T cell repertoire

Pepin et al. (1992) generated transgenic mice in which antisense RNA complementary to GR cDNA led to reduced expression mostly in neuronal tissues. Consequently, this was found to result in an impaired behavior, a defective response to stress as well as in obesity. King et al. (1995) generated transgenic mice where reduced GR expression was limited to the thymus. This leads to an altered thymocyte development, changes in the T-cell repertoire, and a reduced risk to develop autoimmune diseases. 

McVay, L.D. et al. The generation of human gamma delta T cell repertoires during fetal development, J. Immunol., 160, 5851, 1998. 

Wooley, P.H. et al., Pristane-induced arthritis in mice. V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire. Arthritis Rheum., 41,2022, 1998. 

Von Boehmer H Selection of the T-cell repertoire receptor-controlled checkpoints in T-cell development. Adv Immunol 2004 84 201-238. 

Burchill MA, Yang J, Vang KB, Moon JJ, Chu HH, Lio CW, Vegoe AL, Hsieh CS, Jenkins MK, Farrar MA Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 2008 28 112-121. 

WoodfoUc JA. Sung SS. Benjamin DC. Lee JK. Platts-Mills TA Distinct human T cell repertoires mediate immediate and delayed-type hypersensitivity to the Trichophyton antigen. Tri r 2. J Immunol 2000 165 4379-4387. 

Fowell D, Mason D Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4 -I- T cell subset that inhibits this autoimmune potential. J Exp Med 1993 177 627-636. 

Although central tolerance is the major mechanism to establish the T-cell repertoire by positive and negative selection mechanisms, thymic deletion of harmful T-cell populations is incomplete. Therefore, the immune system has developed mechanisms that deal with tolerance in the peripheral lymphoid organs providing the necessary... 

McCue D, Ryan K, Wraith DC, Anderton SM Activation thresholds determine susceptibility to peptide-induced tolerance in a heterogeneous myelin-reactive T cells repertoire. J Neuroimmunol 2004 156 96-106. 

Figure 1. Shaping the T cell repertoire in hemopoetic stem cell transplantation and immnno-therapy of malignant disease by T cell antigen receptor transfer.

In conclusion, these results demonstrate that affinity and specificity of A2.1-restricted TCRs, selected in Tg mice by circumventing self-tolerance to universal hdm2- and wt p53-derived CTL epitopes, can be successfully delivered into human T lymphocytes. This, however, is precisely the molecular requirement to rescue the human T cell repertoire with high-affinity leukemia and tumor-reactive TCRs that have been lost due to the establishment of antigen-specific self-tolerance [13, 14]. 

HIV-specific CD8+ function may result from continued mutation and high levels of viral turnover, which gradually diminishes the capability of the cell to recognize the genetic sequences of the virus due to killing of some of the CD8 T cells repertoire by HIV itself. 

Rocha B, von Boehmer H Peripheral selection of the T cell repertoire. Science 1991 251 1225-1228. 

Tary-Lehmann, M., Lehmann, P. V., Schols, D., Roncarolo, M. G. and Saxon, A. (1994). Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras. J. Exp. Med. 180 1817-1827. 

The immune windows , along with developmental windows for the respiratory system, were identified at a workshop sponsored by the USEPA and the March of Dimes (see Dietert et al., 2000 Holladay Smialowicz, 2000 Landreth, 2002). They include 1) initiation of haematopoiesis, 2) migration and expansion of stem cell populations, 3) colonization events, including bone marrow colonization, pre-T cell seeding to the thymus, T cell education, T cell repertoire establishment, then seeding of the periphery by mature T cells, 4) acquisition of immunocompetence, and, finally, 5) the... 

Cairo C, Propp N, Hebbeler AM, et al. The Vgamma2/Vdelta2 T-cell repertoire in Macaca fascicularis functional responses to phosphoantigen stimulation by the Vgamma2/Jgammal.2 subset. Immunology 2005 115(2) 197-205. 

A schemadc view on the main processes that lead to autoimmune cendal demyelinadon is presented in Figures 18.2 and 18.3. Autoreaedve, myelin andgen-specific T cells are part of the normal T-cell repertoire, although at low frequency. These cells are thought to be acdvated in the peripheral immune system... 

Ria F, varr derr Elzerr P, Madakamutil LT, Miller JE, Maverakis E, Sercai z EE (2001) Molecular characterization of tire T cell repertoire using immurroscope analysis and its possible implementation in clinical practice. Cun Mol Med 1 297—304. 

Ureta-VidalA,Firat H, Perarnau B, Lemonnier FA (1999) Phenotypical and functional characterization of the CD8 T cell repertoire of HLA-A2.1 transgenic, H-2K null D nuU double knockout mice. J Immimol 163 2555-2560... 

Miller, S. D., McRae, B. L., Vanderlugt, C. L., et al., Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases, Immunol. Rev., 144, 225, 1995. 

The demonstration that SAgs encoded by endogenous murine retroviruses caused the deletion of CD4+CD8+ precursors in the thymus provided the first formal evidence for a negative selection of the T cell repertoire based on clonal deletion [16, 17]. It was subsequently shown that the bSAg SEB also caused deletion of CD4+CD8+ precursors in the thymus [18]. 

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