Insulin degrading enzymes

The ECE isoforms show different subcellular distributions and enzymatic characteristics (Table 2). ECE-la and ECE-lc are mainly expressed at the cell surface, whereas ECE-lb, ECE-Id and ECE-2 are expressed intracellularly. Plasma membrane-bound ECE cleaves big-ET-1 circulating in the blood, whereas intracellular ECE isoforms are involved in the generation of mature endothelins. In addition, ECEs (as well as NEP and the insulin-degrading enzyme) contribute to the degradation of amyloid (3 (A 3) peptide. 

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Keywords Amyloid precursor protein Apolipoprotein E p-amyloid peptide Beta-amyloid precursor protein converting enzyme Insulin degrading enzyme Neurofibrillary tangle Oxidative damage Presenilin-1... 

Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Ros-ner MR, Selkoe DJ (2000) Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci 20 1657-1665. 

Glycerol 3 phosphate dehydrogenase 3-Hydroxybutyrate dehydrogenase Insulysin (insulin degrading enzyme) Isocitrate dehydrogenase Lactate dehydrogenase Leucine aminopeptidase Lipase... 

Insulin-degrading enzyme inhibitors Peptide hydroxamate... 

Abdul-Hay SO, Lane AL, Caulfield TR, Claussin C, Bertrand J, Masson A et al (2013) Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. J Med Chem 56 2246-2255... 

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