Hydrate particle size distribution

J. S. Pic, J. M. Herri, and M. Coumil. Experimental influence of kinetic inhibitors on methane hydrate particle size distribution during batch crystallization in water. Can J Chem Eng, 79(3) 374-383, June 2001. 

Laser scattering—focused beam reflectance method, FBRM with high P cell (Clarke and Bishnoi, 2004) Yes P, T, particle formation (min) 1500 psi size range 1-1000 pm stirred Hydrate particle size distribution during growth/decomposition... 

Laser scattering methods have been applied by the groups of Bishnoi and Sloan to measure changes in the hydrate particle size distribution during hydrate... 

Brown et al. [494] developed a method for the production of hydrated niobium or tantalum pentoxide from fluoride-containing solutions. The essence of the method is that the fluorotantalic or oxyfluoroniobic acid solution is mixed in stages with aqueous ammonia at controlled pH, temperature, and precipitation time. The above conditions enable to produce tantalum or niobium hydroxides with a narrow particle size distribution. The precipitated hydroxides are calcinated at temperatures above 790°C, yielding tantalum oxide powder that is characterized by a pack density of approximately 3 g/cm3. Niobium oxide is obtained by thermal treatment of niobium hydroxide at temperatures above 650°C. The product obtained has a pack density of approximately 1.8 g/cm3. The specific surface area of tantalum oxide and niobium oxide is nominally about 3 or 2 m2/g, respectively. 

Suhtnicion nickel powders luive been synthesized successfully from aqueous NiCh at various tempmatuTKi and times with ethanol-water solvent by using the conventional and ultrasonic chemical reduction method. The reductive condition was prepared by flie dissolution of hydrazine hydrate into basic solution. The samples synthesized in various conditions weae claractsiz by the m ins of an X-ray diffractometry (XRD), a scanning electron microscopy (SEM), a thermo-gravimetry (TG) and an X-ray photoelectron spectroscopy (XPS). It was found that the samples obtained by the ultrasonic method were more smoothly spherical in shape, smaller in size and narrower in particle size distribution, compared to the conventional one. 

Modified amino acids such as N-acyl-dehydroalanine polymers and copolymers with N-vinyl-N-methyl acetamide seem to be particularly effective [396]. The crystallization kinetics in the presence of polyvinylpyrrolidone and tyrosine have been tested by time-resolved experiments [981]. An influence is evident on the particle size distribution of the hydrate [1433]. 

A mechanistic model for the kinetics of gas hydrate formation was proposed by Englezos et al. (1987). The model contains one adjustable parameter for each gas hydrate forming substance. The parameters for methane and ethane were determined from experimental data in a semi-batch agitated gas-liquid vessel. During a typical experiment in such a vessel one monitors the rate of methane or ethane gas consumption, the temperature and the pressure. Gas hydrate formation is a crystallization process but the fact that it occurs from a gas-liquid system under pressure makes it difficult to measure and monitor in situ the particle size and particle size distribution as well as the concentration of the methane or ethane in the water phase. 

In preparing akara from each milled product, too many large particles still remained in the 2 mm material to make a smooth paste. However, highly acceptable akara with uniform shape was produced from this material after the paste was ground to eliminate the large particles. With the 0.5 mm screen, the paste was very fluid and extremely difficult to dispense, behavior which closely resembled that exhibited by the commercial cowpea flour. Akara prepared from the 0.5 mm material was also extremely distorted. Of the three screen sizes compared, the 1.0 mm screen produced the most desirable particle size distribution although the paste produced from the 1.0 mm material was somewhat more fluid than desired, it appeared that adjustments could be made in hydration of the meal to achieve an appropriate batter viscosity. 

The mechanism of the action of zinc phosphate is shown in Figure 69. Zinc phosphate dihydrate pigment is hydrated to the tetrahydrate in an alkyd resin binder [5.84], The tetrahydrate is then hydrolyzed to form zinc hydroxide and secondary phosphate ions which form a protective film of basic iron(III) phosphate on the iron surface [5.80]. The anticorrosive action of zinc phosphate depends on its particle size distribution. Micronization improves the anticorrosive properties [5.85]-[5.87], The effect of corrosion-promoting ions on the anticorrosive properties of zinc phosphate is described in [5.88], [5.89],... 

In essence, the test battery should include XRPD to characterize crystallinity of excipients, moisture analysis to confirm crystallinity and hydration state of excipients, bulk density to ensure reproducibility in the blending process, and particle size distribution to ensure consistent mixing and compaction of powder blends. Often three-point PSD limits are needed for excipients. Also, morphic forms of excipients should be clearly specified and controlled as changes may impact powder flow and compactibility of blends. XRPD, DSC, SEM, and FTIR spectroscopy techniques may often be applied to characterize and control polymorphic and hydrate composition critical to the function of the excipients. Additionally, moisture sorption studies, Raman mapping, surface area analysis, particle size analysis, and KF analysis may show whether excipients possess the desired polymorphic state and whether significant amounts of amorphous components are present. Together, these studies will ensure lotto-lot consistency in the physical properties that assure flow, compaction, minimal segregation, and compunction ability of excipients used in low-dose formulations. 

By definition, the kinetic curve of a cement is the weighted sum of the curves for its constituent phases as they occur in that cement. The reactivities of individual clinker phases were considered in Section 4.5 and some effects of particle size distribution, which is a particularly important variable, in Section 4.1.4. Although many data relating particle size distribution directly to strength exist, much less is known about its relation to degrees of reaction. Parrott and Killoh (P30) presented data indicating that the rate of hydration, as represented by that of heat evolution, was proportional to the specific surface area during the period of hydration in which the rate was controlled by diffusion. 

The kinetics of cement hydration are dominated by the effects associated with the particle size distribution of the starting material, and attempts to explain them in which this is ignored can lead to very misleading results (T41,B98,B105,K37,J27,K38,K39). Even laboratory-prepared samples with close distributions (e.g. 2-5 pm) (K20) are far from monodisperse from the kinetic standpoint. Two approaches to the resulting problems of interpretation will be considered. 

Knudsen s model led to the prediction that, if linear kinetics were followed, the age at which 50% of the cement has hydrated is proportional to the fineness constant (or xj in the Rosin/Rammler distribution (equation 4.1) for parabolic kinetics, it predicted that this age is proportional to (K40). Evidence was presented in support of this conclusion for cements considered to follow linear kinetics. The theory did not predict any relation to the breadth of the particle size distribution, which is represented by the slope of the Rosin-Rammler curve. 

Moisture content slightly hygroscopic. A well-defined crystalline hydrate is not formed although surface moisture may be picked up or contained within small pores in the crystal structure. At relative humidities between about 15% and 65%, the equilibrium moisture content at 25°C is about 2.0%. At relative humidities above about 75%, tribasic calcium phosphate may absorb small amounts of moisture. Particle size distribution Tribasic calcium phosphate powder typical particle diameter 5-10 pm 98% of particles <44 pm. 

Particle size distribution 100% of particles less than 106 pm in size. Average particle size is 35-55 pm for Explotab. Solubility sparingly soluble in ethanol (95%) practically insoluble in water. At a concentration of 2% w/v sodium starch glycolate disperses in cold water and settles in the form of a highly hydrated layer. 

Kinetic measurements are changing from macroscopic to microscopic scales. Initially, kinetics consisted of macroscopic measurements of the fluid phases associated with hydrates - such as gas consumption rates or liquid turbidity, fundamentally in Bishnoi s laboratory.Subsequently, mesoscopic measurements of hydrate cry-stais, -82 particle size distribution, and film growth rates are available. Microscopic kinetic hydrate phase measurements are emerging. A review of microscopic hydrate science for both kinetics and thermodynamics is presented by... 

The model is formulated on the premise that the decomposing hydrate particle is surrounded by a cloud of the product gas hence the driving force for the decomposition process is expressed in terms of the fugacity difference given in Eq. (1). The process of decomposition possibly involves (1) destruction of the clathrate host (water) lattice at the surface of the particle, and (2) and desorption of the guest (hydrate former) molecules from the surface. The particle size distribution was incorporated in the calculations for the determination of the intrinsic rate constants.The following Arrhenius type equation is used to represent the effect of temperature on the intrinsic rate constant ... 

DHTDMAC vesicles have been characterized by Okumura et al. [92], The width of the bimolecular layer is 50 A, and the interlamellar spacing is between 100 and 400 A. Each DHTDMAC molecule is hydrated with 7 water molecules. The particle size distribution, measured by dynamic light scattering and optical microscopy, is very broad, ranging from 0.1 to 10 p,m. This may be assigned to the presence of both unilamellar and multilamellar vesicles in the dispersion. 

If the drug is insufficiently soluble to allow delivery of the required dose as a solution (the maximum delivered dose for each nostril is 200 p,L), then a suspension formulation will be required. There are additional issues for suspension products, for example crystal growth, physical stability, resuspension, homogeneity and dose uniformity. Suspension products will also require information on density, particle size distribution, particle morphology, solvates and hydrates, polymorphs, amorphous forms, moisture and/or residual solvent content and microbial quality (sterile filtration of the bulk liquid during manufacture is not feasible). 

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