Vascular system

Grafts are also frequently employed in the upper part of the body to reconstmct damaged portions of the aorta and carotid arteries. In addition, grafts are used to access the vascular system, such as in hemodialysis to avoid damage of vessels from repeated needle punctures. Most grafts are synthetic and made from materials such as Dacron or Teflon. Less than 5% of grafts utilized are made from biological materials. 

Blood Access Devices. An investigational device called the Osteoport system allows repeated access to the vascular system via an iatraosseous iafusion directiy iato the bone marrow. The port is implanted subcutaneously and secured iato a bone, such as the iUac crest. Medications are adrninistered as ia any conventional port, but are taken up by the venous sinusoids ia the marrow cavity, and from there enter the peripheral circulation (8). 

Impla.nta.ble Ports. The safest method of accessing the vascular system is by means of a vascular access device (VAD) or port. Older VAD designs protmded through the skin. The totally implanted ports are designed for convenience, near absence of infection, and ease of implantation. Ports allow dmgs and fluids to be deUvered directiy into the bloodstream without repeated insertion of needles into a vein. The primary recipients of totally implanted ports are patients receiving chemotherapy, bolus infusions of vesicants, parenteral nutrition, antibiotics, analgesics, and acquired immune disease syndrome (AIDS) medications. 

Several chemical compounds can have an adverse effect on the heart and the vascular system. The effect may first appear as a transient change in the cardiac function. However, prolonged exposure increases the risk of permanent effects. Occasionally, functional effects such as cardiac arrhythmias may even lead to death. Furthermore, in many cases the effects of chemicals... 

VEGFs, the angiopoietins, the Ephrins and Notch molecules stand out as they act specifically or preferentially on the vascular system and have, thus, to be considered as key regulatory molecules of the angiogenic cascade [3]. 

Platelets play a central role in primary hemostasis. They are also important in pathological processes leading to thrombosis. Antiplatelet drugs are primarily directed against platelets and inhibit platelet activation by a number of different mechanisms. They are used for the prevention and treatment of thrombotic processes, especially in the arterial vascular system. 

In the vascular system, endothelial ETB receptors mediate a transient vasodilation, whereas ETA receptors cause a long-lasting vasoconstriction. The role of ETb receptors expressed on smooth muscle cells... 

Mergia E, Friebe A, Dangel O et al (2006) Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest 116 1731-1737... 

Cramping sensation in the leg or buttock precipitated reproducibly by walking or exercise that occurs as a result of decreased oxygen supply due to severe atherosclerotic disease of the peripheral vascular system. It typically subsides after a brief rest. 

Non-neuronal cells (including astrocytes, mechan-osensory hair cells, macrophages, keratinocytes, endothelial cells of the vascular system, muscle cells, lymphocytes, intestinal epithelial cells and various cell-types of the lungs)... 

Histamine is a substance present in various tissues of die body, such as die heart, lungs, gastric mucosa, and skin (Pig. 36-1). The highest concentration of histamine is found in die basophil (a type of white blood cell) and mast cells diat are found near capillaries. Histamine is produced in response to injury. It acts on areas such as die vascular system and smooth muscle, producing dilatation of arterioles and an increased permeability of capillaries and venules. Dilatation of die arterioles results in localized redness. An increase in die permeability of... 

Mosses and liverworts (Bryophyta) are more complex than algae. Some of the larger species have structures that superficially appear similar to roots, stems and leaves, but they lack the internal conducting systems present in the vascular plants (Tracheophyta). Internal transport systems (vascular systems) make possible the large sizes of terrestrial plants where the soil is the source of some requisites (water, mineral nutrients) and the air is the source of others (CO2, sunlight). The different groups of vascular plants are characterized primarily by their methods of reproduction. Vascular plants are the source of all wood. 

III COL3A1 Extensible connective tissues such as skin, lung, and the vascular system... 

Cardiovascular disease (CVD) is characterized by the involvement of the heart and allied vascular system. High cholesterol, associated lipid abnormahties and high blood pressure are recognized as the major risk factors of CVD. There have been several animal experiments and clinical studies using rice bran and rice bran oil, which have demonstrated a hypocholesterolemic effect (Raghuram et al., 1989 Rukmini and Raghuram, 1991 Sugano and Tsuji, 1997). The mechanisms involved are briefly summarized. 

These results corroborated that alfalfa absorbed the Au(0) from the medium and translocated it through the vascular system. The EXAFS results (Figure 5, Table 3) showed that the Au atoms in plant samples had longer distances that the Au atoms in the tetrachloroaurate, but had equivalent distance to the Au atoms in the gold foil, which confirmed that the Au in plant samples was Au(0). 

Karlsson, K., Sandstrom, J., Edlund, A., Edlund, T. and Mark-lund, S.L. (1993). Pharmacokinetics of extracellular superoxide dismutase in the vascular system. Free Rad. Biol. Med. 14, 185-190. 

The pathophysiologic mechanisms of portal hypertension and of cirrhosis itself are entwined with the mechanisms of ascites (Fig. 19-3). Cirrhotic changes and the subsequent decrease in synthetic function lead to a decrease in production of albumin (hypoalbuminemia). Albumin is the major intravascular protein involved in maintaining oncotic pressure in the vascular system low serum albumin levels and increased capillary permeability allow fluid to leak from the vascular space into body tissues. This can result in peripheral edema, ascites, and fluid in the pulmonary system. The obstruction of hepatic sinusoids and... 

Because of the presence of anionic sites on the endothelium and on the glycocalyx layer, anionic macromolecules show a significantly slower rate of extravasation compared with neutral and cationic macromolecules. Kern and Swanson [39] found a threefold increase in the permeability of the pulmonary vascular system to cationic albumin, compared with native albumin of the same molecular weight and hydrodynamic radius. 

Although most drugs are absorbed from the intestine by the blood capillary network in the villi, they can also be taken up by the lymphatic system (an integral and necessary part of the vascular system, the function of which is to collect extra tissue fluid and return it to the vascular compartment), particularly by M cells that reside in the Peyer s patch regions of the intestine. Peyer s patches have also been implicated in the regulation of the secretory immune response. Wachsmann et al. [277] reported that an antigenic material encapsulated within a liposome, when administered perorally, is taken up by these M cells and exhibited better saliva and serum IgA (primary and secondary)... 

One more example of acute polychlorpinen poisoning occurred in the Ukraine around 1969-70, when 27 women aged 26-49 were sent out to sow collective farm fields three days after the fields had been treated with polychlorpinen. A warm rain washed the pesticide from the soil, and the pesticide evaporated intensively. All the women showed symptoms of acute poisoning 20-40 minutes later eight lost consciousness, and nine had fits. The poisoned women spent from 3-25 days in the regional hospital, after which they all went to the VNIIGINTOKS clinic with disruptions of the neural and cardio-vascular systems, as well as of the digestive tract over the next 9-13 months [43]. 

Platelets play a role in each of the mechanisms of normal hemostasis vasoconstriction, formation of the platelet plug, and blood coagulation. However, they are also involved in pathological processes that lead to atherosclerosis and thrombosis (formation of a blood clot within the vascular system). Antiplatelet drugs interfere with platelet function and are used to prevent the development of atherosclerosis and formation of arterial thrombi. 

Prevention of blood clotting in the normal vascular system. Several factors contribute to the prevention of blood clotting in the normal vascular system ... 

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