IGF binding proteins

Kanagaraj, P, MR Vijayababu, B Ravisankar, J Anbalagan, MM Aruldhas, and J Aranakaran. 2007. Effect of lycopene on insulin-like growth factor-1, IGF binding protein-3, and IGF type-1 receptor in prostate cancer cells. 7 Cancer Res Clin Oncol 133 351-359. 

Li, L, H Ya, F Schumacher, G Casey, and JS Witte. 2003. Relations of serum insulin-like growth factor-1-(IGF-1) and IGF binding protein-3 to risk of prostate cancer(United States). Cancer Causes Control 14 721-726. 

Kleinman D, Karas M, Danilenko M (1996) Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction of IGF binding proteins. Endocrinology 137 1089-1095... 

The liver represents the major site of synthesis of the IGFs, from where they enter the blood stream, thereby acting in a classical endocrine fashion. A wide variety of body cells express IGF receptors, of which there are two types. Furthermore, IGFs are also synthesized in smaller quantities at numerous sites in the body and function in an autocrine or paracrine manner at these specific locations. IGF activity is also modulated by a family of IGF binding proteins (IGFBPs), of which there are at least six. 

Table 7.5. The range of human IGF binding proteins (IGF BPs or BPs ), and an indication of their relative affinities for ligand. AA indicates a higher affinity than...

Mecasermin Recombinant form of IGF-1 that stimulates IGF-1 receptors Restores normal growth and metabolic IGF-1 effects in individuals with IGF-1 deficiency Replacement in IGF-1 deficiency that is not responsive to exogenous GH SC injection 2 x/d also contains recombinant human IGF-binding protein-3, which prolongs the half-life of the rIGF-1 Toxicity Hypoglycemia, intracranial hypertension, increased liver enzymes... 

IGF-binding proteins. Protein binding of IGF-1 serves to increase its half-life. Thorne et al. [109] demonstrated that in rats, nasally administered IGF-1 was rapidly transported into the brain. IGF-1 uptake into the brain appeared to follow two routes, through olfactory nerve tracts and through trigeminal associated extracellular pathways. The net effect of nasal IGF-1 administration in rats was to rapidly elicit biological effects at several sites in the brain. 

Matsui H, Takahashi T. Mouse testicular leydig cells express klk21, a tissue kallikrein that cleaves fibronectin and igf-binding protein-3. Endocrinology 2001 142 4918-4929. 

Tolins JP, Raij L (1990) Comparison of converting enzyme inhibitor and calcium channel blocker in hypertensive glomerular injury. Hypertension 10 452-461 Tonshoff B, Powell DR, Zhao D et al. (1997) Decreased hepatic insulin-like growth factor (IGF)-I and increased IGF binding protein-1 and -2 gene expression in experimental uremia. Endocrinology 138 938-946... 

A5. Angelloz-Nicoud, P., and Binoux, M., Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3). Endocrinology 136, 5485-5492 (1995). 

A6. AngellozrNicoud, P., Harel, L., and Binoux, M., Recombinant insulin-like growth factor (IGF) binding protein-3 stimulates prostate carcinoma cell proliferation via an IGF-dependent mechanism. Role of serine proteases. Growth Regul. 6, 130-136 (1996). 

B4. Benbassat, C. A., Maki, K. C., and Unterman, T. G., Circulating levels of insulin-like growth factor (IGF) binding protein-1 and -3 in aging men Relationships to insulin, glucose, IGF, and dehydroepiandrosterone sulfate levels and anthropometric measures. J. Clin. Endocrinol. Metab. 82, 1484-1491 (1997). 

F6. Figueroa, J. A., Lee, A. V., Jackson, J. G., and Yee, D., Proliferation of cultured human prostate cells is inhibited by insulin-like growth factor (IGF) binding protein-1 Evidence for an IGF-II... 

Proinsulin, Insulin, Insulin-like Growth Factors (IGF), IGF-Binding Proteins,... 

The growth hormone/insulin-like growth factor (IGF) axis plays a role in ovarian responsiveness. The IGF system comprises of IGF-I and -II and their binding-proteins, IGF-binding proteins (BP)-l to -6 (G3). 

Oosterhuis, G. J. E., Vermes, I., Lambalk, C. B., Michgelsen, H. W. B., and Schoemaker, J., Insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in fluid from human stimulated follicles. Hum. Reprod. 13,285-289 (1998). 

Baxter RC. Insulin-like growth factor (IGF) binding proteins The role of serum IGFBPs in regulating IGF availability. Acta Paediatr Scand Suppl 1991 372 107-14. 

Nyomba BL, Berard L, Murphy LJ. Free insulinlike growth factor I (IGF-I) in healthy subjects Relationship with IGF-binding proteins and insulin sensitivity. J Clin Endocrinol Me tab 1997 82 2177-81. 

Cheetham TD, Holly JM, Baxter RC, Meadows K, Jones J, Taylor AM et al. The effects of recombinant human IGF-I administration on concentrations of acid labile subunit, IGF binding protein-3, IGF-I, IGF-II and proteolysis of IGF binding protein-3 in adolescents with insulin-dependent diabetes mellitus. J Endocrinol 1998 157 81-7. 

Blum W, Ranke W, Bierich RR. A specific radioimmunoassay for insulin-hke growth factor II The interference of IGF binding proteins can be blocked by excess IGF-L Acta Endocrinol 1988 18 374-80. 

R245 R. C. Baxter, Insulin-Like Growth Factor (IGF) - Binding Proteins Interactions with IGFs and Intrinsic Bioactivities , Am. J. Physiol., 2000, 278, E967... 

Burgos R, Mateo C, Canton A, Hernandez C, Mesa J, et al. 2000. Vitreous levels of IGF-I, IGF binding protein 1, and IGF binding protein 3 in proliferative diabetic retinopathy A case-control study. Diabetes Care 23 80-83. 

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