Bacterial Inhibition

Inoue et al. [41] studied the elimination of triclosan by MnP from P. chrysosporium, and LAC from T. versicolor. MnP (0.5 nkat mL-1) was the most efficient, achieving a removal of 94% after 30 min and almost complete after 60 min, while LAC (2.0 nkat mL-1) and LAC-HBT removed triclosan at 51% and 66%, respectively. Moreover, the treatment with MnP resulted in the complete loss of bacterial inhibition activity after 30 min and reduced the algal growth inhibition by 90% after 60 min. Similar results were obtained by Kim and Nicell [40] with LAC from T. versicolor after 6 h, with concomitant reduction in toxicity even without mediators. 

In addition to bacterial inhibition, furanones from D. pulchra directly inhibit settlement and attachment of some species of biofouling larvae and zoospores (de Nys et al. 1995 Dwoijanyn et al. 2006), demonstrating the broad-spectrum antifouling activity of these molecules. However, the molecular mechanisms by which furanones deter larvae and zoospores are not known. 

The Guthrie test is a bacterial inhibition assay for the measurement of phenylalanine. 

The calf antibiotic and sulfa test (CAST), the fast antimicrobial screen test (FAST), and the swab test on premises (STOP) are all bacterial inhibition tests developed at the US Department of Agriculture Food Safety and Inspection Services to screen kidneys for antimicrobial drug residues at slaughter (97-101). For CAST and FAST, an incision is made with a knife, whereas for STOP the tissue is macerated with the shaft of the swab. For all three tests, cotton swabs are inserted into kidney tissue to soak up fluids. Swabs are then incubated on inoculated medium with a disc containing an antibiotic standard used to monitor the viability of the organism and its growth inhibition. 

The use of a biomarker for detecting metabolic disease began nearly 50 years ago when Robert Guthrie developed a bacterial inhibition assay to screen for... 

The information presented above provides evidence that a prime molecular target for the silver ion resides in cellular SH groups. Such interaction, depicted in Figure 7.1, as well as reversal by SH groups, would then be responsible for causing bacterial inhibition. 

Lamoureux, Diss. Abstr. B 28, 4908 (1968)- Bacterial inhibition Parsons etal. Antimicrob. Ag. Chemother. 19671 415. 

Bacterial inhibition by electrical activation of percutaneous silver implants. J Bone Miner Res 20 565-577. 

Korsrnd GO, Boison JO, Nonws JE, MacNeU JD. Bacterial inhibition tests nsed to screen for antimicrobial veterinary drng residnes in slanghtered animals, J. AOAC Int. 1998 81 21-24. 

Bacterial inhibition by metabolites analogs pantoyl taurine. Brit. J... 

Figure 5.1 Bacterial inhibition (left, untreated fabric right, antimicrobial-treated fabric).

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