Immunostimulant effect

Shin, J.Y. et al., Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function, Immunopharmacol Immunotoxicol, 24, 469, 2002. 

Amer, S., K.J. Na, M. El-Abasy, M. Motobu, Y. Koyama, K. Koge, and Y. Hirota. Immunostimulating effects of sugar cane extract on X-ray radiation induced immunosuppression in the chicken. Int Immunopharmacol 2004 4(1) 71-77. 

There are several botanicals that have purported immunostimulating effects. These include Panax ginseng and Echinacea purpurea (74), which have both been used as an immune stimulant. Any potential adverse effect on the pharmacological activity of immunosuppressants has not been reported in patients or evaluated in clinical studies. Given the lack of data, it would be prudent to advise against concurrent intake of these botanicals, and closely monitor changes in efficacy in patients who self-administer these botanicals. 

The immunostimulating activity of chitosan has also been reported. A 70% DD chitosan showed immunostimulating effects by activating macrophages and natural killer cells in rats when infected with . coli and Sendai virus (Nishimura et al., 1984). Chang et al. (2004) also reported the immune-enhancing effects of chitosan as a novel adjuvant to an inactivated influenza vaccine, and the antibody content in serum remarkably increased the antiviral defenses of mice. 

In order to study the immunostimulating effect of l-(chloromethyl)-3,7,10-trimethylsilatrane investigations were made of the weight coefficients of immunocompetent organs (thymus and spleen), the total leucocytes and erythrocytes in peripheral blood, titre of blood complement, the amount of antigen-reactive ro-sula-forming lymphocytes in spleen and thymus, microbial dissemination of skin as well as skin test with trypan blue. 

The immunostimulating effect of l-(chloromethyl)-3,7,10-trimethylsilatrane administered at 50-100 mg/kg doses to healthy animals is manifested not only by an increase in the weight coefficients and the RFL level of thymus and spleen but also by an enlarged total amount of leucocytes in peripheral blood (on an average from 9700 to 14300 per mm3) and a slight increase in the positive function of cellular and fibrous structures of skin. 

A decrease in a daily dose to 20 mg/kg is followed by a reduced immunostimulating effect of l-(chloromethyl)-3,7,10-trimethylsilatrane. An increase in the dose to 250 mg/kg leads to a considerable lowering of the weight coefficients of thymus as compared to the control. 

The above data permit the conclusion that l-(chloromethyl)silatrane and l-(chloromethyl)-3,7,10-trimethylsilatrane show a certain immunostimulating effect. This effect is displayed by an increase in leucopoiesis and a number of other immunological factors and seems to favour the inhibition of the growth of some experimental neoplasms. 

Chamomile has been used medicinally since the time of ancient Rome for its purported sedative, antispasmodic, and antirheumatic effects. Today, it is used topically to treat a variety of inflammatory conditions involving the mouth, skin, respiratory tract (via inhalation), and gastrointestinal tract. It is also used internally as a gastrointestinal antispasmodic and an anti-inflammatory agent. Chamomile is believed to have sedative, hypnotic, analgesic, and immunostimulant effects. 

CANNABIS ECHINACEA AND OTHER IMMUNOSTIMULANTS May i immunostimulant effects The cannabinoid receptor is considered to mediate immunosuppressant effects and is currently being investigated in the development of novel immunosuppressants Be aware... 

At a higher concentration, paclitaxel exhibits immunostimulating effects, e.g., lipopolysaccharide (LPS)-like and tumor necrosis factor (TNF)-like activity. 

Immunotherapy derives from an observation in the 19th century that cancer sometimes regressed after acute bacterial infections, i.e. in response to nonspecific immunostimulant effect. But, in general, it... 

Astr ali radix" (AR) [83] is an important traditional Chinese herbal medicine widely used in China and Japan. It is used to improve naturally weak constitutions, as an invigorating drug to improve the immune response, often for the elderly, and to coxmter unbalanced nutrition in China. The immunostimulant effect of polysaccharides, isolated from A. membranaceus, has been proved so many authors recommend that this plant may be used in immunotherapy. It is chiefly used as a decoction. 

Immunostimulant effects of garlic include an increase in proliferation of lymphocyte and macrophage phagocytosis, induction of the infiltration of lymphocytes and macrophages in transplanted tumors, induction of splenic hypertrophy, increased release of interleukin (IL)-2, interferon-y, and tumor necrosis factor-a, and enhancement of natural killer cell activity. It is thought that these effects may be mechanisms of cancer prevention (49). Lau and colleagues tested an aqueous garlic extract from Japan, the protein fraction isolated from this same extract, and three additional extracts obtained from health food stores in Loma Linda, CA, for ability to stimulate murine T-lym-... 

Table 4.8 Mixtures that Evoke Immunostimulant Effects...

The mistletoe lectins (m.w. 60-120,000) have, in very low doses, an immunostimulating effect. The F-lymphocyte stimulant effect of several plant lectins is known. 

The immunostimulating effects of the saponin analogs are somewhat similar to those observed with the acylated quillaja saponins. Although less effective than quillaja saponins, increasing doses of the analogs elicited... 

The immunostimulating effect of SPs is mainly based on macrophages modulation. Macrophages are the residence of immime cells in the innate immune system which plays an important role in the maintenance of homeostasis by changing their function according to the tissue. As the... 

Moon, J. S., Kim, H. K., Koo, H. C. et al. 2007. The antibacterial and immunostimulating effects of chito-san-oligosaccharides against infection by Staphylococcus aureus isolated from bovine mastitis. Appl. Microbiol. Biotechnol. 75 989-998. 

Particle based adjuvant endow hopeful signs on transporting antigen to immune cells and behaving as stimulators to elicit preventive or therapeutic response. Nevertheless, the wide size distribution of existing polymeric particles has so far masked the immunostimulative effects of particle adjuvant, and compromised the development in pharmacological researches [60], To overcome this obstacle, Yue et al. has conceded out a series of research activities regarding the particulate... 

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