Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Inhibition potential

Strehblow FI-FI and Titze B 1977 Pitting potentials and inhibition potentials of iron and nickel for different aggressive and inhibiting anions Corn Scl 17 461-72... [Pg.2758]

Nitrate ions have a special influence by inhibiting pitting corrosion in neutral and acid waters atU> [Eq. (2-50)] [48,52], corresponds to a second pitting potential and is designated the inhibition potential. The system belongs to group IV, with pitting corrosion at U U... [Pg.63]

The development of biological tools to support DDI studies has paralleled the development of bioanalytical techniques. To better understand in vitro-in vivo (IVIV) correlations, the effects of differences in enzyme preparations and incubation conditions must be understood. Differences between enzyme preparations include nonspecific binding, the ratio of accessory proteins (cytochrome b5 and reductase) to CYPs and genetic variability differences in incubation conditions include buffer strength, the presence of inorganic cations and solvent effects. Understanding how biology influences enzymatic activity is crucial to accurate and consistent prediction of the inhibition potential. [Pg.206]

Moody, G.C., Griffin, S.J., Mather, A.N., McGinnity, D.F. and Riley, R.J. (1999) Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes assessment of human CYP inhibition potential. Xenobiotica, 29 (1), 53-75. [Pg.237]

Table 6—2. Inhibition potential of antidepressants at CYP450 enzyme systems... Table 6—2. Inhibition potential of antidepressants at CYP450 enzyme systems...
The short-term application of an increased dose rate of chemical inhibitor enhances the corrosion inhibiting potential of an already passivated metal surface. Nevertheless, in order to change the metal surface from an active state to a passive state, the electrode potential must be raised to a level above that of the passivation potential. Typically this is achieved by the use of chromate, nitrite, and/or orthophosphate in the presence of oxygen. [Pg.338]

Ray S, Sengupta C, Roy K. 2008. QSAR modeling for lipid peroxidation inhibition potential of flavonoids using topological and structural parameters. Cent Eur J Chem 6 267-276. [Pg.132]

The pharmacokinetics of available proton pump inhibitors are shown in Table 63-2. Their bioavailability is decreased approximately 50% by food hence, the drugs should be administered on an empty stomach. In a fasting state, only 10% of proton pumps are actively secreting acid and susceptible to inhibition. Proton pump inhibitors should be administered approximately 1 hour before a meal (usually breakfast or dinner), so that the peak serum concentration coincides with the maximal activity of proton pump secretion. The drugs have a short serum half-life of about 1.5 hours however, the duration of acid inhibition lasts up to 24 hours due to the irreversible inactivation of the proton pump. At least 18 hours are required for synthesis of new H+/K+ ATPase pump molecules. Because not all proton pumps are inactivated with the first dose of medication, up to 3-4 days of daily medication are required before the full acid-inhibiting potential is reached. Similarly, after stopping the drug, it takes 3-4 days for full acid secretion to return. [Pg.1477]

Acid is important in releasing vitamin B12 from food. A minor reduction in oral cyanocobalamin absorption occurs during proton pump inhibition, potentially leading to subnormal Bi2 levels with prolonged therapy. Acid also promotes absorption of food-bound minerals (iron, calcium, zinc) however, no mineral deficiencies have been reported with proton pump inhibitor therapy. [Pg.1480]

Fig. 1. Polarization curve of metals with active, passive and (a) transpassive potential range including oxygen evolution (b) passive potential range going directly to oxygen evolution (c) continuing passivity for valve metals to very positive potentials. Pitting between critical pitting lim and inhibition potential fsj in the presence of aggressive anions and inhibitors. Fig. 1. Polarization curve of metals with active, passive and (a) transpassive potential range including oxygen evolution (b) passive potential range going directly to oxygen evolution (c) continuing passivity for valve metals to very positive potentials. Pitting between critical pitting lim and inhibition potential fsj in the presence of aggressive anions and inhibitors.
It should be mentioned that passive layers are not protective in all environments. In the presence of so-called aggressive anions, passive layers may break down locally, which leads to the formation of corrosion pits. They grow with a high local dissolution current density into the metal substrate with a serious damage of the metal within very short time. In this sense halides and some pseudo halides like SCN are effective. Chloride is of particular interest due to its presence in many environments. Pitting corrosion starts usually above a critical potential, the so-called pitting potential /i]>j. In the presence of inhibitors an upper limit, the inhibition potential Ej is observed for some metals. Both critical potentials define the potential range in which passivity may break down due to localized corrosion as indicated in Fig. 1. [Pg.275]

PURPOSE AND RATIONALE Once a compound is identified in an efflux assays it is sometimes of importance to discriminate between efflux, inhibition potential and to determine the efflux transporter responsible for efflux of the compound. [Pg.451]

Identifying a drug as an inhibitor of a given P450 isoenzyme does not necessarily imply, that the drug will cause clinically relevant drag interactions. The inhibition potential must be considered in the following context (Madan 2002) ... [Pg.551]


See other pages where Inhibition potential is mentioned: [Pg.483]    [Pg.822]    [Pg.428]    [Pg.120]    [Pg.210]    [Pg.349]    [Pg.123]    [Pg.208]    [Pg.206]    [Pg.208]    [Pg.213]    [Pg.184]    [Pg.234]    [Pg.425]    [Pg.425]    [Pg.406]    [Pg.423]    [Pg.130]    [Pg.347]    [Pg.191]    [Pg.1314]    [Pg.1315]    [Pg.1890]    [Pg.65]    [Pg.209]    [Pg.121]    [Pg.283]    [Pg.10]    [Pg.272]    [Pg.369]    [Pg.554]    [Pg.202]    [Pg.71]    [Pg.1975]    [Pg.167]   
See also in sourсe #XX -- [ Pg.275 , Pg.369 ]




SEARCH



Does Mitochondrial Inhibition Mimic the Hypoxia-Induced Receptor Potential in Neonatal Chromaffin Cells

Membrane potential respiratory inhibition

Pitting corrosion inhibition potentials

Potential inhibition pathways

© 2024 chempedia.info