Amyloid-beta protein precursor

Lu, D. C. et al. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat. Medicine 2000, 6, 397—404. 

Yoshikai, S., Sasaki, H., Doh-ura, K., Furuya, H., Sakaki, Y. (1990) Genomic organization of the human amyloid beta-protein precursor gene. Gene, 87, 257-263. 

Tanzi, R.E., Vania, G., Romano, D.M., et al. (1992) Assessment of amyloid beta-protein precursor protein gene mutations in a large set of familial and sporadic Alzheimer disease cases. Am. J. Hum. Genet., 51, 273-282. 

Suzuki, N., Cheung, T.T., Cai, X.-D., et al. (1994) An increased percentage of long amyloid beta protein secreted by fanrUial amyloid beta protein precursor (beta-APP-717) mutants. Science, 264,1336-1340. 

Golden RN, Morris JE, Sack DA Combined lithium-tricyclic treatment of obsessive-compulsive disorder. Biol Psychiatry 23 181-185, 1988 Goldenberg G, Lang W, Podreka 1, et al Are cognitive deficits in Parkinson s disease caused by frontal lobe dysfunction Journal of Psychophysiology 4 137-144, 1990 Goldgaber D, Harris HW, Hla T Interleukin-1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A 86 7606-7610, 1989... 

Van Nostrand WE, Wagner SL, et al. Decreased levels of soluble amyloid beta protein precursor in cerebrospinal fluid of live Alzheimer disease patients. Proc Natl Acad Sci USA 1992 89(7)2551-2555. 

Mucke L, MasUah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Fotss-Petter S, Pietropaolo M, Mallory M, Abraham CR (1994) Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Res 666 151-167 Nacmias B, Piccini C, Bagnoli S, Tedde A, Cellini E, Bracco L, Sorbi S (2004) Brain-derived neurotrophic factor, apolipoprotein E genetic variants and cognitive performance in Alzheimer s disease. Neurosci Lett 367 379-383... 

Selkoe DJ (1994) Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer s disease. Annu Rev Cell Biol 10 373 03. 

Imaizumi, K., Iwata, H., Yoshida, S., Sun, G., Okumura, N. and Shiosaka, S. (1993) Coexistence of amyloid beta-protein precursor and basic fibroblast growth factor in single cells of the rat parietal cortex, hippocampus and basal magnocellular nucleus, y. Chem. Neuroanat. 6 159-165. 

Rockenstein, E., McConlogue, L., Tan, H., Power, M., Masliah, E., and Mucke, L. (1995) Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer s disease. Biol. Chem. 270, 28257-28267. 

Aho L, Pikkarainen M, Hiltunen M et al (2010) Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain. J Alzheimers Dis 20 1015-1028... 

Van Broeckhoven, C., et al.. Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science, 1990.248(4959) p. 1120-2. 

Wasco, W., et al. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer s associated amyloid beta protein precursor. Nat Genet, 1993. 5(1) p. 95-100. 

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