Genetic Systems

The biota of long-distance dispersal. IV. Genetic systems in the flora of oceanic... 

Cook, S. 1962. Genetic system, variation and adaptation in Eschscholzia californica. Evolution 16 278-299. 

Monsanto/1996 Oilseed rape Plant Genetic Systems/1995 Oilseed rape (Canola)... 

The nonnucleoside reverse transcriptase inhibitors (NNRTIs), used in the treatment of AIDS, provide interesting examples of clinically relevant noncompetitive inhibitors. The causative agent of AIDS, HIV, belongs to a virus family that relies on an RNA-based genetic system. Replication of the vims requires reverse transcription of the viral genomic RNA into DNA, which is then incorporated into the genome of the infected host cell. Reverse transcription is catalyzed by a virally encoded nucleic acid polymerase, known as reverse transcriptase (RT). This enzyme is critical for viral replication inhibition of HIV RT is therefore an effective mechanism for abrogating infection in patients. 

Fields, S., and Song, O. (1989). A novel genetic system to detect protein-protein interactions. Nature 340, 245-246. 

Darlington CD 1939 The evolution of genetic systems. Basic Books, New York... 

The interaction of soybean cyst nematode (SCN) with soybean (Glycine max) has been extensively studied in the United States. This system has been used as a model to dissect the genetics of nematode parasitism, mainly due to the tractability of classical genetic manipulation of the nematode. The remainder of this brief review will focus on the SCN side of the interaction with its host and the progress that has been made in unravelling the complex genetic systems controlling parasitic behaviour. 

Volume 204. Bacterial Genetic Systems Edited by Jeffrey H. Miller... 

Fields S, Song O. A novel genetic system to detect protein-protein interactions. 

I would like to describe our investigations, performed in collaboration with Jeffrey Miller. To begin, I will briefly outline the genetic system developed by Miller which permits a rapid, rigorous determination of the position and kinds of mutants induced in a particular gene by DNA damaging agents. 

We have applied the genetic system for analyzing lacl nonsense mutants to the investigation of the mutagenic specificity of benzo-... 

Molecular control of gene escape the use of specific genetic systems to prevent transgene escape into environment. 

Some of the materials and techniques used in molecular biology may attract royalties if used for commercial purposes. Vectors, host strains and off-the-shelf DNA manipulation methods are usually readily available for modest licence fees for research purposes, but additional licences would need to be sought (and fees paid) if these systems were used in a commercial process. Where commercial exploitation is planned, the researchers should be prepared to switch to royalty-free genetic systems and avoid the use of costly and potentially toxic materials, such as artificial inducers or substrates, as gene expression regulators. 

Genetic systems for direct measurement are still under development. 

Tikhonovich lA et al. Integration of plant and microbial genetic systems in symbiosis, Uspek Sovrem Biol 125 227—238, 2005. 

Genetic Systems Corporation, 3005 1st Avenue, Seattle, WA 98121 Chemical Engineering Department, Center for Bioengineering, FLr-20, University of Washington, Seattle, WA 98195... 

Almaden Research Center, IBM, 22,57 Carnegie-Mellon University, 129 Centre d Etudes Nucl aires de Grenoble, 115 Gen Corporation, 22 Genetic Systems Corporation, 245,255 Institut Charles Sadron, 33 Institut fur Makromolekulare... 

J. Gao, H. Liu, and E. T. Kool, Assembly of the complete eight-base artificial genetic helix, xDNA, and its interaction with the natural genetic system, Angew. Chem. Int. Ed., 44 (2005) 3118-3122. 

Marc Claeyssens thanks the NFWO (Belgium) and NATO for grants. Herman van Tilbeurgh s present address is Plant Genetic Systems, Plateaustraat, 9000 Gent, Belgium. 

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