Methyl acetamide

Figure 5.65 The dependence of the acetamide methyl-rotation barrier (AT ) on NRT bond-order differences in the amide group (Ab = bco - cn) for various H-bonded complexes of the pseudo-cA (occH(in) = 0°) rotamer (see Table 5.27).

N-Methyl acetamide Methyl acetate Methyl acetylene Methyl acrylate Methyl amine Methyl benzoate 3-Methyl- 1,2-butadiene 2-Methylbutane... 

Methylphenyl)acetamide / /-Methyl-/ /-phenylacetamide 2-Methylphenyl acetate 3-Methylphenyl acetate... 

N, 0-Bis-(trimethylsilyl)acetamide Methyl-3a-carboxybenzylaminocrotonate sodium salt Methyl chloroformate... 

Glycol ricinoleate Meroxapol 105 Meroxapol 252 Meroxapol 254 Meroxapol 258 PEG-3 dicaprylate/caprate Triaryl phosphate plasticizer, latex coatings Diethylene glycol dibenzoate plasticizer, latex modification Polyvinyl methyl ether plasticizer, leather Acetamide Methyl cocoate Methyl hydroxyethylcellulose Methyl tallowate PEG-8 cocoate... 

The reduction of 223 was carried out in ethanol (25°C, 90psi of H2-pressure) in the presence of 1 mol% of the Ru-based catalyst having t-Bu-Josiphos ligand of Ph2P-F-C-P (r-Bu)2 structure and 0.5 equivalents of NEta. Amino acid (R)-224 was obtained with 98% of yield and 97% ee. It has to be noted that Burk et al. hydrogenated the acetamide-methyl ester of the tetrahydropyran intermediate with [Rh(Me-BPE)(COD)]OTf precatalyst with enantioselec-tivity of 98%... 

The acetamide often contains a minute amount of impurity having an odour resembling mice excrement this can be removed by washing with a small volume of a 10 per cent, solution of ethyl alcohol in ether or by recrystallLsation. Dissolve 5 g. of impure acetamide in a mixture of 5 ml. of benzene and 1 5 ml. of dry ethyl acetate warm on a water bath until all is dissolved and cool rapidly in ice or cold water. Filter oflF the crystals, press between Alter paper and dry in a desiccator. The unpleasant odour is absent and the pure acetamide melts at 81°. Beautiful large crystals may be obtained by dissolving the acetamide (5 g.) in warm methyl alcohol (4 ml.), adding ether (40 ml.) and allowing to stand. 

The functions of the potassium carbonate are (a) to neutralise the acetic acid arising from the action of the phosphoric acid upon the acetamide, and (6) to salt out the otherwise soluble methyl cyanide as an upper layer. 

Acetyl chloride Acetic anhydnde Methyl acetate Acetamide... 

Technora. In 1985, Teijin Ltd. introduced Technora fiber, previously known as HM-50, into the high performance fiber market. Technora is based on the 1 1 copolyterephthalamide of 3,4 -diaminodiphenyl ether and/ -phenylenediamine (8). Technora is a whoUy aromatic copolyamide of PPT, modified with a crankshaft-shaped comonomer, which results in the formation of isotropic solutions that then become anisotropic during the shear alignment during spinning. The polymer is synthesized by the low temperature polymerization of/ -phenylenediamine, 3,4 -diaminophenyl ether, and terephthaloyl chloride in an amide solvent containing a small amount of an alkaU salt. Calcium chloride or lithium chloride is used as the alkaU salt. The solvents used are hexamethylphosphoramide (HMPA), A/-methyl-2-pyrrohdinone (NMP), and dimethyl acetamide (DMAc). The stmcture of Technora is as follows ... 

Peroxide-Ketazine Process. Elf Atochem in France operates a process patented by Produits Chimiques Ugine Kuhhnaim (PCUK). Hydrogen peroxide (qv), rather than chlorine or hypochlorite, is used to oxidize ammonia. The reaction is carried out in the presence of methyl ethyl ketone (MEK) at atmospheric pressure and 50°C. The ratio of H202 MEK NH2 used is 1 2 4. Hydrogen peroxide is activated by acetamide and disodium hydrogen phosphate (117). Eigure 6 is a simplified flow sheet of this process. The overall reaction results in the formation of methyl ethyl ketazine [5921-54-0] (39) and water ... 

The methyl ethyl ketazine forms an immiscible upper organic layer easily removed by decantation. The lower, aqueous phase, containing acetamide and sodium phosphate, is concentrated to remove water formed in the reaction and is then recycled to the reactor after a purge of water-soluble impurities. Organic by-products are separated from the ketazine layer by distillation. The purified ketazine is then hydrolyzed under pressure (0.2—1.5 MPa (2—15 atm)) to give aqueous hydrazine and methyl ethyl ketone overhead, which is recycled (122). The aqueous hydrazine is concentrated in a final distillation column. 

Nucleophilic Substitution Route. Commercial synthesis of poly(arylethersulfone)s is accompHshed almost exclusively via the nucleophilic substitution polycondensation route. This synthesis route, discovered at Union Carbide in the early 1960s (3,4), involves reaction of the bisphenol of choice with 4,4 -dichlorodiphenylsulfone in a dipolar aprotic solvent in the presence of an alkaUbase. Examples of dipolar aprotic solvents include A/-methyl-2-pyrrohdinone (NMP), dimethyl acetamide (DMAc), sulfolane, and dimethyl sulfoxide (DMSO). Examples of suitable bases are sodium hydroxide, potassium hydroxide, and potassium carbonate. In the case of polysulfone (PSE) synthesis, the reaction is a two-step process in which the dialkah metal salt of bisphenol A (1) is first formed in situ from bisphenol A [80-05-7] by reaction with the base (eg, two molar equivalents of NaOH),... 

A7, A/-dimethyl-2-methylcarbamoyloxyimiao-2-(methyl thio)acetamide Vydate / ox amyl iasecticide... 

Isomer separation beyond physical fractional crystallization has been accompHshed by derivatization using methyl formate to make /V-formyl derivatives and acetic anhydride to prepare the corresponding acetamides (1). Alkaline hydrolysis regenerates the analytically pure amine configurational isomers. 

Esters are named by replacing the ending -ic acid with the suffix -ate. The alcohol portion of the ester is named by replacing the -ane ending of the parent hydrocarbon name with the suffix -yl. The alkyl radical name of an ester is separated from the carboxylate name, eg, methyl formate for HCOOCH. Amides are named by changing the ending -oic acid to -amide for either systematic or common names, eg, hexanamide and acetamide. 

Several triazinyl ketones isomerize to 4-acetamidopyrimidines. TTiis is seen in the C-acylation of 2,4,6-trimethyl-l,3,5-triazine (708) with benzoyl chloride in the presence of sodium amide to give the ketone (709) which undergoes a Dimroth-like rearrangement in boiling water to afford A-(2-methyl-6-phenylpyrimidin-4-yl)acetamide (710) it can be seen that the acylating agent determines the identity of the 6-substituent 64JHC145). 

Acetamide [60-35-5] M 59.1, m 81 , pK -1.4, pKl +0.37. Crystd by soln in hot MeOH (0.8mL7g), diltd with Et20 and allowed to stand [Wagner J Chem Educ 7 1135 1930]. Alternate cry sms are from acetone, benzene, chloroform, dioxane, methyl acetate or from benzene-ethyl acetate mixture (3 1 and 1 1). It has also been recrystd from hot water after treating with HCl-washed activated charcoal (which had been... 

In a 1-1, three-necked, round-bottomed flask equipped with a calcium chloride drying tube, a mechanical stirrer, and a ground-glass stopper are placed 28.2 g. (0.184 mole) of freshly distilled methyl bromoacetate, 500 ml. of anhydrous iV,iV-dimethy]acetamide (Note 1), and 20.0 g, (0.168 mole) of methyl nitroacetate (Note 2). The solution is stirred vigorously while 146 ml. (0.168 mole) of 1.15N sodium methoxide in... 

N,N-Dimethylacetamide 100 mmol N-methyl acetamide/mol creatinine in urine (HGV) Post shift... 

Diisopropyl ether, see Isopropyl ether Dimethoxymethane, see Methylal Dimethyl acetamide Dimethylamine... 

The phosphorus pentoxide is introduced into a small distilling flask (200 c.c.) attached to a short condenser. As the pentoxide absorbs moisture rapidly and becomes sticky, it is convenient to push the neck of the distilling flask through a cork which fits the phosphorus pentoxide bottle, and then to shake in the oxide until the required weight is obtained. The powdered acetamide is immediately introduced and shaken up, and the mixture distilled over a small flame, which is constantly moved about. Add to the distillate about half its volume of water, and then solid potassium carbonate, until no more dissolves. The upper layer of liquid, which consists of methyl cyanide, is separated and distilled over a little fresh phosphorus pentoxide with thermometer. Yield, about 5 grams. 

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