Autocrine regulation

Sabharwal, P, Varma, S., and Malarkey, W.B., Human thymocytes secrete luteinizing hormone An autocrine regulator of T-cell proliferation, Biochem. Biophys. Res. Com., 187, 1187, 1992. 

The humoral factors include numerous cytokines and growth factors, which act as classical endocrine, paracrine or autocrine regulators. Developing cells are sensitive to a range of such factors at all times during their maturation and, in the case of white blood cells, during their existence within the circulation. To ensure responsiveness during their development, cells must express on their surface a variety of receptors at different times. 

Figure 5.8. Several cells secreting IL-6 also display IL-6 receptors on their surface, thus facilitating autocrine regulation by this interleukin. In the case of fibroblasts and endothelial cells, this regulation appears negative (inhibitory to cell growth). In the case of plasmacytoma cells, however, the autocrine loop is positive, with IL-1 stimulating further growth...

Piepkorn, M., Pittelkow, M.R., and Cook, P.W., Autocrine regulation of keratinocytes the emerging role of heparin-binding, epidermal growth factor-related growth factors, / Invest. Dermatol., 111, 715, 1998. 

A5. Angelloz-Nicoud, P., and Binoux, M., Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3). Endocrinology 136, 5485-5492 (1995). 

Van Wagoner NJ, Oh JW, Repovic P, Benveniste EN (1999) Inter-leukin-6 (IL-6) production by astrocytes Autocrine regulation by IL-6 and the soluble IL-6 receptor. J Neurosci 19 5236-5244. 

Coleman D, Ruef C. Interleukin 6 an autocrine regulator of mesangial cell growth. Kidney Int 1992 41 604-611. 

The biological actions of TNFs are concentration dependent. At low concentrations (approximately 1X lO mol/L), they act locally as paracrine and autocrine regulators of immunoinflammation—being rapidly released or secreted at sites of injury or infection. TNFa primes both neutrophils... 

Van Voorhis, B.J., Dunn, M.S., Snyder, G.D., and Weiner, C.P. (1994). Nitric oxide An autocrine regulator of hutium granulosa-luteal cell steroidogenesis. Endocrinology 735 1799-1806. 

Autocrine regulation of cell proliferation and secretion of insulin-like growth factor I (IGF-I) in osteoblastic cell line MC3T3-E1]... 

The eicosanoids are a diverse group of extremely powerful hormonelike molecules produced in most mammalian tissues. They mediate a wide variety of physiological processes. Examples include smooth muscle contraction, inflammation, pain perception, and blood flow regulation. Eicosanoids are also implicated in several diseases such as myocardial infarct and rheumatoid arthritis. Because they are generally active within the cell in which they are produced, the eicosanoids are called autocrine regulators instead of hormones. Most eicosanoids are derived from arachidonic acid (20 4A5-81114), which is also called 5,8,11,14-eicosatetraenoic acid. (Arachidonic acid is synthesized from linoleic acid by adding a three-carbon unit followed by decarboxylation and desaturation.)... 

Krsmanovic, L.Z., S.S. Stojilkovic, L.M. Mertz, M. Tomic K.J. Catt. 1993. Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic nemons. Proc. NatL Acad. ScL USA 90 3908-12. 

Adenylate cyclase activating polypeptide 1 (pituitary), also known as ADCYAPl, is a human gene. They are also considered a type of paracrine and autocrine regulators of enteroendocrine cells (neuroendocrine cells) [12],... 

Boyan, B.D. and Schwartz, Z. 2009. 1,25-Dihydroxy vitamin D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60-activated matrix vesicle matrix metaUoproteinases. Cells Tissues Organs 189(1-4) 70-4. 

Augustin-Voss, H.G. and Pauli, B.U., Quantitative analysis of autocrine-regulated, matrix-induced, and tumor cell-stimulated endothelial cell migration using a sihcon template compartmentaliza-... 

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