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Hyaluronidases inhibition

Guerra, F., Hyaluronidase inhibition by sodium salicylate in rheumatic fever, Science, 103, 686, 1946. [Pg.275]

The available evidence does not allow a definite conclusion to be made, especially as much of the animal work has been performed with rather high doses of the drugs. It seems unlikely, however, that hyaluronidase inhibition plays a major role in clinical antirheumatic activity. [Pg.123]

Qlick, D., Good, T. A., and Bittner, j. j. Mucolytic enzyme systems. IV. Relationship of hyaluronidase inhibition by blood serum to incidence 166. of mammary cancer in mice. Proc. Soc. Exp. Biol. Med., 69 524-526. [Pg.608]

The PL-catechin conjugate showed greatly amplified concentration-dependent inhibition activity against bacterial collagenase (ChC) on the basis of the catechin unit, which is considered to be due to effective multivalent interaction between ChC and the catechin unit in the conjugate. The kinetic study suggests that this conjugate is a mixed-type inhibitor for ChC. Hyaluronidase is an enzyme which catalyzes hydrolysis of hyaluronic acid and is often involved in a number... [Pg.242]

Echinacea extracts appear to stimulate the number and activity of immune cells (i.e., increasing physiological levels of tumor necrosis factor and other cytokines) and to increase leukocyte mobility and phagocytosis. The extracts also have antiviral and antiinflammatory properties and inhibit bacterial hyaluronidase. [Pg.788]

Certain echinacea constituents have demonstrated anti-inflammatory properties in vitro. Inhibition of cyclooxygenase, 5-lipoxygenase, and hyaluronidase may be involved. In animals, application of Epurpurea prior to application of a topical irritant reduced both paw and ear edema. Despite these laboratory findings, randomized, controlled clinical trials involving echinacea for wound healing have not been performed in humans. [Pg.1355]

Chlorogenic and caffeic acids inhibit the activation of hyaluronidase, which is known as one of the enzymes involved in allergic effects [79], migration of cancer cells [80], inflammation [81, 82], and increased permeability of the vascular system. The superoxide anion radical scavenging activity of chlorogenic acids correlates linearly to the hyaluronidase-inhibitory activity. (3-Hexosaminidase release from rat basophilic leukemia cells induced by antigen has been inhibited by chlorogenic and caffeic acids. These compounds do not inhibit 13-hexosaminidase activity itself. [Pg.939]

Flavonoids are well known as inhibitors of hyaluronidase. Li 1950 Rodney et al, reported the effect of several flavonoids on hyaluronidase using in vitro and in vivo methods [79], Knppusamy et al. investigated the structure-activity relationship of die flavonoids as inhibitors of testicular hyaluronidase [80] and hyaluronidase from snake, scorpion, and bee venom [81]. They showed that flavones. flavanols. and chalcones possess the general ability to inhibit hyaluronidase Kinetic investigations showed that these compounds acted as competitive inhibitors [80]. Several hyaluronidase inhibitors were shown to be able to delay the action of snake venom when injected into mice [8ll One caimnt rule out the possible interaction of the flavonoids with other components of the venom, as the inhibitory effects of flavonoids are not specific to hyaluronidase... [Pg.166]

This technique is a histochemical procedure to evaluate die hyahuonidase activity of spermatozoa. Using this technique, Waibel el al. evaluated the inhibition of mouse testicular hyaluronidase by sodium aurothiomalate [147]. Hirayama et al. [Pg.176]

If inhibition of HA degradation by hyaluronidase occurs, then a class of molecules that have not been explored, the hyaluronidase inhibitors, are very important. It can be postulated that with extreme stress, hyaluronidase inhibitors would be found in the circulation as acute phase proteins, the stress response products synthesized by the liver. These would prevent the ever-present rapid destruction and allow levels of HA to quickly increase. [Pg.260]

Grais, M.L. and Glick, D., Mucolytic enzyme systems. II. Inhibition of hyaluronidase by serum in skin diseases, J. Invest. Dermatol., 257, 259, 1948. [Pg.275]

Li, M.W. et al., Inhibition of monkey sperm hyaluronidase activity and heterologous cumulus penetration by flavonoids, Biol. Reprod., 56, 1383, 1997. [Pg.275]

Wolf, R.A. et al., Heparin inhibits bovine testicular hyaluronidase activity in myocardium of dogs with coronary artery occlusion, Am. J. Card., 53, 941, 1984. [Pg.275]

Seifter, J., and Baeder, D. H., Lipemia clearing by hyaluronidase, hyaluronate, and desoxycorticosterone, and its inhibition by cortisone, stress, and nephrosis. Proc. Soc. Exptl. Biol. Med. 86, 709-713 (1954). [Pg.232]

In a study of human sperm, Echinacea was found to inhibit the motility of the sperm only at high concentrations and after 24 hours. One potential effect of Echinacea is thought to be the inhibition of hyaluronidase activity. Hyaluronidase is localized on the sperm head and helps the sperm to penetrate the oocyte. This potential inhibition could prevent sperm from fertilizing oocytes, but further studies are needed to confirm this potential interaction (38). [Pg.106]

Studies on the activity of rabbit sperm acrosomal enzymes have indicated that gossypol at 12-76 pM could significantly inactivate azocoll proteinase, acrosin, neuraminidase, and arylsulfatase. Hyaluronidase, p-glucuronidase, and acid phosphatase were also inhibited at a higher concentration of gossypol (380 pM) (Yuan et al., 1995). Since acrosomal enzymes play important roles in the fertilization process, the inhibition of... [Pg.236]


See other pages where Hyaluronidases inhibition is mentioned: [Pg.47]    [Pg.335]    [Pg.597]    [Pg.370]    [Pg.47]    [Pg.335]    [Pg.597]    [Pg.370]    [Pg.528]    [Pg.243]    [Pg.49]    [Pg.55]    [Pg.294]    [Pg.510]    [Pg.223]    [Pg.166]    [Pg.167]    [Pg.168]    [Pg.177]    [Pg.249]    [Pg.275]    [Pg.275]    [Pg.154]    [Pg.394]    [Pg.239]    [Pg.907]    [Pg.824]    [Pg.256]    [Pg.277]   
See also in sourсe #XX -- [ Pg.335 ]




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Echinacea hyaluronidase inhibition

Flavonoids hyaluronidase inhibition

Hyaluronidase

Inhibition of hyaluronidase

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