Inhibitors phenothiazine

Ethylene Oxide, H2COCH2 Acetylides, Fe, Sn, Organic Acids, Amines, Al oxides OH- Ions Ammonia, H, HCN > Ambient > 30 Inhibitor—Phenothiazine, Keep temp below 30° avoid active catalysts. No sparks Activation >445 =19.7 <445°=36.4 429 Use of catalysts— Fe, Sn, Organic Acids and Ammonia... 

MAO inhibitors, phenothiazines, propafenone, quinidine, quinolones (ciprofloxacin), thioamines, and thyroid hormones. 

The advantage of using free radical inhibitors to facilitate the copolymerization of a bisbenzocyclobutene with a bismaleimide was first noted in a patent to Bartmann [78]. Subsequent to this, Corley in a series of patents described some detailed experiments on the copolymerization of bisbenzocyclobutenes with bismaleimides both with and without the addition of a free radical inhibitor [33, 34]. The structures of the bisbenzocyclobutenes used in this study are shown in Fig. 33. The bismaleimide component that was used was a mixture of three different bismaleimides in the molar ratio shown in Fig. 34. The individual bisbenzocyclobutenes were blended at elevated temperature with varying amounts of the bismaleimide composition. In some of the experiments, the free radical inhibitor phenothiazine was added at a 0.5 mole % level. The various monomer mixtures were then copolymerized using one of the cure schedules described in Table 14. The copolymers were then physically characterized using a variety of techniques. Table 14 shows the results obtained from copolymers... 

Acetylcholinesterase inhibitors Acetylcholinesterase inhibitors Phenothiazine antipsychotics Antagonize acetylcholine Avoid use of anticholinergics when... 

Clinically important, potentially hazardous interactions with CNS depressants, MAO inhibitors, phenothiazines, tranquilizers... 

NORTRIPTYLINE, see Tricyclic antidepressants OXAZEPAM, see Benzodiazepines PERPHENAZINE, see Phenothiazines, piperazine PHENELZINE, see MAO inhibitors PHENOTHIAZINES, ALIPHATIC (chlorpromazine, triflupromazine)... 

Monoamine oxidase inhibitors, phenothiazine and tricyclic antidepressants potentiate the cardiac stimulatory effects of epinephrine. AH should be stopped 1 to 2 weeks before any kind of surgery involving epinephrine. Propranolol has been reported to cause malignant hypertension and reflux bradycardia when combined with epinephrine. The possibility of this rare complication should be weighed against the necessity for using this drug in consultation with the patient s primary care physician. 

The Hofmann elimination route, of which many versions exist, can be carried out at much lower temperatures in conventional equipment. The PX is generated by a 1,6-Hofmaim elimination of amine from a quaternary ammonium hydroxide in the presence of a base. This route gives yields of 17—19%. Undesired polymeric products can be as high as 80% of the product. In the presence of a polymerization inhibitor, such as phenothiazine, DPXN yields can be increased to 50%. 

Polymerizations using trialkylborons are not slowed as mueh as is normal by the presenee of eonventional inhibitors sueh as p-phenylenediamine, hydro-quinone, benzoquinone, phenothiazine or others [74]. This has been attributed to... 

Some other inhibitors from the patent literature include hydroquinone [129], ionoP [130], and quinone [131]. Other inhibitors used to stabilize MMA include butylated hydroxy toluene (BHT), phenothiazine, methylene blue, hydroxy-diphenylamine and di-/jc/<3-napthol [132]. Several good reviews of inhibition and inhibitors have been written [133-136]. The mechanisms of inhibition are subtle and complicated. For example, it has been reported that highly purified benzo-quinone acts as a retarder rather than an inhibitor [137]. It has been proposed... 

Chemical Reactivity - Reactivity with Water No reaction Reactivity with Common Materials No reaction Stability During Transport Normally unstable but will be detonate Neutralizing Agents for Acids and Caustics Wash with water, rinse with sodium bicarbonate solution Polymerization May occur in contact with acids, iron salts, or at elevated temperatures and release high energy rapidly may cause explosion under confinement Inhibitor of Polymerization Monomethyl ether of hydroquinone 180-200 ppm phenothiazine (for tech, grades) 1000 ppm hydroquinone (0.1 %) methylene blue (0.5... 

Common inhibitors include stable radicals (Section 5.3.1), oxygen (5.3.2), certain monomers (5.3.3), phenols (5.3.4), quinones (5.3.5), phenothiazine (5.3.6), nitro and nitroso-compounds (5.3.7) and certain transition metal salts (5.3.8). Some inhibition constants (kjkp) are provided in Table 5.6. Absolute rate constants (kj) for the reactions of these species with simple carbon-centered radicals arc summarized in Tabic 5.7. 

A container of acryloyl chloride containing 0.05% of phenothiazine used as an inhibitor, was expos to very unfavourable climatic conditions that brought it to a temperature of 50°C for two days. After this time, it polymerised violently, shattering its container and forming a voluminous foam. Yet the container label mentioned that it could not be stored at temperatures greater than 4°C. 

The phenothiazines, chlorpromazine and promethazine, have been described as inhibitors of CCU-induced lipid peroxidation at relatively high concentrations in rat liver microsomes (Slater, 1968). Structural modifications of chlorpromazine were undertaken to try to increase antioxidant activity and maintain molecular lipophilicity. The 2-N-N-dimethyl ethanamine methanesulphonate-substituted phenothiazine (3) was found to be a potent inhibitor of iron-dependent lipid peroxidation. It was also found to block Cu -catalysed oxidation of LDL more effectively than probucol and to protect primary cultures of rat hippocampal neurons against hydrogen peroxide-induced toxicity in vitro (Yu et al., 1992). 

Tricyclic antidepressants Monoamine oxidase inhibitors Selective serotonin reuptake inhibitors Antipsychotics Phenothiazines Risperidone Lithium... 

Gastrointestinal motility promotors Anti emetics H2 antagonists Phenothiazines 5-ITT inhibitors... 

Chlorpromazine is an aliphatic phenothiazine antipsychotic used in schizophrenia and which may exacerbate parkinsonism. Co-careldopa is a combination of levodopa and the peripheral dopa-decarboxylase inhibitor, carbidopa. Co-careldopa, amantadine, entacapone and bromocriptine are all indicated in the management of parkinsonism. 

Drugs that may affect repaglinide include CYP 450 inhibitors (eg, clarithromycin, erythromycin, ketoconazole, miconazole), CYP 450 inducers (eg, barbiturates, carbamazepine, rifampin), beta blockers, calcium channel blockers, chloramphenicol, corticosteroids, coumarins, estrogens, gemfibrozil, isoniazid, itraconazole, levonorgestrel and ethinyl estradiol, MAOIs, nicotinic acid, NSAIDs, oral contraceptives, phenothiazines, phenytoin, probenecid, salicylates, simvastatin, sulfonamides, sympathomimetics, thiazides and other diuretics, and thyroid products. 

Drugs that may interact with nitrates include alcohol, alteplase, aspirin, beta-blockers, calcium channel blockers, dihydroergotamine, heparin, nondepolarizing muscle relaxants, phenothiazines, phosphodiesterase inhibitors (eg, sildenafil, tadalafil, vardenafil), and vasodilators. 

Substituted anilines behave similarly to the phenols, although relatively little data are available. A-phenyl-iV -isopropyl-p-phenylenediamine is an efficient inhibitor in the polymerization of styrene only in the presence of oxygen [Winkler and Nauman, 1988], However, the effectiveness of phenothiazine as an inhibitor in the polymerization of acrylic acid is independent of oxygen [Levy, 1985],... 

---