl)amine (147) from diisopropyl ketone. Weingarten and White 39) have suggested a possible mechanism for this reaction (see p. 88). If benzaldehyde 39,111), formaldehyde 111), or acetaldehyde 39) is used, the corresponding gem diamine or aminal (143) is formed. 

Of this product, 4.5 g in 30 cc of dry isopropyl alcohol are refluxed for 16 hours with 2.5 g of (3-chloroethyl dimethyl amine. The solution is cooled and filtered clear from the solid by-product. The solvent is removed under reduced pressure on the steam bath and the residue is washed with anhydrous ether. It is dissolved in ethyl acetate from which it crystallizes. It is the hydrochloride of (3-(dimethylamino)ethyl ester of 2-phenyl-2-( 1-hy-droxycyclopentyl) ethanoic acid, melting at 134° to 136°C. 

ETHYLENE GLYCOL ETHYL MERCAPTAN DIMETHYL SULPHIDE ETHYL AMINE DIMETHYL AMIDE MONOETHANOLAMINE ETHYLENEDIAMINE ACRYLONITRILE PROPADIENE METHYL ACETYLENE ACROLEIN ACRYLIC ACID VINYL FORMATE ALLYL CHLORIDE 1 2 3-TRICHLOROPROPANE PROPIONITRILE CYCLOPROPANE PROPYLENE 1 2-DICHLOROPROPANE ACETONE ALLYL ALCOHOL PROPIONALDEHYDE PROPYLENE OXIDE VINYL METHYL ETHER PROPIONIC ACID ETHYL FORMATE METHYL ACETATE PROPYL CHLORIDE ISOPROPYL CHLORIDE PROPANE... 

N,N-Diethyl-2- [methyl(cyclohexyloxy)phosphoryl]sulfanyl -N-methylethanaminium Iodide N,N-Diethyl-2-aminoethanol N,N-Diethyl-2-hydroxyethylamine N,N-Diethylethanolamine N,N-Diethyl-N-(/3-hydroxyethyl)amine N,N-Diisopropyl-(jS)-aminoethanol N,N-Diisopropyl-2-aminoethanol /V,/V-I)i isopropylamine N,N-Diisopropylaminoethanol /V,/V,-l)iisopropylcarbodiimide N,N-Diisopropylethanolamine N,N-Dimethyl-2-chloroethylamine N/N -DimethyM -bipyridinium /V,/V,-I)imethylhydrazine N,N-Dimethyl-N-(2-chloroethyl)amine /V,/Vd)irnethyl-/i-chloroethylamine /V,/V,-Methanetetrayl Biscyclohexanamine /V./V -Thiod i-2,1 -ethanediyl Bis(N-isopropyl)-2-propanamine N,a-Dimethylphenethylam ine... 

A recommended procedure for the preparation of highly hindered cyclic amines is illustrated by the following specific example. Reaction of Nl-isopropyl-2,2-dimethyl- 1,2-ethanediamine (1 eq.), acetone (2 eq.) and chloroform (1.2 eq.) under standard PTC conditions (CH2CI2, 50% NaOH, 2-5% BTAC, 5°C) gives a quantitative yield of a mixture of 1-isopropyl-3,3,5,5-tetramethyl-2-piperazinone and 4-isopropyl-3,3,6,6-tetramethyl-2-piperazinone in the ratio 73 27. More detailed examination of the reaction showed that careful control of the amount of chloroform used was essential, otherwise secondary reactions occurred. The type of secondary reaction which can occur is illustrated by the quantitative transformation of 2,2,6,6-tetramethyl-4-... 

Others 1,4-dioxane, 1,3,5-trioxane, terahydrofuran, 2-butyl tetrahydrofuran, N,N-dimethylformamide, N,N-dimethylacetamide, epsilon-caprolactam, benzothiazole, biphenyl, pyrazine, 2-butanone oxime, l-methyl-2-pyrrolidone, N,N-dimethyl-aniline, N,N-dimethyl-p-toluidine, l-methyl-7-isopropyl phenanthrene, dibenzyl-amine, hexamethylenetetramine, squalene, 2-ethylanthraquinone... 

Dimethyl-1-isopropyl- X/2, 76 (Imin + NH2C1) E16c, 683 (Oxim 4 Amin)... 

Chlor-1,2-dimethyl-propyliden)-isopropyl- El4b, 243 (Keton + Amin)... 

Thietan 3-Diethylamin-2,2-dimethyl-4-isopropyl- -1,1-dioxid E21e, 5074 (R2C =S02 + En —amin)... 

C6H13Br 2-bromo-2,3-dimethyl butane 594-52-5 406.15 34.383 1,2 8751 C6H13N N-isopropyl-2-propen-1-amine 35000-22-7 369.65 31.515 1.2... 

Planar chiral compounds should also be accessible from the chiral pool. An example (with limited stereoselectivity) of such an approach is the formation of a ferrocene derivative from a -pinene-derived cyclopentadiene (see Sect. 4.3.1.3 [81]). A Cj-symmetric binuclear compound (although not strictly from the chiral pool, but obtained by resolution) has also been mentioned [86]. Another possibility should be to use the central chiral tertiary amines derived from menthone or pinene (see Sect. 4.3.1.3 [75, 76]) as starting materials for the lithiation reaction. In these compounds, the methyl group at the chiral carbon of iV,iV-dimethyl-l-ferrocenyl-ethylamine is replaced by bulky terpene moieties, e.g., the menthane system (Fig. 4-2 le). It was expected that the increase in steric bulk would also increase the enantioselectivity over the 96 4 ratio, as indicated by the results with the isopropyl substituent [118]. However, the opposite was observed almost all selectivity was lost, and lithiation also occurred in the position 3 and in the other ring [134]. Obviously, there exists a limit in bulkiness, where blocking of the 2-position prevents the chelate stabilization of the lithium by the lone pair of the nitrogen. 

Pyrazines have been prepared by heating 1,2-dicarbonyl compounds with a-amino acids. Thus Rizzi (308) observed that under the conditions of the Strecker degradation, equimolar amounts of DL-valine (44) and butane-2,3-dione in refluxing bis(2-methoxyethyl) ether, diglyme, gave isobutyraldehyde, tetra-methylpyrazine (9%), and a mixture of cis- and trans-2-isopropyl-4,5-dimethyl-3-oxazoline (4%). He proposed a reductive amination mechanism in which butane-23-dione was converted to 2-aminobutan-3-one which underwent self-condensation to the pyrazine. Tetramethylpyrazine was also prepared when the same reactants were heated in dimethylformamide at 123° for 5 hours (and other pyrazines prepared similarly) (308a). 

DECANAL DIMETHYL ACETAL (112-30-1) Combustible liquid (flash point 180°F/ 82°C oc). Reacts, possibly violently, with oxidizers, acetaldehyde, alkalineearth, alkali metals, strong acids, ammonium persulfate, strong caustics, aliphatic amines, benzoyl peroxide, boranes, bromine dioxide, chromic acid, chromium trioxide, dialkylzincs, dichlorine oxide, ethylene oxide, hypochlorous acid, isocyanates, isopropyl chlorocarbonate, lithium tetrahydroaluminate, nitric acid, nitrogen dioxide, pentafluoroguanidine, perchlorates, peroxides, permanganates, phosphorus pentasulfide, sulfuric acid, tangerine oil, triethylaluminum, triisobutylaluminum. 

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