Identification and assessment

C. Desbrow, E. Routledge, D. Sheehan, M. Waldock and J. Sumpter, in The Identification and Assessment of Oestrogen Substances in Sewage Treatmen t Works Effinents, Environment Agency, Bristol, 1996. 

Gillesby BE, Zacharewski TR. 1998. Exoestrogens Mechanisms of action and strategies for identification and assessment. Environ Toxicol Chem 17(1) 3-14. 

Kletz, T.AT (1983) HAZOP and HAZAN — Notes on the Identification and Assessment of Hazards, Instn of Chem. Eng., London. 

Koller, G. (2000) Identification and Assessment of Relevant Environmental, Health and Safety Aspects during Early Phases of Process Development. Technische Wissenschaften Eth Zurich, Zurich. 

Conducting periodic inspections is an excellent method to verify the implementation of good housekeeping measures. Inspections may be especially important in the areas identified in the release identification and assessment step where releases have previously occurred. 

Davies, K. R., "Techniques for the Identification and Assessment of Major Acd-dent Hazards," I. Chem. Eng. Symposium Series, 93,289 (1985). 

The analyze phase of the project consists of the activities which are typically associated with , including identification and assessment of potential sensor technologies, method development, qualification, and validation. In addition, designed experiments (DOE) or data-mining exercises may be performed to... 

Some properties of these compounds that facilitate identification and assessment of purity are given in the Table I. All the compounds are air stable in the solid state as well as in solution. They are soluble in dichloromethane, acetonitrile, and nitromethane less soluble in chloroform and acetone, and insoluble in alcohols, ethers, and alkanes. The complex [RuC12(>/4-C8H12) (NCCH3)2] is also soluble in water. It may therefore have an extensive aqueous chemistry. 

Possible transformation products can be numerous and their identification and assessment are both costly and time consuming. Transformation normally causes a change in the physicochemical and (eco)toxicological properties, that is, transformation products have different environmental fates and effects. A risk assessment of such compounds is often not feasible because these chemicals are not available in the amounts needed for testing, and their identities may not even be known. 

Identification and assessment of risk. When a reasonably foreseeable risk is identified, the responsible individual should appoint a person to take managerial responsibility and to provide supervision for the implementation of precautions. 

Robock SH (1971) Political risk identification and assessment. Columbia Journal of World Business 6 6-20 Rohm and Haas (2006) Annual report 2005. 

Stinging and Irritating Substances Their Identification and Assessment... 

Chapter 39 Stinging and Irritating Substances Their Identification and Assessment 501 Karen Cooper, Marie Marriott, Lisa Peters, and David Basketter... 

Zacharewski, T., Identification and assessment of endocrine disruptors Limitations of in vivo and in vitro assays, Environ. Health Perspect., 106 (Suppl. 2), 577-582, 1998. 

For one, the system did not produce sufficient information about the effects of the majority of existing chemicals on human health and the environment. Risk identification and assessment covering the potential hazards of a substance... 

Examples of product class carcinogenicity hazard identifications and assessments and ultimate risk communications for biopharmaceuticals approved in the United States for chronic use or based on potential cause for concern are provided in Table 19.4a (products without carcinogenicity assessment) and Table 19.4b (products with carcinogenicity assessment). The data are derived from publicly available regulatory assessments and product labels. Specific examples are discussed below. 

Identification and assessment of inherent hazardous properties of, and possible risks with, chemicals... 

Six known and two new metabolites of glyburide, a sulfonylurea dmg applied in the treatment of insulin-independent Diabetes mellitus, were identified using DDA in LC-MS" on an ion-trap instmment [39]. DDA was also applied as an alternative to precursor-ion analysis in the screening and identification of moclobemide and remikiren metabolites [32]. More recently, ion-trap MS-MS in DDA mode was applied to perform the simultaneous metabolite identification and assessment of metabolic stability [40-41]... 

Reflectance peak sensitive to leaf area, vegetation density, biomass Species identification and assessment of vegetation vigour... 

In 1991, the National Academy of Sciences studied the health effects attributable to toxic waste sites and concluded, [W]e find that the health of some members of the public is in danger, but We are currently unable to answer the question of the overall impact on public health of hazardous wastes. The Academy pointed out that Millions of tons of hazardous materials are slowly migrating into groundwater in areas where they could pose problems in the future, even though current risks could be negligible. The Academy concluded, ...the committee does find sufficient evidence that hazardous wastes have produced health effects in some populations. We are concerned that populations may be at risk that have not been adequately identified, because of the inadequate program of site identification and assessment. ... 

Styrene-7,8-oxide (styrene oxide), the major metabolite of the commercially important chemical styrene, was used as a model electrophile. Styrene is widely used in the manufacture of reinforced plastics and occupational exposure occurs mainly through inhalation of the vapor (14.). The metabolite styrene oxide is mutagenic in both prokaryotic (12) and eukaryotic test systems (16.171 and carcinogenic in rodents (18.). The formation of covalent DNA adducts with styrene oxide in vitro has been reported (18), therefore the development of procedures with the potential for the identification and assessment of styrene oxide damage in vivo clearly need to be explored. 

Hartman, DE. 1995. Neuropsychological toxicology Identification and assessment of human neurotoxic syndromes (second edition). New York, NY Plenum Press, 132-133. 

As discussed in the chapter on Drug Surveillance, the safety surveillance mission is to implement the systematic review of spontaneous post-marketing data for proactive risk identification and assessment. In general, signal generation is done using clinical trials data, the medical literature, knowledge of class effects and spontaneous reports. 

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