Double vision

USP (Oncovin) vindesine sulfate [59917-39 ] C43H55N5O7 -H2S0 852.01 (50) chil-dren lymphocytic leukemia Hodgkin s disease non-Hodg-kin s lymphomas Wilm s tumor neuroblastoma rhabdomyosarcoma, investigational dmg (paresthesias, foot drop, double vision, etc) constipation ileus alopecia leu-kopenia (occasional) ... 

Administration of trimethadione (Tridione) may result in hematologic changes, such as pancytopenia (decrease in all the cellular components of the blood), leukopenia, aplastic anemia, and thrombocytopenia Also reported are various types of skin rashes, diplopia (double vision), vomiting, changes in blood pressure, CNS depression, photosensitivity, and fatal nephrosis. Because these dm have been associated with serious adverse reactions and fetal malformations, they should be used only when other less toxic dm are not effective in controlling seizures. The oxazolidinediones may precipitate a tonic-clonic seizure... 

Patients with vertigo and double vision are likely to have posterior circulation involvement. 

Telithromycin 800 mg once daily x 5 days Not available Improved pneumococcal coverage over macrolides can cause blurred or double vision and difficulty focusing cost and other side effects similar to clarithromycin-azithromycin... 

Primary axillary hyperhidrosis Adverse events (in at least 3% of patients) included injection site pain and hemorrhage, nonaxillary sweating, infection, pharyngitis, flu syndrome, headache, fever, neck or back pain, pruritus, and anxiety. Blepharospasm The most frequently reported treatment-related adverse reactions were ptosis (20.8%), superficial punctate keratitis (6.3%), and eye dryness (6.3%). Strabismus Extraocular muscles adjacent to the injection site can be affected, causing ptosis, vertical deviation, spatial disorientation, double vision, or past-pointing, especially with higher doses of botulinum toxin type A. 

Dizziness, drowsiness, double vision, headache, ataxia, nausea, diarrhea, vomiting,... 

Toxic phenytoin blood concentration of 25 mcg/ml may produce ataxia, characterized by muscular incoordination, nystagmus or rhythmic oscillation of eyes, and double vision. As level increases, extreme lethargy to comatose states occurs. 

Lamotrigine is well tolerated and is not associated with hepatotox-icity, weight gain, or significant sedation. Common early side effects include headache, dizziness, gastrointestinal distress, and blurred or double vision. The most serious potential side effect is rash (described in the following subsection). 

Carbamazepine Dose-related double vision, vertigo, gastrointestinal disturbance Idiosyncratic agranulocytosis, Stevens-Johnson syndrome, aplastic anemia... 

Adverse effects include blurred or double vision, dizziness, drowsiness, abdominal cramps, confusion, headache, hiccups, anaemia etc. 

CN S manifestations are excitatory and / or depressant and may be characterised by light-headedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensation of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression. 

A 64-year-old man with giant cell arteritis was given prednisolone 60 mg/day. Within 5 days he developed double vision and agitation and became drowsy and confused. A cranial MRI scan showed recent cerebral lesions and a Doppler scan showed high-resistant blood flow in both vertebral arteries. He had an episode of complete loss of vision and was given dexamethasone... 

This chapter deals with botulinum toxin type A (BOTOX) in the treatment of strabismus, blepharospasm, and related disorders. Botulinum toxin type A (BOTOX) has been used to treat strabismus, blepharospasm, Meige s syndrome, and spasmodic torticollis. By preventing acetylcholine release at me neuromuscular junction, botulinum toxin A usually causes a temporary paralysis of the locally injected muscles. The variability in duration of paralysis may be related to me rate of developing antibodies to me toxin, upregulation of nicotinic cholinergic postsynaptic receptors, and aberrant regeneration of motor nerve fibers at me neuromuscular junction. Complications related to this toxin include double vision (diplopia) and lid droop (ptosis). 

Hypoglycemia is a primary complication of insulin therapy and may result from either an excess of insulin or a lack of glucose, or both. Severe hypoglycemia may cause headache, confusion, double vision, drowsiness, and convulsions. The treatment of this hypoglycemia may include the administration of glucose or glucagon. 

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